2020
Early access to antiretroviral therapy versus standard of care among HIV‐positive participants in Eswatini in the public health sector: the MaxART stepped‐wedge randomized controlled trial
Khan S, Spiegelman D, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Chao A, Bärnighausen T, Okello V. Early access to antiretroviral therapy versus standard of care among HIV‐positive participants in Eswatini in the public health sector: the MaxART stepped‐wedge randomized controlled trial. Journal Of The International AIDS Society 2020, 23: e25610. PMID: 32949103, PMCID: PMC7507004, DOI: 10.1002/jia2.25610.Peer-Reviewed Original ResearchConceptsViral suppressionStandard of careAntiretroviral treatmentCox proportional hazards modelHealth systemART-naïve participantsHIV-positive patientsHIV-positive adultsViral load monitoringHIV-positive participantsAppropriate care managementProportional hazards modelEarly accessPublic sector health facilitiesHealth system effectsPublic health systemHealth system's abilityClinic transitionAntiretroviral therapyCD4 countCare retentionVL monitoringPublic health sectorDisease stageEndpoint rateUniversal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini
Boeke C, Khan S, Walsh F, Hettema A, Lejeune C, Spiegelman D, Okello V, Harwell J, Mazibuko S, Bärnighausen T. Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini. HIV Medicine 2020, 22: 54-59. PMID: 32876360, DOI: 10.1111/hiv.12941.Peer-Reviewed Original ResearchConceptsBody mass indexStepped-wedge trialDisease progressionCD4 countSevere diseaseMultivariate Cox proportional hazards modelWorld Health Organization stageCox proportional hazards modelHIV disease progressionMorbidity/mortalityCells/Proportional hazards modelLower ratesIncident tuberculosisCD4 declineMass indexUniversal testHealth facilitiesBaseline valuesHazards modelHealth outcomesCrowded hospitalsWeight lossProgressionHIV
2010
Maternal Vitamin D Status and Child Tuberculosis, Anemia, and Morbidity in Tanzania
Finkelstein J, Mehta S, Manji K, Duggan C, Mugusi F, Spiegelman D, Msamanga G, Fawzi W. Maternal Vitamin D Status and Child Tuberculosis, Anemia, and Morbidity in Tanzania. The FASEB Journal 2010, 24: 227.3-227.3. DOI: 10.1096/fasebj.24.1_supplement.227.3.Peer-Reviewed Original ResearchMaternal vitamin D statusVitamin D statusLow vitamin D statusD statusLow vitamin D levelsPregnant Tanzanian womenTrial of vitaminVitamin D levelsChild health outcomesAssociation of outcomesTimes greater riskProportional hazards modelMonths of ageCD4 countHIV stageChart reviewPulmonary tuberculosisRespiratory symptomsChild tuberculosisSevere anemiaD levelsLowest quintileSecond quintileAnemia outcomesLower risk
2002
Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection
Wilson I, Jacobson D, Roubenoff R, Spiegelman D, Knox T, Gorbach S. Changes in lean body mass and total body weight are weakly associated with physical functioning in patients with HIV infection. HIV Medicine 2002, 3: 263-270. PMID: 12444944, DOI: 10.1046/j.1468-1293.2002.00122.x.Peer-Reviewed Original ResearchConceptsTotal body weightSelf-reported physical functioningPhysical functioningHIV infectionBody weightRelationship of changesCells/ micro l.Mean CD4 countHIV-positive personsMain outcome measuresLean body massLongitudinal analysisCD4 countCohort studyPositive personsOutcome measuresHealthy personsBody compositionPatientsStudy designWeight lossMicro l.InfectionWomenHealthy living
2001
Weight and body composition in a cohort of HIV-positive men and women
Forrester J, Spiegelman D, Woods M, Knox T, Fauntleroy J, Gorbach S. Weight and body composition in a cohort of HIV-positive men and women. Public Health Nutrition 2001, 4: 743-747. PMID: 11415480, DOI: 10.1079/phn200099.Peer-Reviewed Original Research
2000
Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection
Missmer S, Spiegelman D, Gorbach S, Miller T. Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection. Pediatrics 2000, 106: e24-e24. PMID: 10920180, DOI: 10.1542/peds.106.2.e24.Peer-Reviewed Original ResearchConceptsHeight z-scoreHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionTotal health scoreFunctional statusHealth scoresZ-scoreGeneral healthVirus infectionBaseline evaluationCD4 T-lymphocyte countFunctional status parametersFunctional status surveyHIV disease stageT-lymphocyte countsAbsolute CD4 countGeneral health scoresImportant clinical predictorsSignificant univariate predictorsFunctional status scoresMain outcome measuresNon-white raceResponsiveness scoresPredictors of changeCD4 countRelation of lean body mass to health-related quality of life in persons with HIV.
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of lean body mass to health-related quality of life in persons with HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-46. PMID: 10935689, DOI: 10.1097/00126334-200006010-00008.Peer-Reviewed Original ResearchConceptsGeneral health perceptionPhysical functionHealth-related qualityLean body massHigher lean body massHealth perceptionAssociated with better physical functionClinical impact of interventionsHealth-related quality of lifeDiverse population of personsBioimpedance analysisPatient self-reportBody massImpact of interventionsPopulation of personsCross-sectional analysisQuality of lifeIncreased LBMSelf-reportDiverse populationsEnergy/fatigueMultivariate modelHIVCD4 countHIV infectionRelation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-146. DOI: 10.1097/00042560-200006010-00008.Peer-Reviewed Original ResearchConceptsLean body massHigher lean body massGeneral health perceptionEnergy/fatiguePhysical functioningHealth perceptionBetter general health perceptionBioimpedance analysisDesign Cross-sectional analysisMeasures of HRQLHealth-related qualityBody massLast monthBetter physical functioningQuality of lifeCross-sectional analysisCD4 countHIV infectionMean ageClinical impactMultivariable modelHIVCells/Number of daysWomenRelation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV
Wilson I, Roubenoff R, Knox T, Spiegelman D, Gorbach S. Relation of Lean Body Mass to Health-Related Quality of Life in Persons With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 137-146. DOI: 10.1097/00126334-200006010-00007.Peer-Reviewed Original ResearchLean body massHigher lean body massGeneral health perceptionEnergy/fatiguePhysical functioningHealth perceptionBetter general health perceptionBioimpedance analysisMeasures of HRQLHealth-related qualityBody massLast monthBetter physical functioningQuality of lifeCross-sectional analysisCD4 countHIV infectionMean ageClinical impactMultivariable modelHIVCells/Number of daysWomenMen