2009
Modeling premature brain injury and recovery
Scafidi J, Fagel DM, Ment LR, Vaccarino FM. Modeling premature brain injury and recovery. International Journal Of Developmental Neuroscience 2009, 27: 863-871. PMID: 19482072, PMCID: PMC2783901, DOI: 10.1016/j.ijdevneu.2009.05.009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBrain injuryAnimal modelsSignificant public health problemPremature brain injuryPublic health problemRelevant animal modelsNeurodevelopmental sequelaePreterm brainPreterm infantsPremature birthPreclinical modelsHealth problemsInjuryBrain structuresCellular mechanismsBrainInfantsSchool ageNeuroanatomical structuresVariable degreesRecent insightsEpigenetic mechanismsSequelaeTherapyRecovery
2004
Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex
Schwartz ML, Vaccarino F, Chacon M, Yan WL, Ment LR, Stewart WB. Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex. Seminars In Perinatology 2004, 28: 379-388. PMID: 15693394, DOI: 10.1053/j.semperi.2004.10.009.Peer-Reviewed Original ResearchConceptsDays of hypoxiaPreterm birth resultsNeuronal sizeBirth resultsHypoxic exposureCell numberChronic neonatal hypoxiaChronic sublethal hypoxiaNeonatal rodent modelPerinatal period altersRat cerebral cortexNeuronal cell numberBcl-2Glial cell numbersNormoxic environmentPostnatal day 3Cortical cell numberSignificant neurodevelopmental disabilitiesWestern blot analysisPreterm birthNeonatal hypoxiaNormoxic exposureCerebral cortexChronic hypoxiaControl pupsInjury and repair in developing brain
Vaccarino FM, Ment LR. Injury and repair in developing brain. Archives Of Disease In Childhood Fetal & Neonatal 2004, 89: f190. PMID: 15102716, PMCID: PMC1721670, DOI: 10.1136/adc.2003.043661.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements