2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathers
2019
Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents
Axelrud L, Sato J, Santoro M, Talarico F, Pine D, Rohde L, Zugman A, Junior E, Bressan R, Grassi-Oliveira R, Pan P, Hoffmann M, Simioni A, Guinjoan S, Hakonarson H, Brietzke E, Gadelha A, Pellegrino da Silva R, Hoexter M, Miguel E, Belangero S, Salum G. Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents. Neurobiology Of Aging 2019, 82: 10-17. PMID: 31376729, PMCID: PMC7658444, DOI: 10.1016/j.neurobiolaging.2019.06.011.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD-PRSBrain connectivityGenetic riskRight superior temporal gyrusFunctional brain connectivityMagnetic resonance imagingInhibitory controlSuperior temporal gyrusTau pathologyAD developmentPolygenic risk scoresRisk scoreRight precuneusResonance imagingTau proteinTemporal gyrusDiseaseBrain connectionsEarly lifePathology networkFunctional networksRiskPorto AlegreMemory performance
2018
Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life
Axelrud L, Santoro M, Pine D, Talarico F, Gadelha A, Manfro G, Pan P, Jackowski A, Picon F, Brietzke E, Grassi-Oliveira R, Bressan R, Miguel E, Rohde L, Hakonarson H, Pausova Z, Belangero S, Paus T, Salum G. Polygenic Risk Score for Alzheimer’s Disease: Implications for Memory Performance and Hippocampal Volumes in Early Life. American Journal Of Psychiatry 2018, 175: 555-563. PMID: 29495896, PMCID: PMC6372950, DOI: 10.1176/appi.ajp.2017.17050529.Peer-Reviewed Original ResearchConceptsHippocampal volumeEarly-life cognitionCanadian sampleMemory taskCognitive abilitiesExecutive functionImmediate recallMemory performanceCognitive testsGenetic riskReplication sampleBrain algorithmPolygenic risk scoresStandardized testsLower hippocampal volumeDistinct tasksBrain structuresAlzheimer's diseaseCognitionIndependent samplesLate-life dementiaDevelopmental conditionsRecallPrevious evidenceTask
2014
An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder
Cappi C, Hounie A, Mariani D, Diniz J, Silva A, Reis V, Busso A, Silva A, Fidalgo F, Rogatto S, Miguel E, Krepischi A, Brentani H. An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder. PLOS ONE 2014, 9: e110198. PMID: 25303678, PMCID: PMC4193873, DOI: 10.1371/journal.pone.0110198.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetCase-Control StudiesChildChild, PreschoolChromosome DeletionChromosomes, Human, Pair 15Comparative Genomic HybridizationDNA Copy Number VariationsFetal ProteinsForminsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMicrofilament ProteinsNuclear ProteinsObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderOnset obsessive-compulsive disorderEarly-onset obsessive-compulsive disorderAttention deficit hyperactivity disorderArray-based comparative genomic hybridizationNeurodevelopmental psychiatric disordersDeficit hyperactivity disorderGlutamatergic involvementMale patientsGlutamatergic systemPsychiatric disordersHealthy individualsPatientsHyperactivity disorderGenetic riskComparative genomic hybridizationDisordersSmall microdeletionsChromosome 15q13.3Present studyGenomic hybridizationMicrodeletionCohort