2023
Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil
Hoffmann M, Pine D, Georgiades K, Szatmari P, Miguel E, Pan P, Gadelha A, Rohde L, Merikangas K, Milham M, Satterthwaite T, Salum G. Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil. The Lancet Global Health 2023, 12: e79-e89. PMID: 37980914, PMCID: PMC10716620, DOI: 10.1016/s2214-109x(23)00462-x.Peer-Reviewed Original ResearchAlterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5p
2022
Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCerebellumChildCohort StudiesCross-Sectional StudiesExecutive FunctionHumansMental DisordersConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceChildhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, de Jesus Mari J, Gadelha A. Childhood individual and family modifiable risk factors for criminal conviction: a 7-year cohort study from Brazil. Scientific Reports 2022, 12: 13381. PMID: 35927553, PMCID: PMC9352677, DOI: 10.1038/s41598-022-13975-8.Peer-Reviewed Original ResearchConceptsCriminal convictionsImportance of povertyPublic problemsPopulation attributable risk fractionBrazilian youthGreat social impactYoung peopleModifiable risk factorsPovertySocial impactCrimeConvictionRisk factorsSubsequent criminal convictionsEradication interventionsChildren's exposureMiddle-income countriesFamily exposureYouthMultiple modifiable risk factorsOnly modifiable risk factorAttributable risk fractionSignificant risk factorsMajor public problemCohort studyAssociation between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study
Damiano R, Neto D, Oliveira J, Magalhães Santos J, Alves J, Guedes B, Nitrini R, de Araújo A, Oliveira M, Brunoni A, Voegels R, Bento R, Busatto G, Miguel E, Forlenza O, de Rezende Pinna F. Association between chemosensory impairment with neuropsychiatric morbidity in post-acute COVID-19 syndrome: results from a multidisciplinary cohort study. European Archives Of Psychiatry And Clinical Neuroscience 2022, 273: 325-333. PMID: 35633395, PMCID: PMC9142732, DOI: 10.1007/s00406-022-01427-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesCOVID-19HumansMorbidityOlfaction DisordersPost-Acute COVID-19 SyndromeSARS-CoV-2SmellTaste DisordersConceptsCohort studyChemosensory impairmentPost-acute COVID-19 syndromeCOVID-19 syndromeCentral nervous systemCOVID-19SARS-CoV-2Word list memory taskEpisodic memory impairmentSmell functionAdult patientsChemosensory dysfunctionAcute phaseNeuropsychiatric symptomsNeuropsychiatric morbidityGustatory lossHospitalization dataNeuropsychiatric impairmentEligible individualsSevere formCognition dysfunctionNervous systemMemory impairmentMultivariate analysisNeuropsychiatric disordersPost-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study
Damiano R, Caruso M, Cincoto A, de Almeida Rocca C, de Pádua Serafim A, Bacchi P, Guedes B, Brunoni A, Pan P, Nitrini R, Beach S, Fricchione G, Busatto G, Miguel E, Forlenza O, Group H. Post-COVID-19 psychiatric and cognitive morbidity: Preliminary findings from a Brazilian cohort study. General Hospital Psychiatry 2022, 75: 38-45. PMID: 35134702, PMCID: PMC8734055, DOI: 10.1016/j.genhosppsych.2022.01.002.Peer-Reviewed Original ResearchConceptsCognitive morbidityCognitive outcomesAnxiety disordersPost-traumatic stress disorderRelevant psychosocial variablesCognitive batteryMemory declineStructured psychiatric interviewStress disorderPsychosocial variablesStandardized measuresPsychosocial stressorsPsychometric testsCognitive impairmentPsychiatric interviewSevere formPreliminary findingsSARS-CoV-2 infectionCohort of survivorsLong-term outcomesAcute-phase diseaseBrazilian cohort studyCOVID-19DisordersDepression
2021
Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study
Ziebold C, Evans-Lacko S, Andrade M, Hoffmann M, Fonseca L, Barbosa M, Pan P, Miguel E, Bressan R, Rohde L, Salum G, Schafer J, de Jesus Mari J, Gadelha A. Childhood poverty and mental health disorders in early adulthood: evidence from a Brazilian cohort study. European Child & Adolescent Psychiatry 2021, 32: 903-914. PMID: 34853911, DOI: 10.1007/s00787-021-01923-2.Peer-Reviewed Original ResearchConceptsMental health disordersStressful life eventsEarly adulthoodHealth disordersPreventable risk factorsDifferent stressful life eventsInternalizing disordersBrazilian cohort studyProspective community cohortWell-Being AssessmentCohort studyCommunity cohortRisk factorsStratified analysisPsychiatric diagnosisExternalizing disordersChildhood povertyDisordersBaselineAdulthoodStandardized classificationHigh exposureLife eventsAssociationYoung people
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosisGene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents
