2001
Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After Stroke
Graham G, Hwang J, Rothman D, Prichard J. Spectroscopic Assessment of Alterations in Macromolecule and Small-Molecule Metabolites in Human Brain After Stroke. Stroke 2001, 32: 2797-2802. PMID: 11739976, DOI: 10.1161/hs1201.099414.Peer-Reviewed Original Research
2000
Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis
Pan J, Rothman D, Behar K, Stein D, Hetherington H. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 1502-1507. PMID: 11043913, DOI: 10.1097/00004647-200010000-00012.Peer-Reviewed Original ResearchConceptsBHB levelsPlasma BHB levelsField magnetic resonance spectroscopyHigh-field magnetic resonance spectroscopyBrain lactateKetogenic dietCalcarine fissureNonfasted stateOccipital lobeHealthy adultsLactate increaseThird dayΒ-hydroxybutyrateKetosisBHB concentrationsBrainBHBGlucose phosphorylationLactate oxidationMagnetic resonance spectroscopy
1998
In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse train
Shen J, Novotny E, Rothman D. In vivo lactate and β‐hydroxybutyrate editing using a pure‐phase refocusing pulse train. Magnetic Resonance In Medicine 1998, 40: 783-788. PMID: 9797163, DOI: 10.1002/mrm.1910400520.Peer-Reviewed Original Research
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
Analysis of macromolecule resonances in 1H NMR spectra of human brain
Behar K, Rothman D, Spencer D, Petroff O. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance In Medicine 1994, 32: 294-302. PMID: 7984061, DOI: 10.1002/mrm.1910320304.Peer-Reviewed Original ResearchProton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS
Blamire A, Graham G, Rothman D, Prichard J. Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS. Magnetic Resonance Imaging 1994, 12: 1227-1235. PMID: 7854028, DOI: 10.1016/0730-725x(94)90087-8.Peer-Reviewed Original ResearchConceptsStroke patientsAge-matched normal subjectsHuman strokeSpin-echo MRINormal subjectsNormal brainPatientsInfarcted tissueProton T2 relaxation timesInverse correlationHigh inverse correlationT2 relaxation timesCholine resonanceSignificant differencesProton spectroscopyPercentage volumeT2 valuesT. SpectraPartial volume effectsPeak amplitudeSTEAM sequence
1988
Spatially localized 1H NMR spectra of metabolites in the human brain.
Hanstock C, Rothman D, Prichard J, Jue T, Shulman R. Spatially localized 1H NMR spectra of metabolites in the human brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 1821-1825. PMID: 3162309, PMCID: PMC279871, DOI: 10.1073/pnas.85.6.1821.Peer-Reviewed Original Research
1985
1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Hollander J, Bendall M, Petroff O, Shulman R. 1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 1633-1637. PMID: 2858850, PMCID: PMC397326, DOI: 10.1073/pnas.82.6.1633.Peer-Reviewed Original Research
1984
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.
Rothman D, Behar K, Hetherington H, Shulman R. Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 6330-6334. PMID: 6149543, PMCID: PMC391917, DOI: 10.1073/pnas.81.20.6330.Peer-Reviewed Original ResearchDetection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
Behar K, Rothman D, Shulman R, Petroff O, Prichard J. Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T). Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 2517-2519. PMID: 6585812, PMCID: PMC345093, DOI: 10.1073/pnas.81.8.2517.Peer-Reviewed Original Research