2024
Estimating the economic impacts for caregivers of young people with mental health problems in a Brazilian cohort
Ziebold C, McDaid D, King D, Romeo R, Ribeiro W, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Evans-Lacko S. Estimating the economic impacts for caregivers of young people with mental health problems in a Brazilian cohort. Value In Health 2024 PMID: 39477147, DOI: 10.1016/j.jval.2024.10.3802.Peer-Reviewed Original ResearchCaregivers of young peopleMental health problemsHealth problemsService usePersonal mental health problemsYoung peopleCosts of productivity lossOut-of-pocket expensesMental health issuesHousehold tasksBrazilian cohortLogistic regression modelsCaregiver characteristicsHealthcare utilisationFemale caregiversSocioeconomic groupsCaregiversTargeted policy interventionsHealth issuesGeneralised linear modelsProductivity lossHigh impairmentAssess productivity lossRegression modelsEconomic impactAuthor Correction: Obsessive–compulsive disorder
Stein D, Costa D, Lochner C, Miguel E, Reddy Y, Shavitt R, van den Heuvel O, Simpson H. Author Correction: Obsessive–compulsive disorder. Nature Reviews Disease Primers 2024, 10: 79. PMID: 39414819, DOI: 10.1038/s41572-024-00569-z.Peer-Reviewed Original ResearchF18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING
Ito L, Ota V, Fernandes D, Martins A, Carvalho C, Zugman A, Sato J, Bressan R, Miguel E, Pan P, Salum G, Belangero S, Santoro M. F18. ROLE OF PSYCHIATRIC-ASSOCIATED SNVS IN THE EARLY ADULTHOOD: INSIGHTS FROM LONGITUDINAL NEUROIMAGING. European Neuropsychopharmacology 2024, 87: 214-215. DOI: 10.1016/j.euroneuro.2024.08.429.Peer-Reviewed Original ResearchPost-traumatic stress disorderAttention deficit/hyperactivity disorderBrain regionsBipolar disorderMental conditionBrain structuresBrazilian High-Risk Cohort StudyPrefrontal cortex regionsFrontal pole regionsHigh Risk Cohort StudyLateral orbitofrontal regionGenome-wide association studiesSignificant main effectDepressive disorderMixed-effects modelsStress disorderDeficit/hyperactivity disorderFrontal cortexOrbitofrontal regionsBiological underpinningsGenetic influencesCortex regionsLongitudinal relationshipIntracranial volumeEarly adulthoodAssociation Between Juvenile Psychotic Experiences and Problematic Gaming
Fernandes A, Biokino R, Miguel A, Machado V, Koga G, Fonseca L, Pan P, Roza T, Salum G, Passos I, Rohde L, Miguel E, Ziebold C, Gadelha A. Association Between Juvenile Psychotic Experiences and Problematic Gaming. Schizophrenia Bulletin Open 2024, 5: sgae021. PMID: 39296676, PMCID: PMC11408271, DOI: 10.1093/schizbullopen/sgae021.Peer-Reviewed Original ResearchPsychotic experiencesProblematic gamingGame addictionDSM-IVBrazilian community sampleDSM-IV diagnosisMental health conditionsCommunity samplePsychiatric disordersCross-sectional subsamplePsychiatric conditionsAssociated with significant adverse outcomesReport PEBehavioral pathwaysLevels of PESignificant adverse outcomesAssociated with PEPE scoresSociodemographic variablesAdverse outcomesBrazilian cohortDisordersParticipantsHealth conditionsLinear regression analysisAssociations between a Brazilian suicide awareness campaign and suicide trends from 2000 to 2019: Joinpoint and regression discontinuity analysis
Damiano R, Beiram L, Damiano B, Hoffmann M, Moreira-Almeida A, Rück C, Tavares H, Brunoni A, Miguel E, Menezes P, Salum G. Associations between a Brazilian suicide awareness campaign and suicide trends from 2000 to 2019: Joinpoint and regression discontinuity analysis. Journal Of Affective Disorders 2024, 365: 459-465. PMID: 39187205, DOI: 10.1016/j.jad.2024.08.134.Peer-Reviewed Original ResearchJoinpoint analysisRegression discontinuity analysisAwareness campaignsLow-and-middle-income countriesSuicide trendsNational awareness campaignDiscontinuity analysisOfficial notification systemRates of suicidePublic awareness campaignsReduction interventionsGlobal health concernPotential unintended effectsCausative implicationAssess trendsEconomic factorsHealth concernEuripedes C. Miguel: Risk factors for obsessive-compulsive and other mental health disorders and their treatment and public policy implications
Miguel E. Euripedes C. Miguel: Risk factors for obsessive-compulsive and other mental health disorders and their treatment and public policy implications. 2024, 1-4. DOI: 10.61373/bm024k.0061.Peer-Reviewed Original ResearchMental health disordersHealth disordersMental health educationDepartment of PsychiatryInstitute of PsychiatryHealth educationMental healthFaculty of MedicineGeneral HospitalMedical schoolsMassachusetts General HospitalObsessive-compulsivePsychiatry residentsHarvard Medical SchoolDisorders programRisk factorsHead of the Department of PsychiatryEarly identificationPsychiatryUniversity of Sao PauloSao PauloPostdoctoral fellowshipAdjunct Associate ProfessorProfessional achievementsLife journeyMaternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach
Euclydes V, Braga C, Gouveia G, Martinez R, Camilo C, Simões S, Martins-Jr D, Fracolli L, Argeu A, Ferraro A, Matijasevich A, Fatori D, Miguel E, Polanczyk G, Brentani H. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. Brain Behavior & Immunity - Health 2024, 40: 100832. PMID: 39193418, PMCID: PMC11347843, DOI: 10.1016/j.bbih.2024.100832.Peer-Reviewed Original ResearchMaternal immune responseTrimester of pregnancyImmune responseNeurodevelopmental outcomesImmunological markersImmunological biomarkersMaternal childhood traumaNeurodevelopmental trajectoriesMother's immune responseEarly stages of pregnancyWeeks of pregnancyMaternal psychosocial stressStages of pregnancyStages of gestationRandomized clinical trialsAnti-inflammatory stateMaternal stress experienceNeurodevelopmental scoresImmune system responseInflammatory biomarkersClinical trialsPregnancyPsychosocial stress conditionBlood samplesLinear mixed-effects modelsThe trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores
Salto A, Salum G, Hoffmann M, Santoro M, Zugman A, Pan P, Belangero S, Ito L, Doretto V, Croci M, Brañas M, de Giusti C, Da Silva‐Jr F, Ribeiro S, Miguel E, Leckman J. The trajectory of anxiety symptoms during the transition from childhood to young adulthood is predicted by IQ and sex, but not polygenic risk scores. JCPP Advances 2024 DOI: 10.1002/jcv2.12268.Peer-Reviewed Original ResearchAnxiety symptomsIntelligence quotientTrajectory class membershipPolygenic risk scoresTrajectory classesLate adolescenceCourse of anxiety symptomsScreen for Child Anxiety Related DisordersTrajectories of anxiety symptomsBrazilian High-Risk CohortYoung adulthoodEffect of intelligence quotientAnxiety related disordersHigh-decreasing classClass membershipLongitudinal studyConfirmatory factor analysisGrowth mixture modelingIncidence of anxiety symptomsInternalizing symptomatologyLow-increasing classHigher IQCognitive abilitiesAnxiety riskFactor analysisGPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorderIs waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive disorderCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual-patient data meta-analysisPosttreatment scoresEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusIndividual participant data meta-analysisSystematic reviewDisordersData meta-analysisPosttreatmentRemission definitionsImpressive improvementCausal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study
Blumrich L, Silva L, Barreto V, Rohde L, Polanczyk G, Miguel E, Grisi S, Fleitlich-Bilyk B, Ferraro A. Causal Pathways Between the Acute Experience of Violence During Pregnancy and Fetal Intrauterine Growth Restriction: A Cohort Study. Journal Of Women's Health 2024, 33: 765-773. PMID: 38551182, DOI: 10.1089/jwh.2023.0645.Peer-Reviewed Original ResearchIntrauterine growth restrictionAssociated with intrauterine growth restrictionGrowth restrictionProspective population-based birth cohortCausal pathwaysFetal intrauterine growth restrictionPopulation-based birth cohortExperiences of violenceNegative health consequencesAcute experimentsHealth consequences of violenceEmergency careGestational depressionGestational trimesterLow birthweightBirth cohortAlcohol consumptionCohort studyBlood pressurePregnancyConsequences of violencePath analysis modelMediation analysisCohortAdequate fitIncreases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyriPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 33: 3571-3581. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal educationPost-COVID-19 condition: systemic inflammation and low functional exercise capacity
de Castro G, Gama L, Ramos A, da Silva G, de Souza Teixeira A, Cunha-Neto E, de Souza H, Marie S, Talib L, Coelho V, Kalil J, de Araujo A, Ritto A, Belon A, Santos A, Barrére A, Sawamura M, Lamas C, Baldi B, Carvalho C, Kulikowski L, Damiano R, Imamura M, Neto J, Lira F, Otoch J, Miguel E, Battistella L, Forlenza O, Busatto G, Seelaender M. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity. Frontiers In Nutrition 2024, 11: 1295026. PMID: 38549752, PMCID: PMC10973152, DOI: 10.3389/fnut.2024.1295026.Peer-Reviewed Original ResearchPost-COVID-19 conditionTimed Up and Go testUp-and-go testPhysical performance testsAcute COVID-19Low handgrip strengthFollow-up assessment 6Cross-sectional studySelf-reported symptomsFollow-up assessmentQuality of lifeDiagnosing pulmonary lesionsHandgrip strengthSerum cytokine profilesSerum cytokine levelsImpact of inflammationControl groupMCP-1 levelsIL-4 concentrationMale participantsHospital dischargeSymptom questionnaireSymptom groupsFemale participantsDebilitating symptomsFacing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic
Guimarães-Fernandes F, Benoit L, de Oliveira L, Neto P, Feniman D, Correia A, de Oliveira Bosoni N, Macaya D, Miguel E, Ceron-Litvoc D, Castellana G. Facing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic. Psychopathology 2024, 57: 169-181. PMID: 38467115, DOI: 10.1159/000536135.Peer-Reviewed Original ResearchMedical residentsHealthcare professionalsExperiences of medical residentsCOVID-19 pandemicHealth care providersHealthcare delivery challengesLived experienceSemi-structured interviewsFear of infectionCare providersLimit situationPsychiatric careExistential defensivenessContent themesCOVID-19Social isolationEmotional overloadHealthcarePhenomenological analysisInductive analysisPublic healthPatient deathProfessional approachResidentsOvercome adversityAge of onset of obsessive-compulsive disorder differentially affects white matter microstructure
Vriend C, de Joode N, Pouwels P, Liu F, Otaduy M, Pastorello B, Robertson F, Ipser J, Lee S, Hezel D, van Meter P, Batistuzzo M, Hoexter M, Sheshachala K, Narayanaswamy J, Venkatasubramanian G, Lochner C, Miguel E, Reddy Y, Shavitt R, Stein D, Wall M, Simpson H, van den Heuvel O. Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure. Molecular Psychiatry 2024, 29: 1033-1045. PMID: 38228890, PMCID: PMC11176057, DOI: 10.1038/s41380-023-02390-8.Peer-Reviewed Original ResearchObsessive-compulsive disorderPathophysiology of obsessive-compulsive disorderObsessive-compulsive disorder groupAge of OCD onsetOCD onsetHealthy controlsMedication-free adultsWhite matter microstructural alterationsVisual attention processesWhite matter microstructureStructural brain networksStructural connectome analysisWhite matter tractsBayesian multilevel analysisDirection of effectAttentional processesOCD individualsBrain signaturesBrain networksDiffusion MRI studiesPost hoc analysisSagittal stratumConnectome analysisMultilevel analysisStructural connectomeItem-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace.
Petrilli-Mazon V, Carvalho-Alves M, Miguel E, Corchs F, Curi M, Wang Y. Item-wise validity study of the Impact of Event Scale - Revised (IES-R): self-reported reactions of hospital personnel exposed to a stressful workplace. Brazilian Journal Of Psychiatry 2024 PMID: 39602572, DOI: 10.47626/1516-4446-2024-3882.Peer-Reviewed Original ResearchIES-RItem response theoryTraumatic experiencesAssociated with traumatic experiencesItem analysisPresentation of PTSDTrauma-related distressMental disorder ratesSelf-reported reactionsPTSD measuresTrauma symptomsTraumatic exposureTraumatic symptomsTraumatic distressItem poolDistress severityDisorder ratesPTSDSleep disturbanceEffective scaleResponse theoryDistressItem parametersItemsHeterogeneous prevalenceTrajectories of anxiety, depression, and posttraumatic stress among healthcare workers during the COVID-19 pandemic: one-year monthly follow-up.
Carvalho-Alves M, Petrilli-Mazon V, Zuccolo P, Fatori D, Rocha F, Brunoni A, Polanczyk G, Miguel E, Wang Y, Corchs F. Trajectories of anxiety, depression, and posttraumatic stress among healthcare workers during the COVID-19 pandemic: one-year monthly follow-up. Brazilian Journal Of Psychiatry 2024 PMID: 39306862, DOI: 10.47626/1516-4446-2024-3720.Peer-Reviewed Original ResearchPosttraumatic stress symptomsFear of COVID-19Posttraumatic stressStress symptomsPredictor analysisTrajectories of anxietySelf-report scalesMental health outcomesPatterns of anxietyCOVID-19-related eventsEnhanced attentionEmotional distressAnxietyDepressionHealth outcomesLinear mixed modelsHealthcare workersHospital workforceHealth challengesPersonal health challengesInstitutional supportMonths follow-upCOVID-19Reduced riskLongitudinal patternsChapter 21 Gamma Knife for psychiatric indications
Lopes A, de Arruda I, Batistuzzo M, Gorgulho A, de Salles A, Miguel E. Chapter 21 Gamma Knife for psychiatric indications. 2024, 495-517. DOI: 10.1016/b978-0-443-18496-3.00021-5.Peer-Reviewed Original ResearchAnorexia nervosaObsessive-compulsive disorder patientsTreatment of psychiatric disordersAnterior limb of internal capsuleObsessive-compulsive disorderVentral anterior limbGamma KnifeGK radiosurgeryMajor depressionDisorder patientsPsychiatric disordersPsychiatric indicationsNervosaDepressionInternal capsuleSurgical modalitiesAdverse eventsDisordersAnorexiaRadiosurgeryWeight gainManiaPsychiatryBrain cystsComplications