Ota V, Santoro M, Spindola L, Pan P, Simabucuro A, Xavier G, Vieira-Fonseca T, Zanardo E, dos Santos F, Schäfer J, Kulikowski L, Galante P, Asprino P, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Gadelha A, Mari J, Bressan R, Salum G, Belangero S. Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents. Translational Psychiatry 2020, 10: 99. PMID: 32184383, PMCID: PMC7078305, DOI: 10.1038/s41398-020-0772-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrazilChildCohort StudiesGene ExpressionHumansMental DisordersPsychopathologyConceptsPsychiatric symptomsMental disordersChild Behavior Checklist total scoresTrajectories of psychopathologyBlood gene expression profilesHigh Risk Cohort StudyGeneral psychiatric symptomsBlood gene expression patternsPsychopathological trajectoriesCohort studyLow-low groupLongitudinal cohortPostmortem brainsGeneral psychopathologySpecific disordersTotal scoreGene expressionCBCL scoresGene expression changesGene expression profilesDisordersSymptomsRisk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort
Macul Ferreira de Barros P, do Rosário MC, Szejko N, Polga N, Requena GL, Ravagnani B, Fatori D, Batistuzzo MC, Hoexter MQ, Rohde LA, Polanczyk GV, Leckman JF, Miguel EC, de Alvarenga PG. Risk factors for obsessive–compulsive symptoms. Follow-up of a community-based youth cohort. European Child & Adolescent Psychiatry 2020, 30: 89-104. PMID: 32076869, DOI: 10.1007/s00787-020-01495-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsRisk factorsAbsence of breastfeedingOCS scoresBaseline anxiety disordersPotential risk factorsLarge community cohortLow socioeconomic statusRegression analysisMental health assessmentMaternal stress levelsLower intelligence quotientCommunity cohortChildhood adversityLower ageHigher OCS scoresAnxiety disordersPsychopathological factorsSocioeconomic statusGenetic factorsSignificant predictorsBaselineHealth assessmentScoresAge
2019
Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis
Caye A, Petresco S, de Barros A, Bressan R, Gadelha A, Gonçalves H, Manfro A, Matijasevich A, Menezes A, Miguel E, Munhoz T, Pan P, Salum G, Santos I, Kieling C, Rohde L. Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 990-997. PMID: 31442562, DOI: 10.1016/j.jaac.2019.07.939.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrazilChildChild, PreschoolCohort StudiesHumansRiskConceptsYounger ageADHD diagnosisMeta-AnalysisADHD symptomsPelotas cohortCommunity-based cohortPopulation-based cohortAttention-deficit/hyperactivity disorderHigh-risk studiesRelative young ageAttention-deficit/hyperactivity disorder (ADHD) symptomsWeb of ScienceHyperactivity disorder symptomsEpidemiology guidelinesEligible recordsRelative riskObservational studyHigh riskPsychiatric disordersEpidemiological cohortCohortSymptomsDiagnosisEffect estimatesHyperactivity disorderUse of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil
Fatori D, Salum G, Rohde L, Pan P, Bressan R, Evans-Lacko S, Polanczyk G, Miguel E, Graeff-Martins A. Use of Mental Health Services by Children With Mental Disorders in Two Major Cities in Brazil. Psychiatric Services 2019, 70: 337-341. PMID: 30651056, DOI: 10.1176/appi.ps.201800389.Peer-Reviewed Original ResearchConceptsMental health servicesMental disordersUnmet needHealth servicesHigh Risk Cohort StudyCombination of psychotherapyMental health treatmentChildren ages 6Cohort studyHealth treatmentCommunity studyAge 6DisordersHealth careLifetime useWhite childrenChildrenHigh rateTreatmentCurrent studyPorto AlegreSao PauloMedicationsPsychotherapyDiagnosis
2018
Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Bressan R, Jackowski A. Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems. European Child & Adolescent Psychiatry 2018, 28: 835-845. PMID: 30392120, DOI: 10.1007/s00787-018-1240-y.Peer-Reviewed Original ResearchConceptsFamily environmentMental health outcomesFamily coherenceEmotional problemsOrbitofrontal cortexTemporal poleResting-state fMRI dataLeft temporal poleSpontaneous brain oscillationsChild's family environmentRight orbitofrontal cortexOscillatory neural activityHealth outcomesBrain oscillationsBehavioral problemsNeural activityFMRI dataFMRI metricsBrain areasLow-frequency fluctuationsFractional amplitudeLower incidenceSpontaneous activityHigh incidenceExploratory studyThe economic impact of subthreshold and clinical childhood mental disorders
Fatori D, Salum G, Itria A, Pan P, Alvarenga P, Rohde L, Bressan R, Gadelha A, de Jesus Mari J, do Rosário M, Manfro G, Polanczyk G, Miguel E, Graeff-Martins A. The economic impact of subthreshold and clinical childhood mental disorders. Journal Of Mental Health 2018, 27: 588-594. PMID: 29708045, DOI: 10.1080/09638237.2018.1466041.Peer-Reviewed Original ResearchConceptsSubthreshold mental disordersClinical mental disordersMental disordersHigh Risk Cohort StudyCommon health problemLifetime cost estimatesChild mental disordersChildhood mental disordersWell-Being AssessmentSocial service useCohort studyYear old childrenService useEconomic burdenCost-effective programsHealth problemsBrazilian childrenCommunity studyMental healthOlder childrenDisordersDisorder assessmentSerious impairmentMajor Brazilian citiesChildren
