2015
Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. FOCUS The Journal Of Lifelong Learning In Psychiatry 2015, 13: 204-212. DOI: 10.1176/appi.focus.130210.Peer-Reviewed Original ResearchHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsMatter volumeGreater cerebellar gray matter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeCerebellar gray matter volumeVoxel-based morphometryAdult OCD patientsAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexMRI scans
2014
Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder
de Wit S, Alonso P, Schweren L, Mataix-Cols D, Lochner C, Menchón J, Stein D, Fouche J, Soriano-Mas C, Sato J, Hoexter M, Denys D, Nakamae T, Nishida S, Kwon J, Jang J, Busatto G, Cardoner N, Cath D, Fukui K, Jung W, Kim S, Miguel E, Narumoto J, Phillips M, Pujol J, Remijnse P, Sakai Y, Shin N, Yamada K, Veltman D, van den Heuvel O. Multicenter Voxel-Based Morphometry Mega-Analysis of Structural Brain Scans in Obsessive-Compulsive Disorder. American Journal Of Psychiatry 2014, 171: 340-349. PMID: 24220667, DOI: 10.1176/appi.ajp.2013.13040574.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsObsessive-compulsive disorderOCD patientsHealthy subjectsComparison subjectsGreater cerebellar gray matter volumeMatter volumeStructural T1-weighted MRI scansWhite matter brain volumesWhite matter volume differencesT1-weighted MRI scansWhite matter volumePrevious smaller studiesStructural brain scansGray matter volumeVoxel-based morphometryAdult OCD patientsCerebellar gray matter volumeAnterior cingulate cortexAltered neuroplasticityClinical variablesInferior frontal gyrusCognitive dysfunctionDorsomedial prefrontal cortexTemporal cortex
2008
Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study
Cecconi J, Lopes A, de Souza Duran F, Santos L, Hoexter M, Gentil A, Canteras M, de Castro C, Norén G, Greenberg B, Rauch S, Busatto G, Miguel E. Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study. Neuroscience Letters 2008, 447: 138-142. PMID: 18835422, DOI: 10.1016/j.neulet.2008.09.061.Peer-Reviewed Original ResearchConceptsGamma ventral capsulotomyObsessive-compulsive disorderRefractory obsessive-compulsive disorderResistant obsessive-compulsive disorderRefractory OCD patientsYear of radiosurgeryPilot prospective studyVoxel-based morphometry methodRegional structural abnormalitiesGray matter volumeRight inferior frontal gyrusInferior orbitofrontal cortexPostoperative increaseProspective studyInferior frontal gyrusMagnetic resonance imaging dataMatter volumeMRI scansNeurobiological changesStructural abnormalitiesOrbitofrontal cortexCapsulotomyPatientsOCD patientsFrontal gyrus