2024
Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder.
Mehta S, Peterson H, Ye J, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Yip S, Hahn C, Lacadie C, Greene A, Jeon S, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D, Weintraub E. Alterations in Volume and Intrinsic Resting-State Functional Connectivity Detected at Brain MRI in Individuals with Opioid Use Disorder. Radiology 2024, 313: e240514. PMID: 39656127, DOI: 10.1148/radiol.240514.Peer-Reviewed Original ResearchConceptsHealthy control participantsRight medial temporal lobeOpioid use disorderFunctional brain alterationsMedial temporal lobeOpioid use disorder groupFunctional connectivityUse disorderControl participantsBrain alterationsIntrinsic resting-state functional connectivityTemporal lobeMedial prefrontal cortex volumesVoxel-wise linear regressionT1-weighted MRIResting-state functional connectivityFamily-wise error correctionPrefrontal cortex volumeResting-state functional MRIIncreased functional connectivityIntrinsic connectivity distributionFunctional MRI studiesFemale participantsRegional brain volumesAssess group differences
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratio
2017
Connectome-based Models Predict Separable Components of Attention in Novel Individuals
Rosenberg MD, Hsu WT, Scheinost D, Constable R, Chun MM. Connectome-based Models Predict Separable Components of Attention in Novel Individuals. Journal Of Cognitive Neuroscience 2017, 30: 160-173. PMID: 29040013, DOI: 10.1162/jocn_a_01197.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingAttention Network TaskExecutive controlIntrinsic functional organizationRT variabilityANT performanceInfluential modelFunctional connectivityBrain's intrinsic functional organizationComponents of attentionExecutive control scoresResting-state functional connectivityResting-state dataFunctional brain networksFunctional organizationTask-based dataAttentional abilitiesUpcoming stimulusExplicit taskSustained attentionFMRI scanningAttention factorNovel individualsAdditional independent componentNetwork tasks
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAge
2013
Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks