2019
Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
Djureinovic D, Pontén V, Landelius P, Al Sayegh S, Kappert K, Kamali-Moghaddam M, Micke P, Ståhle E. Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung. BMC Cancer 2019, 19: 741. PMID: 31357969, PMCID: PMC6664554, DOI: 10.1186/s12885-019-5943-3.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma of LungAgedBlood ProteinsCarcinoembryonic AntigenCarcinoma, Non-Small-Cell LungChemokines, CXCCohort StudiesData AccuracyEarly Detection of CancerFemaleGPI-Linked ProteinsHumansImmunoassayLung NeoplasmsMaleMass ScreeningModels, BiologicalReceptor, ErbB-3ROC CurveSensitivity and SpecificityStatistics, NonparametricVascular Endothelial Growth Factor Receptor-2ConceptsNon-small cell lung cancerProximity extension assayLung adenocarcinomaLung diseaseDisease groupNon-malignant lung diseasesEarly lung cancer detectionCell lung cancerDifferent lung diseasesDifferent plasma levelsMultiplex proximity extension assayHigh clinical relevanceNovel protein markersDifferent plasma concentrationsLocalized diseaseOverall prognosisSurgical resectionNSCLC patientsLung metastasesColorectal cancerLung cancerPlasma levelsTypical carcinoidLung conditionsLAC patients
2013
A systematic analysis of commonly used antibodies in cancer diagnostics
Gremel G, Bergman J, Djureinovic D, Edqvist P, Maindad V, Bharambe B, Khan W, Navani S, Elebro J, Jirström K, Hellberg D, Uhlén M, Micke P, Pontén F. A systematic analysis of commonly used antibodies in cancer diagnostics. Histopathology 2013, 64: 293-305. PMID: 24330150, DOI: 10.1111/his.12255.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesBiomarkers, TumorHumansImmunohistochemistryNeoplasmsSensitivity and SpecificityConceptsDifferential diagnosticsCancer typesBenefit of immunohistochemistryTissue microarray cohortProstate-specific antigenEvidence-based dataCombination of antibodiesNumber of antibodiesMicroarray cohortMetastatic lesionsPrimary tumorClinical ImmunohistochemistryNovel markerImmunohistochemistryTumor samplesAntibodiesTumorsDiagnostic powerConsecutive sectionsDiagnostic antibodiesDifferent organsPresent studyPivotal roleCancer diagnosticsOptimal use