2024
Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample
Bado P, Salum G, Rohde L, Gadelha A, Pan P, Miguel E, Tripp G, Furukawa E. Is waiting for rewards good for you? No association between impulsive choice, psychopathology, and functional outcomes in a large cohort sample. JCPP Advances 2024, 4: e12231. PMID: 38827985, PMCID: PMC11143955, DOI: 10.1002/jcv2.12231.Peer-Reviewed Original ResearchDelayed rewardsPsychiatric conditionsPresence of psychiatric disordersLife outcomesBaseline task performanceImpulsive choicePositive long-term outcomesImmediate rewardsPsychiatric disordersTask performanceADHDResults ChildrenRewardChildren's preferencesStronger preferenceSchool-based cohortDisordersLongitudinal outcomesCohort sampleFunctional outcomesChildrenCohort of Brazilian childrenBrazilian childrenPsychopathologyDiverse populationsPerinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology
Leusin F, Damiano R, Mendes L, Hoffmann M, Manfro A, Pan P, Gadelha A, de Jesus Mari J, Manfro G, Miguel E, Rohde L, Bressan R, Salum G. Perinatal and neonatal factors and mental disorders in children and adolescents: looking for the contributions of the early environment to common and dissociable aspects of psychopathology. European Child & Adolescent Psychiatry 2024, 33: 3571-3581. PMID: 38519607, DOI: 10.1007/s00787-024-02402-0.Peer-Reviewed Original ResearchMental disordersPsychiatric disordersCo-occurrence of mental disordersPresence of mental disordersDomains of psychopathologyYears of age childrenModel psychiatric disordersPsychiatric disorder diagnosisOverall psychopathologyBifactor modelDisorder diagnosisPsychopathologyBehavioral assessmentP-factorEarly environmentLow level of maternal educationLevel of maternal educationLow socioeconomic statusDisordersNeonatal factorsPrimary caregiversAge childrenAssociated with male sexSocioeconomic statusMaternal education
2022
Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes
Borges M, Hoffmann M, Simioni A, Axelrud L, Teixeira D, Zugman A, Jackowski A, Pan P, Bressan R, Parker N, Germann J, Bado P, Satterthwaite T, Milham M, Chakravarty M, Rohde L, Miguel E, Paus T, Salum G. Deviations from a typical development of the cerebellum in youth are associated with psychopathology, executive functions and educational outcomes. Psychological Medicine 2022, 53: 5698-5708. PMID: 36226568, DOI: 10.1017/s0033291722002926.Peer-Reviewed Original ResearchConceptsExecutive functionTypical developmentInhibitory controlAcademic achievementCerebellar volumeHigher executive functionChild Behavior ChecklistTypical brain developmentSchool achievementBehavior ChecklistMental health conditionsStandardized measuresMediation analysisMental healthHigh Risk Cohort StudyEducational outcomesPsychopathologyBrain developmentMental conditionLongitudinal analysisYouthSpecific factorsAchievementCognitionAdolescenceDisentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersThreat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents
Schäfer J, McLaughlin K, Manfro G, Pan P, Rohde L, Miguel E, Simioni A, Hoffmann M, Salum G. Threat and deprivation are associated with distinct aspects of cognition, emotional processing, and psychopathology in children and adolescents. Developmental Science 2022, 26: e13267. PMID: 35417607, PMCID: PMC10028496, DOI: 10.1111/desc.13267.Peer-Reviewed Original ResearchConceptsChild Behavior ChecklistExecutive functionEmotional processingChildhood adversityBrazilian High-Risk CohortForms of adversityPoor developmental outcomesAttention biasAngry facesCognitive tasksCognitive developmentDevelopmental correlatesBehavior ChecklistChild developmentDevelopmental outcomesLongitudinal associationsGeneral psychopathologyPsychopathologyAdversityLatent constructsDifferential associationsWorse performanceDistinct aspectsCognitionMeaningful influence
2019
Differences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population
Moriyama T, van Os J, Gadelha A, Pan P, Salum G, Manfro G, de Jesus Mari J, Miguel E, Rohde L, Polanczyk G, McGuire P, Bressan R, Drukker M. Differences Between Self-Reported Psychotic Experiences, Clinically Relevant Psychotic Experiences, and Attenuated Psychotic Symptoms in the General Population. Frontiers In Psychiatry 2019, 10: 782. PMID: 31736802, PMCID: PMC6829673, DOI: 10.3389/fpsyt.2019.00782.Peer-Reviewed Original ResearchSelf-reported psychotic experiencesPsychotic symptomsPsychotic experiencesAffective flatteningHigh Risk Cohort StudyAttenuated Psychotic SymptomsChild mental healthCohort studyStrength of associationFemale sexClinical assessmentLevels of psychopathologyGeneral populationPsychiatric disordersClinical relevanceEarly interventionMental healthIndependent interviewerMost associationsParent informationSymptomsAssociationPresent studyPsychopathologyPsychologists' assessmentEffects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders
Carvalho C, Pan P, Ota V, Spindola L, Xavier G, Santoro M, Mazzotti D, Pellegrino R, Hakonarson H, Rohde L, Miguel E, Gadelha A, Bressan R, Belangero S. Effects of the interaction between genetic factors and maltreatment on child and adolescent psychiatric disorders. Psychiatry Research 2019, 273: 575-577. PMID: 30716596, DOI: 10.1016/j.psychres.2019.01.078.Peer-Reviewed Original ResearchConceptsMental disordersSingle nucleotide polymorphismsSchool-based prospective studyAdolescent psychiatric disordersBonferroni multiple comparison correctionChild maltreatmentProspective studyPsychiatric disordersMultiple comparison correctionSignificant associationGenetic factorsDisordersNucleotide polymorphismsPsychopathologyLogistic modelMaltreatment
2017
Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Jackowski A, Bressan R. Association between abnormal brain functional connectivity in children and psychopathology: A study based on graph theory and machine learning. The World Journal Of Biological Psychiatry 2017, 19: 119-129. PMID: 28635541, DOI: 10.1080/15622975.2016.1274050.Peer-Reviewed Original ResearchConceptsBilateral posterior temporal corticesAbnormal brain functional connectivityMental health disordersBilateral posterior cingulateBrain networksBrain functional connectivityResting-state fMRI dataPosterior temporal cortexBrain network organizationLevels of psychopathologyTemporal cortexHealth disordersTemporal polePosterior cingulateMental disordersBrain developmentFunctional connectivityBrain connectivitySignificant decreaseDisordersGraph theory measuresIndividual brain networksBiological measuresPsychopathologySubjectsA General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function
Martel M, Pan P, Hoffmann M, Gadelha A, do Rosário M, Mari J, Manfro G, Miguel E, Paus T, Bressan R, Rohde L, Salum G. A General Psychopathology Factor (P Factor) in Children: Structural Model Analysis and External Validation Through Familial Risk and Child Global Executive Function. Journal Of Psychopathology And Clinical Science 2017, 126: 137-148. PMID: 27748619, DOI: 10.1037/abn0000205.Peer-Reviewed Original ResearchConceptsChildren's executive functionExecutive functionGlobal executive functionGeneral p factorLittle residual varianceConfirmatory factor analysisChildren ages 6Specific factorsGeneral psychopathology factorFamily riskChild psychopathologyCommunity sampleDisorder diagnostic criteriaMental health researchParental factorsGeneral psychopathologyBest fitting modelPsychopathologyPsychopathology factorAge 6P-factorExternal validityFactor analysisStructured interviewsMental disorders
2015
Positive Attributes Buffer the Negative Associations Between Low Intelligence and High Psychopathology With Educational Outcomes
Hoffmann M, Leibenluft E, Stringaris A, Laporte P, Pan P, Gadelha A, Manfro G, Miguel E, Rohde L, Salum G. Positive Attributes Buffer the Negative Associations Between Low Intelligence and High Psychopathology With Educational Outcomes. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 55: 47-53. PMID: 26703909, PMCID: PMC4695393, DOI: 10.1016/j.jaac.2015.10.013.Peer-Reviewed Original ResearchConceptsNegative educational outcomesConfirmatory factor analysisEducational outcomesPoor academic performanceLow intelligenceHigher psychopathologyAcademic performancePositive attributesNegative school outcomesPsychiatric symptomsHigher psychiatric symptomsDistinct constructsSchool outcomesEducational problemsCommunity sampleDiscriminant validityPsychopathologyNegative effectsFactor analysisIntelligenceMain effectEquation modelNegative associationAttribute changesLow levelsDefault mode network maturation and psychopathology in children and adolescents
Sato J, Salum G, Gadelha A, Crossley N, Vieira G, Manfro G, Zugman A, Picon F, Pan P, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Lacerda A, Rohde L, Miguel E, Jackowski A, Bressan R. Default mode network maturation and psychopathology in children and adolescents. Journal Of Child Psychology And Psychiatry 2015, 57: 55-64. PMID: 26111611, DOI: 10.1111/jcpp.12444.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingChild Behavior ChecklistMental health disordersResting-state protocolPsychopathology scoresHealth disordersBehavior ChecklistDefault modeChild psychopathologyDeviant trajectoriesNeurodevelopmental trajectoriesAge of participantsBrain maturationLow-frequency fluctuationsPsychopathologyChronological ageFractional amplitudeMental disordersDMNGeneral psychopathology scoresNetwork maturationAge predictionChildrenPredictor variablesDisorders
2012
Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety
Diniz J, Miguel E, de Oliveira A, Reimer A, Brandão M, de Mathis M, Batistuzzo M, Costa D, Hoexter M. Outlining new frontiers for the comprehension of obsessive-compulsive disorder: a review of its relationship with fear and anxiety. Brazilian Journal Of Psychiatry 2012, 34: 81-91. PMID: 22729451, DOI: 10.1590/s1516-44462012000500007.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnxiety disordersExpression of fearTypes of obsessionsAnimal anxiety modelsFear conditioningCortico-striatal pathwaysFunctional neuroimagingNeurobiological studiesAnxiety modelsOCD patientsOCD onsetExtinction processAnxietyRelevant dimensionsMost interventionsFearDisordersDegree of overlapTreatment responsePsychopathologyComprehensionNeurocircuitryFunctioningFuture studies