2022
Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium
Fouche J, Groenewold N, Sevenoaks T, Heany S, Lochner C, Alonso P, Batistuzzo M, Cardoner N, Ching C, de Wit S, Gutman B, Hoexter M, Jahanshad N, Kim M, Kwon J, Mataix‐Cols D, Menchon J, Miguel E, Nakamae T, Phillips M, Pujol J, Sakai Y, Yun J, Soriano‐Mas C, Thompson P, Yamada K, Veltman D, van den Heuvel O, Stein D. Shape analysis of subcortical structures in obsessive‐compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta‐analysis by the OCD Brain Imaging Consortium. Brain And Behavior 2022, 12: e2755. PMID: 36106505, PMCID: PMC9575597, DOI: 10.1002/brb3.2755.Peer-Reviewed Original ResearchConceptsCaudate nucleusHealthy controlsOCD patientsComorbid depressionMedication statusComorbid anxietySubcortical shapeSignificant differencesDeep gray matter structuresRight caudate nucleusCo-morbid anxietyLeft caudate nucleusObsessive-compulsive disorder patientsSubcortical brain morphologyGray matter structuresDisease durationMedication useObsessive-compulsive disorderSubgroup analysisBrain MRINucleus accumbensDisorder patientsPatientsBrain volumePutamenAssociations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
Ivanov I, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Balachander S, Baker JT, Banaj N, Bargalló N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Diniz JB, Ely BA, Feusner JD, Ferreira S, Fitzgerald KD, Fontaine M, Gruner P, Hanna GL, Hirano Y, Hoexter MQ, Huyser C, Ikari K, James A, Jaspers-Fayer F, Jiang H, Kathmann N, Kaufmann C, Kim M, Koch K, Kwon JS, Lázaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, Oh S, Perriello C, Piacentini JC, Picó-Pérez M, Piras F, Piras F, Reddy YCJ, Manrique DR, Sakai Y, Shimizu E, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, van Rooij D, Veltman DJ, van der Werf YD, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zarei M, Zhang F, Zhao Q, Jahanshad N, Thomopoulos SI, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, Group T, Poletti S, Fridgeirsson E, Ikuta T, de Wit S, Vriend C, Kasprzak S, Kuno M, Takahashi J, Miguel E, Shavitt R, Hough M, Pariente J, Ortiz A, Bertolín S, Real E, Segalàs C, Moreira P, Sousa N, Narumoto J, Yamada K, Tang J, Fouche J, Kim T, Choi S, Ha M, Park S. Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium. Journal Of Affective Disorders 2022, 318: 204-216. PMID: 36041582, DOI: 10.1016/j.jad.2022.08.084.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderUnmedicated patientsOlder adultsAssociation of medicationVolumes of putamenSubcortical brain structuresReuptake inhibitorsVentricular hypertrophyHippocampal atrophyMedicated patientsPsychotropic medicationsTherapeutic responseHippocampal volumeStriatal volumeSubcortical nucleiPatientsPsychotic disordersAntipsychoticsSubcortical morphologyStructural MRINormal agingBrain structuresBenzodiazepinesOCD patientsENIGMA consortiumLatency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample
Costa D, de Campos A, Pereira C, Torres A, Dos Santos A, Requena G, Ferrão Y, do Rosário M, Miguel E, Simpson H, Shavitt R, Diniz J. Latency to treatment seeking in patients with obsessive-compulsive disorder: Results from a large multicenter clinical sample. Psychiatry Research 2022, 312: 114567. PMID: 35490573, DOI: 10.1016/j.psychres.2022.114567.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly onsetOne-thirdCross-sectional studyInterval-censored survival modelClinical characteristicsOlder patientsSymptom awarenessPatientsNeuropsychiatric disordersSymptomsOlder ageOCD patientsContamination/Clinical samplesDisordersAggression symptomsOCD symptomsMore yearsTreatmentSurvival modelsOnsetYearsFull-time employmentComorbiditiesClinical characteristics of transformation obsessions in obsessive-compulsive disorder: A psychopathological study
Bettess Z, Albertella L, Destree L, Rosário M, Ferrão Y, Miguel E, Fontenelle L. Clinical characteristics of transformation obsessions in obsessive-compulsive disorder: A psychopathological study. Australian & New Zealand Journal Of Psychiatry 2022, 57: 130-139. PMID: 35303769, DOI: 10.1177/00048674221084241.Peer-Reviewed Original Research
2021
Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation
de Oliveira K, Camilo C, Gastaldi V, Sant’Anna Feltrin A, Lisboa B, de Jesus Rodrigues de Paula V, Moretto A, Lafer B, Hoexter M, Miguel E, Maschietto M, Brentani H. Brain areas involved with obsessive-compulsive disorder present different DNA methylation modulation. BMC Genomic Data 2021, 22: 45. PMID: 34717534, PMCID: PMC8557022, DOI: 10.1186/s12863-021-00993-0.Peer-Reviewed Original ResearchConceptsGene modulesMethylation changesBrain areasCpG sitesProtein-protein interaction networkDNA methylation modulationCommon transcriptional factorsDNA methylation changesSpecific signaling pathwaysGene expression dataOCD patientsPost-mortem brain tissueEpigenetic mechanismsInteraction networksMethylation modulationHypomethylation patternTranscriptional factorsEnvironmental risk factorsGene expressionBiological processesBackgroundObsessive–compulsive disorderSignaling pathwaysExpression dataG proteinsRisk factorsHow do daily routines and situational factors affect the severity of obsessive-compulsive disorder?
