2017
Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases
Maschietto M, Bastos L, Tahira A, Bastos E, Euclydes V, Brentani A, Fink G, de Baumont A, Felipe-Silva A, Francisco R, Gouveia G, Grisi S, Escobar A, Moreira-Filho C, Polanczyk G, Miguel E, Brentani H. Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases. Scientific Reports 2017, 7: 44547. PMID: 28303968, PMCID: PMC5355991, DOI: 10.1038/srep44547.Peer-Reviewed Original ResearchConceptsDNA methylationCpG sitesSex-specific DNA methylationCord bloodIllumina HumanMethylation450 BeadChipPsychiatric outcomesMethylation profilesSex differencesHumanMethylation450 BeadChipBrains of boysMethylationXY probesPsychiatric disordersPsychiatric diseasesBrain tissueEnvironmental factorsBrain developmentNeurodevelopmental disordersPrimary driverGestationBloodPotential connectionBeadChipDisordersGenes
2006
Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder
Vasconcelos M, Sampaio A, Hounie A, Akkerman F, Curi M, Lopes A, Miguel E. Prenatal, Perinatal, and Postnatal Risk Factors in Obsessive–Compulsive Disorder. Biological Psychiatry 2006, 61: 301-307. PMID: 17123475, DOI: 10.1016/j.biopsych.2006.07.014.Peer-Reviewed Original ResearchConceptsPostnatal risk factorsObsessive-compulsive disorderRisk factorsProlonged laborOCD patientsExcessive weight gainLogistic regression analysisEarly risk factorsHyperemesis gravidarumPreterm birthPrenatal careControl subjectsStandardized questionnaireControl groupWeight gainEdemaSocioeconomic classCompulsive disorderPregnancyPatientsRegression analysisGestationPerinatalGreater frequencyEnvironmental factors