2024
Massive thymic hyperplasia in a toddler masquerading as a loculated pleural effusion: A case report
Zolfaghari E, Shaughnessy M, Wu H, Caty M, Christison-Lagay E, Hornick M. Massive thymic hyperplasia in a toddler masquerading as a loculated pleural effusion: A case report. Journal Of Pediatric Surgery Case Reports 2024, 110: 102885. DOI: 10.1016/j.epsc.2024.102885.Peer-Reviewed Original ResearchMassive thymic hyperplasiaChest X-rayThymic hyperplasiaCase reportComputed tomographyDifferential diagnosis of pediatric patientsSurveillance chest x-raysDiagnosis of pediatric patientsTrue thymic hyperplasiaRecurrent respiratory distressPost-operative coursePercutaneous core biopsyLoculated pleural effusionHistory of multiple admissionsPersistent respiratory symptomsSurgical resectionCore biopsyParapneumonic effusionPediatric patientsAbnormal findingsPleural effusionRight thoracotomyRare conditionRight hemithoraxSuspected pneumoniaSurgical Incisions in Pediatric Surgical Oncology
Christison-Lagay E. Surgical Incisions in Pediatric Surgical Oncology. 2024, 45-52. DOI: 10.1007/978-3-031-65890-7_9.Peer-Reviewed Original ResearchMinimally invasive approachResection of Wilms' tumorTreatment of pediatric cancersPediatric surgical oncologyLymph node resectionLymph node yieldSuperior mesenteric artery rootLymph node samplingLaparoscopic resectionThoracoabdominal approachNode resectionUnder-stagingNode yieldWilms tumorOncologic resectionSurgical approachSurgical treatmentArterial rootsInvasive approachSurgical incisionDistal aortaPoor outcomeResectionSurgical oncologyNode samplingEvaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group.
Sargen M, Barnhill R, Elder D, Swetter S, Prieto V, Ko J, Bahrami A, Gerami P, Karunamurthy A, Pappo A, Schuchter L, LeBoit P, Yeh I, Kirkwood J, Jen M, Dunkel I, Durham M, Christison-Lagay E, Austin M, Aldrink J, Mehrhoff C, Hawryluk E, Chu E, Busam K, Sondak V, Messina J, Puig S, Colebatch A, Coughlin C, Berrebi K, Laetsch T, Mitchell S, Seynnaeve B. Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group. Journal Of Clinical Oncology 2024, jco2401154. PMID: 39365959, DOI: 10.1200/jco.24.01154.Peer-Reviewed Original ResearchSentinel lymph node biopsyAtypical Spitz tumorsCutaneous melanomaSpitz tumorsRe-excisionSurgical managementMelanocytic tumorsSurgical management of cutaneous melanomaManagement of cutaneous melanomaNational Comprehensive Cancer Network guidelinesLymph node biopsyDefinitive surgical treatmentProgression to CMChildren's Oncology GroupDiagnosis of CMNode biopsyExcisional biopsyOncology GroupMalignant potentialSurgical treatmentNetwork guidelinesBiopsyClinicopathological evaluationCohort studyMelanocytic neoplasmsFeasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee
Mitchell S, Christison‐Lagay E, Aldrink J, Sargen M, Laetsch T, Austin M, Jen M, Gartrell R, Karunamurthy A, Kirkwood J, Pappo A, Seynnaeve B. Feasibility of a prospective pediatric melanocytic tumor clinical trial: A report of multidisciplinary clinician survey data from the Children's Oncology Group Rare Tumor Committee. Pediatric Blood & Cancer 2024, 71: e31312. PMID: 39252525, PMCID: PMC11583290, DOI: 10.1002/pbc.31312.Peer-Reviewed Original ResearchAbstract B023: Multicenter histology image integration and multiscale deep learning for pediatric sarcoma subtype classification