Brierley M, Albertella L, do Rosário M, Ferrão Y, Miguel E, Fontenelle L. How do daily routines and situational factors affect the severity of obsessive-compulsive disorder? Journal Of Psychiatric Research 2021, 143: 395-399. PMID: 34600268, DOI: 10.1016/j.jpsychires.2021.09.040.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOCD symptom severitySymptom severityOCD symptomsOCD patientsSevere OCD symptomsYale-Brown ObsessiveCross-sectional designReport symptomsHistory questionnaireCommon biological abnormalitiesBiological abnormalitiesClinical implicationsSymptomsDaily routineCompulsive ScaleSeverityMultivariate regressionPatientsRoutine factorsDisordersNeurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review
Vieira E, Arantes P, Hamani C, Iglesio R, Duarte K, Teixeira M, Miguel E, Lopes A, Godinho F. Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review. Frontiers In Psychiatry 2021, 12: 680484. PMID: 34276448, PMCID: PMC8280498, DOI: 10.3389/fpsyt.2021.680484.Peer-Reviewed Original ResearchDeep brain stimulationObsessive-compulsive disorderBrain stimulationEffects of DBSMechanisms of DBSRefractory obsessive-compulsive disorderOCD patientsVentral anterior limbDifferent white matter pathwaysCorresponding clinical outcomesDiffusion-weighted imagingDifferent fiber tractsDiffusion tensor imagingPostoperative periodWhite matter pathwaysClinical outcomesInternal capsuleFavorable outcomeDBS effectsDTI-MRIAnterior limbAffective symptomsElectronic databasesWhite matterPatients
2020
Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls
Stamatis C, Batistuzzo M, Tanamatis T, Miguel E, Hoexter M, Timpano K. Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls. British Journal Of Clinical Psychology 2020, 60: 77-98. PMID: 33300635, DOI: 10.1111/bjc.12272.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNeuropsychological literatureNeuropsychological processesSensory phenomenaOCD patientsDistinct cognitive processesDifferent cognitive profilesExecutive function deficitsDistinct neuropsychological featuresCognitive processesNeuropsychological paradigmsCognitive profileNeuropsychological dataFunction deficitsNeuropsychological featuresHealthy controlsMultiple analytic approachesPatient subsampleSymptom presentationCommon experienceSymptom-based approachEmpirical findingsDistinct drivesRisk sensitivityMotivationStressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study
Imthon A, Caldart C, do Rosário M, Fontenelle L, Miguel E, Ferrão Y. Stressful Life Events and the Clinical Expression of Obsessive–Compulsive Disorder (OCD): An Exploratory Study. Journal Of Clinical Medicine 2020, 9: 3371. PMID: 33096706, PMCID: PMC7590000, DOI: 10.3390/jcm9103371.Peer-Reviewed Original ResearchStressful life eventsObsessive-compulsive disorderPost-traumatic stress disorderOCD patientsOccurrence of SLEsNonwhite skin colorLife eventsLogistic regression variablesCross-sectional studySensory phenomenaYale-Brown ObsessiveClinical characteristicsClinical expressionPsychiatric disordersHistory questionnairePatientsObsessive-compulsive symptomsStress disorderCompulsive ScaleDimensional Yale-Brown ObsessiveStatistical significanceDisordersPositive associationOCD symptomsSymptomsIntelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder
Batistuzzo M, de Marco e Souza M, Bernardes E, Requena G, Miguel E, Shavitt R. Intelligence quotient (IQ) in pediatric patients with obsessive-compulsive disorder. Journal Of Obsessive-Compulsive And Related Disorders 2020, 26: 100548. DOI: 10.1016/j.jocrd.2020.100548.Peer-Reviewed Original ResearchObsessive-compulsive disorderIntelligence quotientProcessing speedGroup differencesFull-scale intelligence quotientWechsler Abbreviated ScalePerformance intelligence quotientVerbal intelligence quotientBlock Design TestAbbreviated ScaleIntellectual efficiencyImpaired performanceIQ discrepanciesSubtest scoresPIQ scoresIntellectual quotientOCD patientsIntelligence evaluationVIQAverage rangeDesign testMultiple comparison correctionAdult literatureFSIQLarge sampleAttentional Bias in specific symmetry and cleaning dimensions of obsessive-compulsive disorder
