2024
Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units
Shahu A, Namburar S, Banna S, Harris A, Schenck C, Trejo-Paredes C, Thomas A, Ali T, Carnicelli A, Barnett C, Solomon M, Miller P. Outcomes for Mechanically Ventilated Patients With Acute Myocardial Infarction Admitted to Medical vs Cardiac Intensive Care Units. JACC Advances 2024, 3: 101199. PMID: 39238851, PMCID: PMC11375252, DOI: 10.1016/j.jacadv.2024.101199.Peer-Reviewed Original ResearchAcute myocardial infarctionAssociated with lower in-hospital mortalityIn-hospital mortalityLower in-hospital mortalityIntensive care unitMedical ICUPrimary diagnosis of acute myocardial infarctionMultivariable adjustmentCICU admissionInvasive mechanical ventilationVizient Clinical Data BaseBackground Acute myocardial infarctionDiagnosis of acute myocardial infarctionMultivariate logistic regressionMedical intensive care unitClinical outcomesMechanical ventilationCardiogenic shockClinical Data BaseMyocardial infarctionHospital sizeTriage of critically ill patientsMedian ventilator daysTeaching hospitalLogistic regressionTracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure
Grammatico M, Banna S, Shahu A, Gastanadui M, Jimenez J, Heck C, Arias-Olson A, Thomas A, Ali T, Miller P. Tracheostomy in Patients with Acute Myocardial Infarction and Respiratory Failure. Journal Of Intensive Care Medicine 2024, 39: 1131-1137. PMID: 38715423, DOI: 10.1177/08850666241253202.Peer-Reviewed Original ResearchDays of tracheostomyInvasive mechanical ventilationIn-hospital mortalityAcute myocardial infarctionTiming of tracheostomyRespiratory failureAntiplatelet regimensMyocardial infarctionAssociated with lower in-hospital mortalityIncidence of tracheostomyLower in-hospital mortalityProportion of patientsIncidence of patientsDiagnosis of acute myocardial infarctionDAPT interruptionTracheostomy complicationsBlood transfusionOpen tracheostomyAntiplatelet therapyMechanical ventilationMultivariable adjustmentDAPT usePrimary diagnosis of acute myocardial infarctionClinical Data BaseTracheostomyComplex Heart–Lung Ventilator Emergencies in the CICU
Lopez M, Applefeld W, Miller P, Elliott A, Bennett C, Lee B, Barnett C, Solomon M, Corradi F, Sionis A, Mireles-Cabodevila E, Tavazzi G, Alviar C. Complex Heart–Lung Ventilator Emergencies in the CICU. Cardiology Clinics 2024, 42: 253-271. PMID: 38631793, DOI: 10.1016/j.ccl.2024.02.010.Peer-Reviewed Original ResearchPropofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction
Thomas A, Banna S, Shahu A, Ali T, Schenck C, Patel B, Notarianni A, Phommalinh M, Kochar A, Heck C, van Diepen S, Miller P. Propofol vs etomidate for induction prior to invasive mechanical ventilation in patients with acute myocardial infarction. American Heart Journal 2024, 272: 116-125. PMID: 38554762, DOI: 10.1016/j.ahj.2024.03.013.Peer-Reviewed Original ResearchConceptsAssociated with lower mortalityAcute myocardial infarctionInvasive mechanical ventilationLower mortalityUS national databaseClinical Data BaseMyocardial infarctionIll patient populationLength of stayCritically ill patient populationIn-hospital mortalityInverse probability treatmentOptimal induction agentInduction agentNational databaseClinical outcomesMechanical ventilationProbability treatmentPropensity weightingPatient populationRandomized trialsMortalityUtilization of propofolVentilator daysPropofol group
2023
Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction
Banna S, Schenck C, Shahu A, Thomas A, Heck C, Tangredi R, Ali T, Miller P. Stress Ulcer Prophylaxis in Mechanically Ventilated Patients With Acute Myocardial Infarction. JACC Advances 2023, 3: 100750. PMID: 38939822, PMCID: PMC11198220, DOI: 10.1016/j.jacadv.2023.100750.Peer-Reviewed Original ResearchInvasive mechanical ventilationProton pump inhibitorsStress ulcer prophylaxisAcute myocardial infarctionUlcer prophylaxisVentilator-associated pneumoniaMyocardial infarctionVentilator daysST-segment elevation myocardial infarctionBackground Proton pump inhibitorsLess ventilator-associated pneumoniaVizient Clinical Data BaseObservation cohort studyProportion of patientsElevation myocardial infarctionMultivariable logistic regressionClostridium difficile infectionLower hospitalization costsClinical data baseCardiogenic shockHospital mortalityCohort studyMultivariate adjustmentHospitalization costsMechanical ventilationRocuronium Versus Succinylcholine in Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation
Schenck C, Banna S, Heck C, Ali T, Miller P. Rocuronium Versus Succinylcholine in Patients With Acute Myocardial Infarction Requiring Mechanical Ventilation. Journal Of The American Heart Association 2023, 12: e8468. PMID: 37158165, PMCID: PMC10227322, DOI: 10.1161/jaha.123.029775.Peer-Reviewed Original ResearchLiberation From Mechanical Ventilation in the Cardiac Intensive Care Unit
Shahu A, Banna S, Applefeld W, Rampersad P, Alviar C, Ali T, Luk A, Fajardo E, van Diepen S, Miller P. Liberation From Mechanical Ventilation in the Cardiac Intensive Care Unit. JACC Advances 2023, 2: 100173. PMID: 38939038, PMCID: PMC11198553, DOI: 10.1016/j.jacadv.2022.100173.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsContemporary cardiac intensive care unitsInvasive mechanical ventilationCardiac intensive care unitIntensive care unitCare unitMechanical ventilationPost-extubation careSpontaneous breathing trialCareful clinical assessmentPositive pressure ventilationExtubation failureRespiratory decompensationSedation managementBreathing trialRespiratory failurePressure ventilationVentilator weaningExtubation readinessCardiovascular patientsClinical assessmentCardiopulmonary interactionsHigh riskPatientsVentilationSignificant increase
2021
Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes
Miller PE, Mullan CW, Chouairi F, Sen S, Clark KA, Reinhardt S, Fuery M, Anwer M, Geirsson A, Formica R, Rogers JG, Desai NR, Ahmad T. Mechanical ventilation at the time of heart transplantation and associations with clinical outcomes. European Heart Journal Acute Cardiovascular Care 2021, 10: 843-851. PMID: 34389855, PMCID: PMC8557439, DOI: 10.1093/ehjacc/zuab063.Peer-Reviewed Original ResearchConceptsHeart transplantationMechanical ventilationSingle-organ heart transplantationMedian waitlist timeOrgan Sharing databaseTime of transplantationMultivariable logistic regressionMultivariable adjustmentWaitlist timeClinical outcomesSharing databasePoor outcomeVentilated patientsUnited NetworkTemporary mechanical supportClinical acuityTransplantationPatientsPrevious dialysisLogistic regressionMortalityStrong associationReasonable outcomesOutcomesAssociationThe association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality
Nandiwada S, Islam S, Jentzer JC, Miller PE, Fordyce CB, Lawler P, Alviar CL, Sun LY, Dover DC, Lopes RD, Kaul P, van Diepen S. The association between cardiac intensive care unit mechanical ventilation volumes and in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: 797-805. PMID: 34318875, PMCID: PMC9067446, DOI: 10.1093/ehjacc/zuab055.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitMechanical ventilationHospital mortalityRespiratory failureCICU LOSNon-invasive mechanical ventilationNational population-based dataInvasive mechanical ventilationVolume-mortality relationshipProlonged mechanical ventilationProportion of patientsHigh-volume hospitalsPercutaneous coronary interventionLow-volume centersHigh-volume centersIntensive care unitPopulation-based dataOutcomes of interestCICU lengthCICU admissionCoronary interventionSurgical ICUCare unitVolume centersLower incidenceHigher CICU mechanical ventilation volumes are associated with lower in-hospital mortality
Nandiwada S, Islam S, Jentzer J, Miller P, Fordyce C, Lawler P, Alviar C, Sun L, Dover D, Kaul P, Van Diepen S. Higher CICU mechanical ventilation volumes are associated with lower in-hospital mortality. European Heart Journal Acute Cardiovascular Care 2021, 10: zuab020.161. DOI: 10.1093/ehjacc/zuab020.161.Peer-Reviewed Original ResearchCardiac intensive care unitCICU LOSIn-hospital mortalityAssociated with lower in-hospital mortalityProlonged MVLower in-hospital mortalityProportion of patientsMechanical ventilationRespiratory failureVolume centersCardiac intensive care unit lengthCardiac intensive care unit admissionIncidence of respiratory failureNon-invasive mechanical ventilationAssociated with reduced mortalityInvasive mechanical ventilationLow-volume centersIntensive care unitHigh-volume hospitalsCardiac intensive care unit populationPopulation-based dataSurgical ICUOdds ratioAcademic centersCare unitAssociation between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials
Miller PE, Van Diepen S, Metkus TS, Alviar CL, Rayner-Hartley E, Rathwell S, Katz JN, Ezekowitz J, Desai NR, Ahmad T. Association between Respiratory Failure and Clinical Outcomes in Patients with Acute Heart Failure: Analysis of 5 Pooled Clinical Trials. Journal Of Cardiac Failure 2021, 27: 602-606. PMID: 33556546, PMCID: PMC8527461, DOI: 10.1016/j.cardfail.2021.01.018.Peer-Reviewed Original ResearchConceptsAcute heart failureBaseline ejection fractionMechanical ventilationRespiratory failureHeart failureClinical trialsClinical outcomesHF etiologyHF rehospitalizationEjection fractionAcute HF admissionBaseline diabetes mellitusHF clinical trialsMechanical ventilation groupMechanical ventilation useProportion of patientsChronic lung diseaseMultivariable logistic regressionOriginal clinical trialsCause mortalityHF admissionsIndex hospitalizationMultivariable adjustmentSmoking historyVentilation group
2020
Advanced Respiratory Support in the Contemporary Cardiac ICU
Metkus TS, Miller PE, Alviar CL, Baird-Zars VM, Bohula EA, Cremer PC, Gerber DA, Jentzer JC, Keeley EC, Kontos MC, Menon V, Park JG, Roswell RO, Schulman SP, Solomon MA, van Diepen S, Katz JN, Morrow DA. Advanced Respiratory Support in the Contemporary Cardiac ICU. Critical Care Explorations 2020, 2: e0182. PMID: 33235999, PMCID: PMC7678799, DOI: 10.1097/cce.0000000000000182.Peer-Reviewed Original ResearchHigh-flow nasal cannulaAdvanced respiratory supportCardiac ICU admissionInvasive mechanical ventilationCardiac ICURespiratory supportICU admissionNoninvasive ventilationNasal cannulaMechanical ventilationHospital mortalityCritical Care Cardiology Trials NetworkChronic obstructive pulmonary diseaseAdvanced respiratory therapiesCardiac ICU patientsPrimary cardiac problemsProspective cohort studyPulmonary vascular diseaseObstructive pulmonary diseaseCritical care needsGeneral medical problemsCritical care trainingNoncardiac diagnosesReintubation rateAdmission diagnosisOutcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial
Giménez M, Miller PE, Alviar CL, van Diepen S, Granger CB, Montalescot G, Windecker S, Maier L, Serpytis P, Serpytis R, Oldroyd KG, Noc M, Fuernau G, Huber K, Sandri M, de Waha-Thiele S, Schneider S, Ouarrak T, Zeymer U, Desch S, Thiele H. Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial. Journal Of Clinical Medicine 2020, 9: 860. PMID: 32245139, PMCID: PMC7141492, DOI: 10.3390/jcm9030860.Peer-Reviewed Original ResearchAcute myocardial infractionCULPRIT-SHOCK trialCardiogenic shockMechanical ventilationHigh-risk populationClinical outcomesMultivessel coronary artery diseaseSpecific high-risk populationsTriple vessel diseaseCoronary artery diseaseAcute myocardial infarctionFirst dayElevated heart rateHigher body weightMV initiationRandomized patientsRespiratory failureArtery diseaseVessel diseaseAdverse outcomesMyocardial infarctionRisk factorsOutcomes AssociatedHeart rateHigh risk
2019
National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support
Miller PE, Patel S, Saha A, Guha A, Pawar S, Poojary P, Ratnani P, Chan L, Kamholz SL, Alviar CL, van Diepen S, Nasir K, Ahmad T, Nadkarni GN, Desai NR. National Trends in Incidence and Outcomes of Patients With Heart Failure Requiring Respiratory Support. The American Journal Of Cardiology 2019, 124: 1712-1719. PMID: 31585698, DOI: 10.1016/j.amjcard.2019.08.033.Peer-Reviewed Original ResearchConceptsInvasive mechanical ventilationUse of NIVRespiratory support strategiesNoninvasive ventilationHeart failureHospital mortalityRespiratory supportOutcomes of patientsNational Inpatient SampleLength of stayHF hospitalizationIMV groupHF patientsNIV groupRespiratory failureMechanical ventilationHospital chargesInpatient SamplePrimary diagnosisHospital costsMedical complexityPatientsSupport strategiesStudy periodMortality