Thiesen A, Domanskyi S, Foroughi pour A, Sheridan T, Neuhauser S, Stetson A, Dannheim K, Cameron D, Ahn S, Wu H, Christison-Lagay E, Bult C, Chuang J, Rubinstein J. Abstract B023: Multicenter histology image integration and multiscale deep learning for pediatric sarcoma subtype classification. Cancer Research 2024, 84: b023-b023. DOI: 10.1158/1538-7445.pediatric24-b023.Peer-Reviewed Original ResearchArtificial neural networkFeature extractionDeep learningTile sizeDeep learning feature extractionConvolutional artificial neural networksHistology datasetDeep learning backbonesTraining of artificial neural networksLearning feature extractionNon-overlapping tilesImage integrationImage format conversionFeature concatenationStain normalizationTiling parametersClassification performanceANN classifierClassification accuracyNeural networkAutomated classificationTraining modelDigitization of histology slidesFormat conversionDatasetSurgical management of rare tumors (Part 1)
Stetson A, Saluja S, Cameron D, Mansfield S, Polites S, Honeyman J, Dahl J, Austin M, Aldrink J, Christison‐Lagay E. Surgical management of rare tumors (Part 1). Pediatric Blood & Cancer 2024, e31287. PMID: 39185712, DOI: 10.1002/pbc.31287.Peer-Reviewed Original ResearchOncology GroupManagement of rare tumorsEuropean Cooperative Study GroupDifferentiated thyroid cancerRare tumor typeRare pediatric cancerChildren's Oncology GroupCooperative Study GroupCooperative group effortsChildren aged 0Rare tumorAdult guidelinesSurgical managementThyroid cancerTumor typesRare cancersPediatric variantsTreatment strategiesStudy groupPediatric cancerCancer typesCancerTumorChildhood cancerAged 0Synoptic operative reports for pediatric surgical oncology
Baertschiger R, Polites S, Fusco J, Roach J, Christison‐Lagay E, Malek M, Gow K. Synoptic operative reports for pediatric surgical oncology. Pediatric Blood & Cancer 2024, e31280. PMID: 39152638, DOI: 10.1002/pbc.31280.Peer-Reviewed Original ResearchImprove patient care outcomesElectronic medical record systemMultidisciplinary healthcare teamPatient care outcomesSurgical oncologySynoptic operative reportMedical record systemCare outcomesHealthcare teamPediatric surgical oncologyQuality assurance effortsDocumentation practicesData extractionDocumentation of surgical proceduresEffective communicationSynoptic reportingOperative notesRecording systemAssurance effortsEnhanced accessOncologyTumor characteristicsOperative reportsPediatric patientsResearch purposesEvaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee
Kulaylat A, Lucas D, Chang H, Derderian S, Beres A, Ham P, Huerta C, Sulkowski J, Wakeman D, Englum B, Gulack B, Acker S, Gonzalez K, Levene T, Christison-Lagay E, Mansfield S, Yousef Y, Pennell C, Russell K, Rentea R, Tashiro J, Diesen D, Alemayehu H, Ricca R, Kelley-Quon L, Rialon K. Evaluation and Management of Biliary Dyskinesia in Children and Adolescents: A Systematic Review From the APSA Outcomes and Evidence-Based Committee. Journal Of Pediatric Surgery 2024, 59: 161678. PMID: 39227244, DOI: 10.1016/j.jpedsurg.2024.08.018.Peer-Reviewed Original ResearchSystematic reviewBiliary dyskinesiaOxford Levels of EvidencePreferred Reporting ItemsGrading of RecommendationsAmerican Pediatric Surgical Association OutcomesRisk of biasEvidence-based recommendationsDiagnostic criteriaPredictors of symptom reliefLevel of evidenceNon-operative managementResolution of symptomsPediatric-specific guidelinesOutcome of medical managementLong-term outcomesReporting ItemsNon-randomized studiesOxford LevelsMeta-analysesMethodological IndexAssociated outcomesClinical entityProspective studySymptom reliefCurrent surgical practice for central venous access to deliver chemotherapy and enteral access for nutritional support in pediatric patients with an oncological diagnosis
