2004
The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello R, Karatekin E, Kleinman M, Turro N, Hornykiewicz O, Zucca F. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 9843-9848. PMID: 15210960, PMCID: PMC470762, DOI: 10.1073/pnas.0403495101.Peer-Reviewed Original ResearchConceptsSubstantia nigraLocus coeruleusLC neuronsNeuronal vulnerabilityParkinson's diseaseCopper/zinc SODZinc SODCompacta neuronsParkinsonian syndromesBrainstem nucleiManganese superoxide dismutaseGlial cellsMajor molecular formCeruloplasmin levelsNormal subjectsRelated disordersRole of ironLight chain ferritinNeuronsDiseaseManganese SODFerritinNeuromelaninCoeruleusNM concentrations
2000
Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
Sulzer D, Bogulavsky J, Larsen K, Behr G, Karatekin E, Kleinman M, Turro N, Krantz D, Edwards R, Greene L, Zecca L. Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11869-11874. PMID: 11050221, PMCID: PMC17261, DOI: 10.1073/pnas.97.22.11869.Peer-Reviewed Original ResearchConceptsCytosolic catecholaminesSubstantia nigraDisease neurodegenerationCytosolic dopamineRat substantia nigraSynaptic vesiclesParkinson's disease neurodegenerationHuman substantia nigraIron chelator desferrioxamineCatecholamine neuronsFunction of neuromelaninDeep brain regionsParkinson's diseaseAdenoviral-mediated overexpressionBrain regionsDouble-membrane autophagic vacuolesVesicular accumulationPC12 cell culturesChelator desferrioxamineDopamineNM granulesAntioxidant mechanismsPC12 cellsNeuromelaninNeurite outgrowth