2021
Inflammatory hydrocephalus
Robert SM, Reeves BC, Marlier A, Duy PQ, DeSpenza T, Kundishora A, Kiziltug E, Singh A, Allington G, Alper SL, Kahle KT. Inflammatory hydrocephalus. Child's Nervous System 2021, 37: 3341-3353. PMID: 34164718, DOI: 10.1007/s00381-021-05255-z.Peer-Reviewed Original ResearchConceptsPost-infectious hydrocephalusImmune cell profilesCerebrospinal fluid diversion techniquesPotential therapeutic vulnerabilitiesImportant protective responseCSF cytokinesProlong diseaseSustained inflammationHigher complicationsPreventable conditionClinical studiesNeurosurgical disordersReparative inflammationDistinct etiologiesHuman patientsHydrocephalusCell profilesProtective responseTherapeutic vulnerabilitiesPhysical irritantsCommon formInflammationDiversion techniquesDisordersFailure rate
2020
Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets
Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nature Reviews Neurology 2020, 16: 285-296. PMID: 32152460, PMCID: PMC7375440, DOI: 10.1038/s41582-020-0321-y.Peer-Reviewed Original ResearchConceptsPosthaemorrhagic hydrocephalusPostinfectious hydrocephalusNeurosurgical disordersPathogenic mechanismsToll-like receptor 4Pathogenesis of hydrocephalusImportant protective responseEpendymal denudationCommon neurosurgical disorderSustained inflammationInflammatory mediatorsNeuroinflammatory conditionsImmune cellsReceptor 4Therapeutic approachesReparative inflammationCerebrospinal fluidCSF pathwaysHydrocephalusTherapeutic targetInflammationTherapeutic interventionsBrain ventriclesProtective responsePhysical irritants