2009
Baseline brain energy supports the state of consciousness
Shulman RG, Hyder F, Rothman DL. Baseline brain energy supports the state of consciousness. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11096-11101. PMID: 19549837, PMCID: PMC2708743, DOI: 10.1073/pnas.0903941106.Peer-Reviewed Original ResearchConceptsLoss of consciousnessBrain energyConscious stateHigh-frequency neuronal activityCerebral energy consumptionBrain energy consumptionCerebral energyEnsembles of neuronsRat brainSomatosensory responsesNeuronal activityGamma-band rangeNeuronal propertiesFiring rateSensory stimulationNeuronal signalingPET measurementsAnesthesiaFMRI patternsFMRI activity patternsOxygen consumptionState of consciousnessStimulationBehavioral abilitiesMagnetic resonance spectroscopy
2001
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Patel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.Peer-Reviewed Original Research
1999
New Approaches to Functional Neuroenergetics
Fitzpatrick S, Rothman D. New Approaches to Functional Neuroenergetics. Journal Of Cognitive Neuroscience 1999, 11: 467-471. PMID: 10507889, DOI: 10.1162/089892999563454.Peer-Reviewed Original ResearchEnergy on demand.
Magistretti P, Pellerin L, Rothman D, Shulman R. Energy on demand. Science 1999, 283: 496-7. PMID: 9988650, DOI: 10.1126/science.283.5401.496.Peer-Reviewed Original Research
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo resultsInterpreting functional imaging studies in terms of neurotransmitter cycling
Shulman R, Rothman D. Interpreting functional imaging studies in terms of neurotransmitter cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11993-11998. PMID: 9751778, PMCID: PMC21753, DOI: 10.1073/pnas.95.20.11993.Peer-Reviewed Original ResearchConceptsFunctional imaging experimentsNeurobiological processesFunctional magnetic resonance imagingBasis of neuroscienceSpecific mental processesFunctional imaging studiesFunctional imaging dataVivo 13C NMR measurementsCognitive psychologyCognitive tasksMental processesPsychological termsPsychological interpretationImaging experimentsNeuroscientific interpretationSensory stimulationPsychological designHuman brainFunctional imaging signalsNeurotransmitter cyclingParticular positron emission tomographyNeurotransmitter fluxBrain energy consumptionImaging studiesImaging data
1993
NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia
Hossmann K, Behar K, Rothman D. NMR-Spectroscopic Investigation of Cerebral Reanimation After Prolonged Ischemia. Acta Neurochirurgica Supplement 1993, 57: 21-29. PMID: 8421952, DOI: 10.1007/978-3-7091-9266-5_3.Peer-Reviewed Original ResearchConceptsHour complete ischemiaResidual blood flowBlood flowComplete ischemiaBrain injuryComplete recoveryBrain energy stateIrreversible brain injuryDuration of ischemiaAppropriate therapeutic measuresRise of lactatePost-ischemic injuryN-acetyl aspartateNon-invasive assessmentBrain glucose contentDepth of anesthesiaLower metabolite levelsBlood reperfusionIschemia timeReflow phenomenonBrain metabolismContinuous non-invasive assessmentProlonged ischemiaTherapeutic measuresIschemia
1991
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 5829-5831. PMID: 2062861, PMCID: PMC51971, DOI: 10.1073/pnas.88.13.5829.Peer-Reviewed Original ResearchMeSH KeywordsEnergy MetabolismHumansLactatesMagnetic Resonance SpectroscopyVision, OcularVisual CortexVisual Perception
1989
NMR Spectroscopic Investigation of the Recovery of Energy and Acid—Base Homeostasis in the Cat Brain after Prolonged Ischemia
Behar K, Rothman D, Hossmann K. NMR Spectroscopic Investigation of the Recovery of Energy and Acid—Base Homeostasis in the Cat Brain after Prolonged Ischemia. Cerebrovascular And Brain Metabolism Reviews 1989, 9: 655-665. PMID: 2777935, DOI: 10.1038/jcbfm.1989.93.Peer-Reviewed Original Research