2024
Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis
Woodward M, Kardon A, Manners J, Schleicher S, Pergakis M, Ciryam P, Podell J, Denney Zimmerman W, Galvagno S, Butt B, Pritchard J, Parikh G, Gilmore E, Badjatia N, Morris N. Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis. Epilepsy & Behavior Reports 2024, 25: 100645. PMID: 38299124, PMCID: PMC10827579, DOI: 10.1016/j.ebr.2024.100645.Peer-Reviewed Original ResearchRefractory status epilepticusNeurocritical care unitEtomidate inductionStatus epilepticusSingle-center retrospective analysisSingle-center retrospective reviewRapid sequence intubationHospital intubationPrimary endpointSeizure cessationAnesthetic medicationsCare unitElectrographic seizuresRetrospective reviewEndotracheal intubationSequence intubationInduction agentRetrospective analysisIntubationHigh incidencePatientsLogistic regressionSeizuresEnriched populationEpilepticus
2021
The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill Patients
Fong M, Jadav R, Alzawahmah M, Hussein O, Gilmore E, Hirsch L. The Significance of LRDA With Bilateral Involvement Compared With GRDA on EEG in Critically Ill Patients. Journal Of Clinical Neurophysiology 2021, 40: 434-442. PMID: 37399042, DOI: 10.1097/wnp.0000000000000897.Peer-Reviewed Original ResearchConceptsLateralized rhythmic delta activityGroup of patientsRhythmic delta activityFocal abnormalitiesDelta activitySporadic epileptiform dischargesCritically Ill PatientsFocal electrographic seizuresComputed tomography scanClear etiologyIschemic strokeBilateral involvementIll patientsMetabolic encephalopathiesElectrographic seizuresImaging findingsFocal slowingCortical excitabilitySubdural hemorrhageTomography scanEpileptiform dischargesPatientsControl groupSeizuresContinuous EEG
2019
Comparison of machine learning models for seizure prediction in hospitalized patients
Struck AF, Rodriguez‐Ruiz A, Osman G, Gilmore EJ, Haider HA, Dhakar MB, Schrettner M, Lee JW, Gaspard N, Hirsch LJ, Westover MB, Consortium C. Comparison of machine learning models for seizure prediction in hospitalized patients. Annals Of Clinical And Translational Neurology 2019, 6: 1239-1247. PMID: 31353866, PMCID: PMC6649418, DOI: 10.1002/acn3.50817.Peer-Reviewed Original ResearchConceptsLow-risk patientsNegative predictive valueEvaluation cohortContinuous EEGElastic net logistic regressionMulticenter databaseRisk stratificationSeizure riskPatientsPredictive valueComparable AUCSecondary analysisLogistic regressionCohortFirst hourSeizure predictionEEG recordingsEEGRisk calibrationLarge proportionSeizuresComplex neural networks
2018
T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study
Osman G, Rahangdale R, Britton J, Gilmore E, Haider H, Hantus S, Herlopian A, Hocker S, Lee J, Legros B, Punia V, Rampal N, Szaflarski J, Wallace A, Westover M, Hirsch L, Gaspard N. T62. Bilateral independent periodic discharges are associated with electrographic seizures and poor outcome: A case-control study. Clinical Neurophysiology 2018, 129: e25-e26. DOI: 10.1016/j.clinph.2018.04.063.Peer-Reviewed Original ResearchBilateral independent periodic dischargesCase-control studyRetrospective case-control studyElectrographic seizuresBrain injuryPeriodic dischargesPoor outcomePD groupHospital mortality rateAcute brain injuryAnoxic brain injuryCNS infectionsFrequent etiologyLPD groupHemorrhagic strokeClinical correlatesWorse outcomesLevel of alertnessHigh riskBetter outcomesMortality rateControl groupMultivariate analysisSeizuresEEG patterns
2017
Seizures and Status Epilepticus
Harris C, Gilmore E. Seizures and Status Epilepticus. 2017, 201-221. DOI: 10.1007/978-3-319-48669-7_12.Peer-Reviewed Original Research
2016
Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes
Maciel CB, Gilmore EJ. Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes. Journal Of Clinical Neurophysiology 2016, 33: 183-195. PMID: 27258441, DOI: 10.1097/wnp.0000000000000268.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageAssociation of seizuresMedication side effectsImpact of seizuresSevere subarachnoid hemorrhageRisk-benefit ratioSeizure prophylaxisAntiepileptic treatmentDifferent time pointsNeurovascular complicationsYounger patientsInterictal patternsHeterogeneous pathophysiologyNeurophysiologic monitoringSubclinical seizuresCortical irritationNew anticonvulsantsTherapeutic dosingTherapeutic approachesHigh riskSide effectsFavorable profileEpileptiform patternsSeizuresBurden quantification
2015
Status epilepticus epidemiology—tracking a moving target
Gilmore EJ, Hirsch LJ. Status epilepticus epidemiology—tracking a moving target. Nature Reviews Neurology 2015, 11: 377-378. PMID: 26100743, DOI: 10.1038/nrneurol.2015.104.Peer-Reviewed Original Research