Denise Esserman, PhD
Professor of BiostatisticsCards
Contact Info
About
Titles
Professor of Biostatistics
Biography
Denise Esserman joined the Yale School of Public Health faculty in 2014 as an associate professor of biostatistics. She is interested in methods related to clustered randomized trials and the impact of the ICC and other factors on calculating sample size. As a member of the Yale Center for Analytical Sciences, she collaborates with a number of departments at the Yale School of Medicine, including the Clinical and Translational Science Award Program, Patient-Centered Outcomes Research Institute, and the Cancer Center. She has reviewed articles for the American Journal of Epidemiology, Arteriosclerosis, Thrombosis and Vascular Biology; Statistics in Biopharmaceutical Research; Clinical Trials; and Obesity. Esserman earned her doctorate at Columbia University and has since taught at the University of North Carolina, Chapel Hill.
Appointments
Biostatistics
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Columbia University (2006)
- MS
- University of Georgia (2001)
Research
Overview
Medical Research Interests
ORCID
0000-0003-1326-9618
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Michael Kane, PhD, MA, MS
Erich J Greene, PhD
Fan Li, PhD
David Ganz
Frederick Lewis Altice, MD, MA
Leah Ferrucci, PhD, MPH
Longitudinal Studies
Publications
2025
Randomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol
Pachankis J, Chiaramonte D, Scheer J, Ankrum H, Eisenstadt B, Hobbs R, Baldwin H, Kidd J, Witkiewitz K, Esserman D, Plourde K, Drabble L, Hughes T. Randomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol. BMJ Open 2025, 15: e086738. PMID: 40032395, PMCID: PMC11877267, DOI: 10.1136/bmjopen-2024-086738.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCognitive-behavioral therapy interventionSexual minority womenMinority womenHazardous drinkingMinority stressRandomised controlled trialsProportion of heavy drinking daysSessions of supportive counselingComorbid mental health problemsRisk of hazardous drinkingCognitive-behavioral therapyHeavy drinking daysHazardous alcohol useHuman Subjects CommitteeMental health comorbiditiesMental health problemsAnxiety disordersAnxious symptomsDrinking daysEvidence-based interventionsSupportive counselingControlled trialsStress copingComorbid depression/anxietyDisproportionate riskEndpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention
Ganz D, Greene E, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Esserman D. Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention. Journal Of Clinical Epidemiology 2025, 181: 111718. PMID: 39938700, DOI: 10.1016/j.jclinepi.2025.111718.Peer-Reviewed Original ResearchConceptsRatio of hazard ratiosHazard ratioConfidence intervalsDevelop Confidence in EldersEnhanced usual careFall injury riskPrimary care practicesFall injury preventionPrimary outcomeIncreasing length of follow-upCluster randomized trialUS healthcare systemStudy dataEstimates of validityUsual careInjury preventionCare practicesMultifactorial interventionOutcome ascertainmentInjury riskCluster-randomizedCare managementRandomized controlled trial dataStride dataHealthcare system
2024
Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine
Machavariani E, Bromberg D, Dumchev K, Esserman D, Earnshaw V, Pykalo I, Filippovich M, Ivasiy R, Ahmad B, Long J, Haddad M, Madden L, Oliveros D, Dvoriak S, Altice F. Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine. International Journal Of Drug Policy 2024, 136: 104682. PMID: 39705875, PMCID: PMC11821433, DOI: 10.1016/j.drugpo.2024.104682.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPrimary care centersQuality health indicatorsProvider stigmaEvidence-based practiceGuideline-concordantPatient outcomesHealth indicatorsReduce provider stigmaCare centerInfluence healthcare utilizationSpecialty health servicesPatient-level outcomesTele-educationImprove patient outcomesProvider fearsImplementation trialHealthcare utilizationPreventive careHealth servicesPoor healthLinear mixed-effects modelsImprove attitudesStigmaIncrease accessMixed-effects modelsBayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrainDesign and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine
Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden L, Bromberg D, Haddad M, Morozova O, Ahmad B, Gómez D, Farnum S, Dvoriak S, Altice F. Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine. Contemporary Clinical Trials 2024, 146: 107690. PMID: 39265780, PMCID: PMC11531372, DOI: 10.1016/j.cct.2024.107690.Peer-Reviewed Original ResearchConceptsPrimary care centersQuality health indicatorsNon-communicable diseasesSpecialty treatment centersOpioid agonist therapyImplementation of integrated carePay-for-performance incentivesPrimary care clinicsPrimary care settingSelf-reported prevalencePay-for-performancePrevalence of medical comorbiditiesParticipants self-reportedEffective evidence-based treatmentsHealth of PWIDEvidence-based treatmentsIntegrated careCare clinicsImplementation outcomesImplementation trialCare settingsElectronic chart reviewHigh-burden countriesSpecialty servicesHIV prevalenceAssessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study
Esserman D, Greene E, Latham N, Kane M, Lu C, Peduzzi P, Gill T, Ganz D. Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study. Contemporary Clinical Trials 2024, 142: 107572. PMID: 38740298, PMCID: PMC11654751, DOI: 10.1016/j.cct.2024.107572.Peer-Reviewed Original ResearchConceptsElectronic health record dataElectronic health recordsOutcome ascertainmentDevelop Confidence in EldersElectronic health record platformsClinical sitesPrimary care practicesHealth record dataMulti-site trialMulti-site clinical trialCare practicesHealth recordsAssess readinessAcute clinical outcomesHealthcare systemRecord dataClinical trialsReduce injuriesData qualityData comprehensionChecklistStudy dataClinical trial sitesVariable data qualityAscertainmentA Bayesian platform trial design with hybrid control based on multisource exchangeability modelling
Wei W, Blaha O, Esserman D, Zelterman D, Kane M, Liu R, Lin J. A Bayesian platform trial design with hybrid control based on multisource exchangeability modelling. Statistics In Medicine 2024, 43: 2439-2451. PMID: 38594809, PMCID: PMC11325877, DOI: 10.1002/sim.10077.Peer-Reviewed Original ResearchValidation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data
Ganz D, Esserman D, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Greene E. Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data. The Journals Of Gerontology Series A 2024, 79: glae096. PMID: 38566617, PMCID: PMC11167485, DOI: 10.1093/gerona/glae096.Peer-Reviewed Original ResearchConceptsFee-for-serviceFall injuriesMedicare AdvantageMedicare dataTrial armsHealthcare systemDevelop Confidence in EldersArea under the receiver operating characteristic curveMedicare fee-for-serviceStratified resultsMedicareReduce injuriesMedical attentionObservational studyStrideReceiver operating characteristic curveCalendar monthMA dataInjuryData sourcesHealthcareArmReference standardTrialsWindow sizeAssociation between diet quality and ovarian cancer risk and survival
Cao A, Esserman D, Cartmel B, Irwin M, Ferrucci L. Association between diet quality and ovarian cancer risk and survival. Journal Of The National Cancer Institute 2024, 116: 1095-1104. PMID: 38400738, PMCID: PMC11223874, DOI: 10.1093/jnci/djae040.Peer-Reviewed Original ResearchConceptsOvarian cancer riskAll-cause mortalityAssociated with lower all-cause mortalityDiet qualityCancer riskOvarian cancer diagnosisAssociated with ovarian cancer riskPre-diagnosisProspective NIH-AARP DietHealthy Eating Index-2015Cancer diagnosisNIH-AARP DietStop Hypertension scoreCancer registry dataEpithelial ovarian cancerMediterranean diet scoreFood frequency questionnaireCox proportional hazards regressionOvarian cancerProportional hazards regressionHEI-2015Health StudyHypertension scoreDiet scoreFrequency questionnaireAssociation Between Rental Assistance Programs and Undiagnosed Diabetes Among U.S
Gonzalez-Lopez C, Fenelon A, Lipska K, Denary W, Schlesinger P, Esserman D, Keene D. Association Between Rental Assistance Programs and Undiagnosed Diabetes Among U.S. Journal Of General Internal Medicine 2024, 39: 1625-1631. PMID: 38351417, PMCID: PMC11255160, DOI: 10.1007/s11606-024-08673-2.Peer-Reviewed Original ResearchConceptsOdds of undiagnosed diabetesRental assistance programsRental assistanceUndiagnosed diabetesAssistance programsHousing programsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyRates of undiagnosed diabetesAssociated with lower oddsNutrition Examination SurveyAssociated with decreased oddsAssisted housingLogistic regression modelsHousing qualityHealthcare accessPoverty ratioExamination SurveyDiabetes screeningQuasi-experimental approachLower oddsHealth dataAssisted groupAssisted participantsEducation level
Clinical Trials
Current Trials
News
News
- August 05, 2024
Yale partnership seeks to improve HIV prevention and treatment training in Tbilisi, Georgia
- June 25, 2024Source: NIH Fogarty: Global Health Matters May/June 2024
Georgia rising: Partnerships help this nation grow
- June 05, 2024
YSPH appoints two new Biostatistics assistant professors
- August 07, 2023
New Yale Study Shows Aerobic Exercise Relieves Pain for Ovarian Cancer Survivors
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