2017
Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence
de Araujo C, Zugman A, Swardfager W, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, de Moura L, Del Aquilla M, Picon F, Amaro E, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. Journal Of Psychiatric Research 2017, 98: 51-58. PMID: 29288952, DOI: 10.1016/j.jpsychires.2017.12.008.Peer-Reviewed Original ResearchConceptsPsychiatric disordersVal66Met polymorphismCortical thicknessBrain-derived neurotrophic factor (BDNF) Val66Met polymorphismRegional structural brain changesNeurotrophic factor Val66Met polymorphismPrefrontal cortexStructural brain changesLateral temporal cortexEffect of Val66MetBilateral prefrontal cortexVal66Met effectsWindow of vulnerabilityCortical maturationBrain changesOccipital lobeMet carriersAtypical neurodevelopmentMRI scansPsychiatric diagnosisTemporal cortexDiagnosis interactionVal66MetNeuropsychiatric disordersBrain morphologyLow frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample
Hoexter M, Biazoli C, Alvarenga P, Batistuzzo M, Salum G, Gadelha A, Pan P, Anés M, Mancini-Martins L, Moura L, Soriano-Mas C, Aquilla M, Amaro E, Rohde L, Jackowski A, Bressan R, Miguel E, do Rosario M, Sato J. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample. Journal Of Psychiatric Research 2017, 96: 224-230. PMID: 29102817, DOI: 10.1016/j.jpsychires.2017.10.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsBrain spontaneous activityLow-frequency fluctuationsSpontaneous activityRight sensorimotor cortexHigh Risk Cohort StudyState functional magnetic resonance imaging (rs-fMRI) dataSpontaneous activity changesPredictors of riskWell-Being AssessmentSpontaneous brain activitySuperior temporal cortexSuperior temporal gyrusCohort studyObsessive-compulsive disorderSensorimotor cortexMagnetic resonance imaging dataPsychiatric disordersOverall psychopathologyTemporal gyrusFractional amplitudeGeneral linear modelFunctional magnetic resonance imaging (fMRI) dataCompulsive symptomsBrain activityVentral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture riskPrevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study
Simioni A, Pan P, Gadelha A, Manfro G, Mari J, Miguel E, Rohde L, Salum G. Prevalence, clinical correlates and maternal psychopathology of deliberate self-harm in children and early adolescents: results from a large community study. Brazilian Journal Of Psychiatry 2017, 40: 48-55. PMID: 28832748, PMCID: PMC6899416, DOI: 10.1590/1516-4446-2016-2124.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderOppositional defiant disorderMaternal psychopathologyPsychiatric disordersClinical diagnosisCo-occurring psychiatric disordersAnxiety disordersHigh Risk Cohort StudyCommunity-based studyDiagnosis of depressionMaternal mood disordersMaternal anxiety disordersPotential confounding factorsLarge community studyChildhood psychiatric disordersChild's clinical diagnosisPrevalence of DSHCohort studyMiddle-income countriesClinical correlatesMood disordersPrevalence estimatesConfounding factorsAge groupsLogistic regressionComparability of an ADHD Latent Trait Between Groups: Disentangling True Between-Group Differences From Measurement Problems
Cogo-Moreira H, Lúcio P, Swardfager W, Gadelha A, de Jesus Mari J, Miguel E, Rohde L, Salum G. Comparability of an ADHD Latent Trait Between Groups: Disentangling True Between-Group Differences From Measurement Problems. Journal Of Attention Disorders 2017, 23: 712-720. PMID: 28478691, DOI: 10.1177/1087054717707047.Peer-Reviewed Original ResearchGene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spindola L, Pan P, Moretti P, Ota V, Santoro M, Cogo-Moreira H, Gadelha A, Salum G, Manfro G, Mari J, Brentani H, Grassi-Oliveira R, Brietzke E, Miguel E, Rohde L, Sato J, Bressan R, Belangero S. Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder. Journal Of Psychiatric Research 2017, 92: 24-30. PMID: 28384542, DOI: 10.1016/j.jpsychires.2017.03.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild AbuseCohort StudiesDepressive Disorder, MajorFemaleGene ExpressionGenetic TestingHumansHypothalamo-Hypophyseal SystemInterleukin-1betaMaleModels, BiologicalPeptide FragmentsPituitary-Adrenal SystemReceptors, GlucocorticoidReceptors, Tumor Necrosis Factor, Type IResidence CharacteristicsRNA, MessengerTumor Necrosis Factor-alphaConceptsMajor depressive disorderBlood of childrenDepressive disorderChildhood maltreatmentMDD diagnosisRole of glucocorticoidsWhole blood mRNA levelsCM historyGene expressionAdrenal axisIllness exposureHealthy controlsDepressive symptomsMDD groupLarger studyMRNA expressionMRNA levelsExpression levelsInflammationTNFChildrenDiagnosisBloodAdolescentsNR3C1