Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage
van Dijk D, Dhar R, Missarova AM, Espinar L, Blevins WR, Lehner B, Carey LB. Slow-growing cells within isogenic populations have increased RNA polymerase error rates and DNA damage. Nature Communications 2015, 6: 7972. PMID: 26268986, PMCID: PMC4557116, DOI: 10.1038/ncomms8972.Peer-Reviewed Original ResearchMeSH KeywordsCell ProliferationDNA DamageDNA-Directed RNA PolymerasesFlow CytometryFungal ProteinsGene Expression Regulation, FungalRNA, FungalYeastsConceptsTranscriptional stress responseDNA damageDNA damage responseIsogenic populationsRNA polymerase fidelityDamage responseTranscriptional differencesIsogenic cellsEnvironmental stressCell variabilityStress responseGrowth ratePolymerase fidelityCulture conditionsPolymerase error rateOxidative stressCellsSuch cellsSame environmentTranscriptomeTransposonSubpopulationsTranscriptsGenotypicStress