2023
Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States
Ye J, Sun H, Gao S, Dadashkarimi J, Rosenblatt M, Rodriguez R, Mehta S, Jiang R, Noble S, Westwater M, Scheinost D. Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States. Biological Psychiatry 2023, 94: 580-590. PMID: 37031780, PMCID: PMC10524212, DOI: 10.1016/j.biopsych.2023.03.024.Peer-Reviewed Original ResearchConceptsAberrant brain dynamicsMultiple brain statesBipolar disorderTask-based functional magnetic resonanceFunctional magnetic resonanceAltered brain dynamicsBrain statesTask-based functional magnetic resonance imagingFunctional magnetic resonance imagingMagnetic resonance imagingHealthy control participantsBrain dynamicsSignificant group differencesMagnetic resonanceMultivariate analysisResonance imagingSchizophreniaTime pointsControl participantsGroup differencesNeural mechanismsOlder participantsPreliminary evidenceDynamic alterationsDisorders
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry
2018
Craving to Quit: A Randomized Controlled Trial of Smartphone App–Based Mindfulness Training for Smoking Cessation
Garrison KA, Pal P, O’Malley S, Pittman BP, Gueorguieva R, Rojiani R, Scheinost D, Dallery J, Brewer JA. Craving to Quit: A Randomized Controlled Trial of Smartphone App–Based Mindfulness Training for Smoking Cessation. Nicotine & Tobacco Research 2018, 22: 324-331. PMID: 29917096, PMCID: PMC7297096, DOI: 10.1093/ntr/nty126.Peer-Reviewed Original ResearchConceptsMindfulness trainingExperience samplingPreliminary evidenceSmartphone appPoint prevalence abstinence ratesMindfulnessSmoking cessationTreatment startersSmoking ratesGroup differencesGroup interactionCravingStrong positive associationAbstinence ratesTrainingTreatment completionPositive associationControlled TrialsTreat approachSmokingTrialsCigarettesMonthsAppsAssociation