De Mathis M, Batistuzzo M, Bar-Haim Y, Abend R, Miguel E, Morais I, Requena G, Salum G, Shavitt R. Attentional Bias in specific symmetry and cleaning dimensions of obsessive-compulsive disorder. Journal Of Anxiety Disorders 2020, 73: 102238. PMID: 32447225, DOI: 10.1016/j.janxdis.2020.102238.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAttentional biasAB scoresComputerized dot-probe taskSymptoms of OCDDot-probe taskAllocation of attentionThreat stimuliNeutral stimuliTask conditionsOCD dimensionsOCD patientsDemographic variablesStimuliPositive interactionsNeutral conditionsMixed-effects modelsHealthy controlsIQDisordersBiasTaskScoresSymptomsPictureObsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD
Copetti M, Lopes A, Requena G, Johnson I, Greenberg B, Noren G, McLaughlin N, Shavitt R, Miguel E, Batistuzzo M, Hoexter M. Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD. Frontiers In Psychiatry 2020, 10: 936. PMID: 31998155, PMCID: PMC6962231, DOI: 10.3389/fpsyt.2019.00936.Peer-Reviewed Original ResearchGamma ventral capsulotomyPersonality disorder symptomsIntractable obsessive-compulsive disorderObsessive-compulsive disorderDisorder symptomsOCD patientsTreatment responseDisorder symptom changeSymptom changeStructured Clinical InterviewWorse treatment responseDSM-IV personality disordersWilcoxon signed-rank testPoorer ResponseClinical responseTreatment optionsInternal capsuleSigned-rank testTreatment attemptsAnterior limbClinical InterviewRadiosurgical proceduresPatientsSymptomsVentral part
2019
Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity
de Oliveira Santos B, Gorgulho A, Saraiva C, Lopes A, Gomes J, Pássaro A, Hoexter M, Miguel E, De Salles A. Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity. Surgical Neurology International 2019, 10: 136. PMID: 31528471, PMCID: PMC6744751, DOI: 10.25259/sni-65-2019.Peer-Reviewed Original ResearchDiffusion tensor image tractographyMorbid obesity patientsOCD patientsObesity patientsInternal capsuleOrbitofrontal cortexAnterior internal capsuleGamma ventral capsulotomyMedial orbitofrontal cortexFunctional stereotactic proceduresFunctional patientsMorbid obesityMean ageTract fibersAnterior limbCerebral hemispheresPatientsFiber tractsDisorder individualsStereotactic proceduresDeep brain stimulation implantsObesityTractography parametersExact topographyTractographyNo evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder
Skinazi M, de Mathis M, Cohab T, de Marco e Souza M, Shavitt R, Miguel E, Hoexter M, Batistuzzo M. No evidence of attentional bias toward angry faces in patients with obsessive-compulsive disorder. Brazilian Journal Of Psychiatry 2019, 41: 257-260. PMID: 30540026, PMCID: PMC6794136, DOI: 10.1590/1516-4446-2018-0130.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAttentional biasAngry facesAnxiety disorder patientsOCD patientsDifferent brain activation patternsFunctional neuroimaging protocolsSpecific OCD symptom dimensionsBrain activation patternsSymptom severityOCD symptom dimensionsDisorder patientsAB taskAB paradigmTransdiagnostic approachAB scoresIntelligence testingAnxiety disordersSymptom dimensionsActivation patternsNeuroimaging protocolPsychiatric comorbidityOne-sample t-testFaceDisordersThe impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2017
Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group
Boedhoe PSW, Schmaal L, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Calvo R, Cheng Y, Cho KIK, Ciullo V, Dallaspezia S, Denys D, Feusner JD, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Jahanshad N, James A, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy JC, Nishida S, Nurmi E, O’Neill J, Piacentini J, Piras F, Piras F, Reddy YCJ, Reess TJ, Sakai Y, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, van Wingen GA, Venkatasubramanian G, Walitza S, Wang Z, Yun JY, Thompson P, Stein D, van den Heuvel O, Boedhoe P, Schmaal L, Abe Y, Alonso P, Ameis S, Anticevic A, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Bollettini I, Bose A, Brandeis D, Brem S, Buimer E, Busatto G, Calvo A, Calvo R, Cheng Y, Cho K, Ciullo V, Dallaspezia S, de Vries F, de Wit S, Denys D, Drechsler R, Falini A, Fang Y, Feusner J, Figee M, Fitzgerald K, Fontaine M, Fouche J, Fridgeirsson E, Gruner P, Hanna G, Hauser T, Hibar D, Hoexter M, Hu H, Huyser C, Iorio M, Jahanshad N, James A, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, McCracken J, Menchón J, Miguel E, Minuzzi L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Narumoto J, Nishida S, Nurmi E, O’Neill J, Pariente J, Piacentini J, Pittenger C, Piras F, Piras F, Poletti S, Reddy Y, Reess T, Rus O, Sakai Y, Sato J, Simpson H, Soreni N, Soriano-Mas C, Spalletta G, Stevens M, Szeszko P, Tang J, Tolin D, van der Werf Y, van Wingen G, Vecchio D, Veltman D, Venkatasubramanian G, Walitza S, Wang Z, Watanabe A, Xu J, Xu X, Yamada K, Yun J, Zarei M, Zhao Q, Thompson P, Stein D, van den Heuvel O. Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. American Journal Of Psychiatry 2017, 175: 453-462. PMID: 29377733, PMCID: PMC7106947, DOI: 10.1176/appi.ajp.2017.17050485.Peer-Reviewed Original ResearchConceptsPediatric OCD patientsAdult OCD patientsOCD patientsParietal cortexAdult obsessive-compulsive disorderCortical thickness abnormalitiesD effectsInferior parietal cortexSuperior parietal cortexLimited statistical powerTransverse temporal cortexCohen's d effectClinical characteristicsCortical abnormalitiesObsessive-compulsive disorderThickness abnormalitiesHealthy controlsCortical thicknessPatientsTemporal cortexThinner cortexMRI scansClinical heterogeneityStructural abnormalitiesDisease profileFear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle
Reimer A, de Oliveira A, Diniz J, Hoexter M, Miguel E, Milad M, Brandão M. Fear extinction in an obsessive-compulsive disorder animal model: Influence of sex and estrous cycle. Neuropharmacology 2017, 131: 104-115. PMID: 29225044, DOI: 10.1016/j.neuropharm.2017.12.015.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderFear extinctionOCD patientsTreatment of OCDFear extinction retentionExtinction retention deficitsFear extinction trainingOCD pathophysiologyOCD-like symptomsAnterior cingulate cortexFear inhibitionExtinction retentionAccount sex differencesEstrous cycleExtinction trainingRetention deficitsRepetitive behaviorsDistinct neurotransmitter systemsMedial prefrontalUntreated OCD patientsCingulate cortexAnimal modelsSelf-grooming behaviorBrain areasEstrous cycle phasePersonality measures after gamma ventral capsulotomy in intractable OCD
Paiva R, Batistuzzo M, McLaughlin N, Canteras M, de Mathis M, Requena G, Shavitt R, Greenberg B, Norén G, Rasmussen S, Tavares H, Miguel E, Lopes A, Hoexter M. Personality measures after gamma ventral capsulotomy in intractable OCD. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 81: 161-168. PMID: 29100975, DOI: 10.1016/j.pnpbp.2017.10.023.Peer-Reviewed Original Research
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatientsNEUROPSYCHOLOGICAL PREDICTORS OF TREATMENT RESPONSE TO COGNITIVE BEHAVIORAL GROUP THERAPY IN OBSESSIVE–COMPULSIVE DISORDER
Braga D, Abramovitch A, Fontenelle L, Ferrão Y, Gomes J, Vivan A, Ecker K, Bortoncello C, Mittelman A, Miguel E, Trentini C, Cordioli A. NEUROPSYCHOLOGICAL PREDICTORS OF TREATMENT RESPONSE TO COGNITIVE BEHAVIORAL GROUP THERAPY IN OBSESSIVE–COMPULSIVE DISORDER. Depression And Anxiety 2016, 33: 848-861. PMID: 27100799, DOI: 10.1002/da.22509.Peer-Reviewed Original ResearchConceptsCognitive-behavioral group therapyObsessive-compulsive disorderBehavioral group therapyNeuropsychological test performanceTest performanceNeuropsychological domainsCBGT groupGroup therapyOCD patientsNeuropsychological outcome measuresNeuropsychological predictorsNeuropsychological functioningNeuropsychological measuresOCD symptomsNeurocognitive functionDepression symptomsTreatment respondersTreatment responseParticipantsAvailable researchInconsistent resultsDisordersPredictorsAnxietyMeasures