van den Bosch C, Grant C, Brown E, Morrison Z, Luques L, Christison‐Lagay E, Baertschiger R. Current surgical practice for central venous access to deliver chemotherapy and enteral access for nutritional support in pediatric patients with an oncological diagnosis. Pediatric Blood & Cancer 2024, e31206. PMID: 39030929, DOI: 10.1002/pbc.31206.Peer-Reviewed Original ResearchCentral venous catheterCentral venous accessPediatric patientsEnteral accessVenous accessNutritional supportTunneled central venous cathetersParenteral nutrition deliveryAdministration of chemotherapyLong-term outcomesCurrent surgical practiceDeterminants of outcomeSurgical oncology patientsModern oncology practiceCentral venous catheter managementDeliver chemotherapyVenous cathetersNutrition deliveryNutritional assessmentAccess surgerySurgical perspectiveOncological diagnosisOncology patientsNutritional statusSurgical practiceImplementing Screening, Brief Interventions, and Referral to Treatment at Pediatric Trauma Centers: A Step Wedge Cluster Randomized Trial
Mello M, Baird J, Spirito A, Lee L, Kiragu A, Scott K, Zonfrillo M, Christison-Lagay E, Bromberg J, Ruest S, Pruitt C, Lawson K, Nasr I, Aidlen J, Maxson R, Becker S. Implementing Screening, Brief Interventions, and Referral to Treatment at Pediatric Trauma Centers: A Step Wedge Cluster Randomized Trial. Journal Of Pediatric Surgery 2024, 59: 161618. PMID: 39097494, PMCID: PMC11486576, DOI: 10.1016/j.jpedsurg.2024.07.003.Peer-Reviewed Original ResearchPediatric trauma centerElectronic health recordsReferral to treatmentBrief interventionTrauma centerImplementation strategiesPost-implementationAmerican College of Surgeons criteriaPrimary care providersCluster randomized trialStepped wedge cluster randomized trialCluster randomized designHigh-risk useTrauma patientsDeliver SBIRTLevel of Evidence Level IIAdolescent trauma patientsCare providersImplementation trialImplementing screeningAOD screeningHealth recordsSpecialty servicesPre-implementationEHR dataScreening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review
Kelley-Quon L, Acker S, St Peter S, Goldin A, Yousef Y, Ricca R, Mansfield S, Sulkowski J, Huerta C, Lucas D, Rialon K, Christison-Lagay E, Ham P, Rentea R, Beres A, Kulaylat A, Chang H, Polites S, Diesen D, Gonzalez K, Wakeman D, Baird R. Screening and Prophylaxis for Venous Thromboembolism in Pediatric Surgery: A Systematic Review. Journal Of Pediatric Surgery 2024, 59: 161585. PMID: 38964986, DOI: 10.1016/j.jpedsurg.2024.05.015.Peer-Reviewed Original ResearchIncidence of venous thromboembolismVenous thromboembolismPharmacological prophylaxisSystematic reviewUltrasound screeningEpidemiology of venous thromboembolismAmerican Pediatric Surgical Association OutcomesPreferred Reporting ItemsStudy systematically reviewsLow-molecular-weight heparinRoutine ultrasound screeningCongenital heart diseasePediatric trauma populationPediatric surgical populationBody mass indexPediatric surgical patientsMolecular weight heparinSequential compression devicesInjury Severity ScoreCentral line placementSpinal cord injuryInflammatory bowel diseaseWeb of Science databasesLength of stayReporting ItemsClassification and Surgical Management of Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence-based Practice Committee
