2023
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Martin-Lopez E, Vidyadhara D, Liberia T, Meller S, Harmon L, Hsu R, Spence N, Brennan B, Han K, Yücel B, Chandra S, Greer C. α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease. Journal Of Neuroscience 2023, 43: 1051-1071. PMID: 36596700, PMCID: PMC9908323, DOI: 10.1523/jneurosci.1526-22.2022.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-SynucleinAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicNeurogenesisOlfaction DisordersParkinson DiseaseProteomicsSmellConceptsΑ-syn tg miceΑ-Syn pathologyOlfactory bulb neurogenesisProjection neuronsParkinson's diseaseOlfactory dysfunctionMutant α-synucleinOlfactory deficitsOlfactory pathwaySyn pathologyBehavioral deficitsMouse modelΑ-synucleinOB granule cellsΑ-synuclein pathologyOlfactory systemMonths of ageReduced neurogenesisFunctional deficitsPeriglomerular cellsMotor progressionPathologic changesMultiple symptomsSynaptic terminalsGranule cells
2013
Clonal Astrocytic Response to Cortical Injury
Martín-López E, García-Marques J, Núñez-Llaves R, López-Mascaraque L. Clonal Astrocytic Response to Cortical Injury. PLOS ONE 2013, 8: e74039. PMID: 24040158, PMCID: PMC3769363, DOI: 10.1371/journal.pone.0074039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBiomarkersBrain InjuriesCell ProliferationCerebral CortexClone CellsDisease Models, AnimalElectroporationHypertrophyMiceConceptsDays post injuryHigher proliferative responsesCentral nervous systemCortical injuryStrong morphological alterationsAstrocytic responsePost injuryBrain injuryGlial functionGlial cellsProliferative responseImmunohistochemical analysisNervous systemAstrocyte heterogeneitySame cloneInjuryMechanical injuryAstrocytesMorphological alterationsClonal responseHeterogeneous populationDistinct clonesCell lineagesMorphological changesMultifaceted role