2013
Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain
Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM. Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain. Journal Of Neuroscience 2013, 33: 10802-10814. PMID: 23804101, PMCID: PMC3693057, DOI: 10.1523/jneurosci.3621-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimetabolitesAxonsBrain ChemistryBromodeoxyuridineCell CountCerebral CortexCerebral VentriclesDensitometryDependovirusDNA, ComplementaryFemaleFibroblast Growth Factor 2Green Fluorescent ProteinsImmunohistochemistryIn Situ HybridizationLymphoid Enhancer-Binding Factor 1MiceNeocortexPregnancyReal-Time Polymerase Chain ReactionRNAWnt3A ProteinConceptsVentricular zoneIntermediate neuronal progenitorsSubventricular zoneCortical gyrificationCortical primordiumRegion-specific actionsFibroblast growth factor-2ER81 expressionGrowth factor 2Ventricular injectionCortical layer structureBasal radial gliaCortical gyriRadial gliaMouse brainCortical hemEmbryonic day 11.5Neuronal progenitorsGyrus formationLEF1 expressionGyrificationNeurogenesisLissencephalic speciesFactor 2Impaired growth
2011
FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis
Rash BG, Lim HD, Breunig JJ, Vaccarino FM. FGF Signaling Expands Embryonic Cortical Surface Area by Regulating Notch-Dependent Neurogenesis. Journal Of Neuroscience 2011, 31: 15604-15617. PMID: 22031906, PMCID: PMC3235689, DOI: 10.1523/jneurosci.4439-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnimalsBrainBromodeoxyuridineCaspase 3Cell CountCell DifferentiationCells, CulturedCerebral CortexDNA-Binding ProteinsElectroporationEmbryo, MammalianEye ProteinsFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsFibroblast Growth FactorsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsHomeodomain ProteinsKi-67 AntigenMiceMice, TransgenicMutationNerve Tissue ProteinsNeurogenesisNeuronsPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, Fibroblast Growth FactorReceptors, NotchRepressor ProteinsSignal TransductionStem CellsT-Box Domain ProteinsTranscription FactorsConceptsCortical neurogenesisCortical surface area expansionCortical surface expansionCortical surface areaGrowth factor receptorEmbryonic day 12.5Fibroblast growth factor receptorFGFR mutantsNormal miceCortical layer structureCortical developmentNeurogenic stagesDominant negative FGFRLoss of functionRadial progenitorsNeurogenesisNotch pathway genesSevere deficitsFactor receptorDay 12.5Notch pathwayMiceSimultaneous activationGreater proportionFGFR activity