2020
Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative
Simpson H, van den Heuvel O, Miguel E, Reddy Y, Stein D, Lewis-Fernández R, Shavitt R, Lochner C, Pouwels P, Narayanawamy J, Venkatasubramanian G, Hezel D, Vriend C, Batistuzzo M, Hoexter M, de Joode N, Costa D, de Mathis M, Sheshachala K, Narayan M, van Balkom A, Batelaan N, Venkataram S, Cherian A, Marincowitz C, Pannekoek N, Stovezky Y, Mare K, Liu F, Otaduy M, Pastorello B, Rao R, Katechis M, Van Meter P, Wall M. Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative. BMC Psychiatry 2020, 20: 68. PMID: 32059696, PMCID: PMC7023814, DOI: 10.1186/s12888-020-2439-2.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCircuit abnormalitiesNew global initiativesBrain signaturesGlobal InitiativeHealthy control subjectsMedication-free adultsMultiple brain circuitsMedication-free subjectsBackgroundObsessive–compulsive disorderClinical profileClinical symptomsControl subjectsClinical evaluationHealthy controlsLeading causeGlobal disabilityLifetime prevalenceResonance imagingNeurocognitive assessmentBrain circuitsImaging signaturesFunctional connectivityBrain-behavior associationsDisease dimensions
2018
Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder
Chacon P, Bernardes E, Faggian L, Batistuzzo M, Moriyama T, Miguel E, Polanczyk G. Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2018, 40: 388-393. PMID: 29898190, PMCID: PMC6899383, DOI: 10.1590/1516-4446-2017-2321.Peer-Reviewed Original ResearchConceptsPresence of OCSObsessive-compulsive disorderFirst-degree relativesObsessive-compulsive symptomsSocioeconomic statusImportant risk factorLow socioeconomic statusFuture longitudinal studiesClinical correlatesAssessed childrenRisk factorsDegree relativesFamily historySymptomsContamination/Longitudinal studyOCD diagnosisDisordersChildrenHigh rateFamily membersChildhoodCorrelatesStatus
2007
Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder
Chacon P, Rosario‐Campos M, Pauls D, Hounie A, Curi M, Akkerman F, Shimabokuro F, de Mathis M, Lopes A, Hasler G, Miguel E. Obsessive–compulsive symptoms in sibling pairs concordant for obsessive–compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2007, 144B: 551-555. PMID: 17440931, DOI: 10.1002/ajmg.b.30457.Peer-Reviewed Original Research