Smith C, Rialon K, Kawaguchi A, Dellinger M, Goldin A, Acker S, Kulaylat A, Chang H, Russell K, Wakeman D, Derderian S, Englum B, Polites S, Lucas D, Ricca R, Levene T, Sulkowski J, Kelley-Quon L, Tashiro J, Christison-Lagay E, Mansfield S, Beres A, Huerta C, Ham P, Yousef Y, Rentea R, Committee T. Classification and Surgical Management of Anorectal Malformations: A Systematic Review and Evidence-based Guideline From the APSA Outcomes and Evidence-based Practice Committee. Journal Of Pediatric Surgery 2024, 59: 161598. PMID: 38997855, DOI: 10.1016/j.jpedsurg.2024.06.007.Peer-Reviewed Original ResearchSystematic reviewAnorectal malformationsEvidence-based best practicesSurgical managementConsensus-based questionsComprehensive search strategyPreferred Reporting ItemsComplex patient populationLevel of evidenceAmerican Pediatric Surgical Association OutcomesImprove careDiagnosis of anorectal malformationsGroup of anorectal malformationsTiming of surgical managementManagement of anorectal malformationsReporting ItemsLate repair groupMethod of fecal diversionTreatment of neonatesSurgical careOptimal surgical approachRate of prolapseMulti-institutional registryManagement of childrenSurgical management of anorectal malformationsManagement and Outcomes of Pediatric Lymphatic Malformations: A Systematic Review From the APSA Outcomes and Evidence-Based Practice Committee
Huerta C, Beres A, Englum B, Gonzalez K, Levene T, Wakeman D, Yousef Y, Gulack B, Chang H, Christison-Lagay E, Ham P, Mansfield S, Kulaylat A, Lucas D, Rentea R, Pennell C, Sulkowski J, Russell K, Ricca R, Kelley-Quon L, Tashiro J, Rialon K, Committee T. Management and Outcomes of Pediatric Lymphatic Malformations: A Systematic Review From the APSA Outcomes and Evidence-Based Practice Committee. Journal Of Pediatric Surgery 2024, 59: 161589. PMID: 38914511, DOI: 10.1016/j.jpedsurg.2024.05.019.Peer-Reviewed Original ResearchSystematic reviewLymphatic malformationsConsensus statement of recommendationsPreferred Reporting ItemsEvidence-based recommendationsMedical therapyStatements of recommendationsLevel of Evidence 4Reporting ItemsModerate qualityPediatric lymphatic malformationsMulti-modality treatmentType of LMExtraction of dataConsensus statementOptimal individualized treatmentMacrocystic lesionsComplete responsePercutaneous treatmentMultidisciplinary approachSurgeryMalformationsOutcomesPatientsIndividualized treatmentA Unique Presentation of Nodular Masses in Infancy.
Velagala S, Heiden E, Lisse S, Wu H, Prior D, Chen G, Christison-Lagay E, Provini L, Antaya R, Spencer-Manzon M, Johnston L. A Unique Presentation of Nodular Masses in Infancy. NeoReviews 2024, 25: e370-e374. PMID: 38821908, DOI: 10.1542/neo.25-6-e370.Peer-Reviewed Original ResearchCentral Venous Catheter Consideration in Pediatric Oncology: A Systematic Review and Meta-analysis From the American Pediatric Surgical Association Cancer Committee
Christison-Lagay E, Brown E, Bruny J, Funaro M, Glick R, Dasgupta R, Grant C, Engwall-Gill A, Lautz T, Rothstein D, Walther A, Ehrlich P, Aldrink J, Rodeberg D, Baertschiger R. Central Venous Catheter Consideration in Pediatric Oncology: A Systematic Review and Meta-analysis From the American Pediatric Surgical Association Cancer Committee. Journal Of Pediatric Surgery 2024, 59: 1427-1443. PMID: 38637207, DOI: 10.1016/j.jpedsurg.2024.03.047.Peer-Reviewed Original ResearchCentral venous catheterIncreased risk of complicationsAbsolute neutrophil countRisk of complicationsIncreased riskCatheter placementCatheter compositionIncreased risk of hematomaTunneled central venous cathetersPlatelet count <Risk of hematomaMeta-analysisIncidence of complicationsLimited evidenceModern oncology practiceEnglish-language articlesCatheter salvageLock therapyNeutropenic patientsCatheter removalBloodstream infectionsTunneled cathetersPlatelet countNo significant differenceVenous cathetersMolecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules
Spaulding S, Maayah M, Dinauer C, Prasad M, Darbinyan A, Morotti R, Christison-Lagay E. Molecular Genetics Augment Cytopathologic Evaluation and Surgical Planning of Pediatric Thyroid Nodules. Journal Of Pediatric Surgery 2024, 59: 975-980. PMID: 38246817, DOI: 10.1016/j.jpedsurg.2024.01.001.Peer-Reviewed Original ResearchFine-needle aspiration biopsyPediatric thyroid nodulesMolecular genetic testingBethesda IV nodulesPrediction of malignancyDICER1 mutationsThyroid nodulesGenetic testingNRAS mutationsMethods Retrospective chart reviewRetrospective chart reviewTime of surgeryBRAF V600E testingMutations/fusionsBethesda III nodulesChart reviewSurgical resectionFinal histopathologyThyroid resectionPediatric dataHistologic classificationSurgical specimensBRAF mutationsAspiration biopsyCytopathologic evaluationAdolescents’ Perceptions of Screening, Brief Intervention, and Referral to Treatment Service at Pediatric Trauma Centers
Mello M, Baird J, Spirito A, Scott K, Zonfrillo M, Lee L, Kiragu A, Christison-Lagay E, Bromberg J, Ruest S, Pruitt C, Lawson K, Nasr I, Aidlen J, Maxson R, Becker S. Adolescents’ Perceptions of Screening, Brief Intervention, and Referral to Treatment Service at Pediatric Trauma Centers. Substance Use Research And Treatment 2024, 18: 29768357241272356. PMID: 39175910, PMCID: PMC11339738, DOI: 10.1177/29768357241272356.Peer-Reviewed Original ResearchPediatric trauma centerEHR dataSBIRT servicesTrauma centerBrief interventionPost-implementationReferral to treatment servicesPerceptions of screeningImplementation of SBIRTAdolescent self-report dataPre-implementation to post-implementationMedical record documentationReferral to treatmentMedical record dataSelf-reported dataPatients' medical recordsSBIRT implementationSpecialty careAOD screeningSpecialty servicesPre-implementationSBIRTRecord documentationSocial workAdolescents' perceptions
2023
Children's Oncology Group's 2023 blueprint for research: Surgery
Gow K, Lautz T, Malek M, Cost N, Newman E, Dasgupta R, Christison‐Lagay E, Tiao G, Davidoff A, Committee T. Children's Oncology Group's 2023 blueprint for research: Surgery. Pediatric Blood & Cancer 2023, 71: e30766. PMID: 37950538, PMCID: PMC10872730, DOI: 10.1002/pbc.30766.Peer-Reviewed Original ResearchCounseling for opioids prescribed at discharge of hospitalized adolescent trauma patients
Mello M, Lee L, Christison-Lagay E, Spirito A, Becker S, Bromberg J, Ruest S, Zonfrillo M, Scott K, Pruitt C, Lawson K, Nasr I, Aidlen J, Baird J. Counseling for opioids prescribed at discharge of hospitalized adolescent trauma patients. Injury Epidemiology 2023, 10: 53. PMID: 37872639, PMCID: PMC10594678, DOI: 10.1186/s40621-023-00465-2.Peer-Reviewed Original ResearchAdolescent trauma patientsElectronic health recordsTrauma patientsPain medicationHospital dischargeAdolescent patientsAOD useDocumentation of counselingPrescribed pain medicationPediatric trauma centerPrescription pain medicationOpioid use disorderScreening resultsSafe useHospital discussionPrescribed opioidsTrauma centerNational cohortSafety counselingOpioidsHigh riskPatientsUse disordersDrug useAdolescent SurveyCritical elements of pediatric neuroblastoma surgery
Shaffiey S, Le H, Christison-Lagay E, Fialkowski E, Aldrink J, Grant C, Honeyman J, Janek K, Madonna M, Rhee D, Nuchtern J, Newman E, LaQuaglia M, Davidoff A, Shamberger R, Malek M. Critical elements of pediatric neuroblastoma surgery. Seminars In Pediatric Surgery 2023, 32: 151338. PMID: 38042090, DOI: 10.1016/j.sempedsurg.2023.151338.Peer-Reviewed Original ResearchConceptsHigh-risk neuroblastomaOncology GroupChildren's Oncology GroupPediatric surgical oncologyLong-term survivalNeuroblastoma surgeryExtracranial malignanciesEffective surgeryPediatric oncologyChildhood cancerSurgical oncologyNeuroblastomaSurgeryInternational SocietyOncologyExpert opinionLiterature reviewPatientsMalignancyCancerIncidenceImportant role