2020
Salvage after Retroperitoneal Kidney Allograft Torsion
Greco JM, Mulligan DC, Yoo PS. Salvage after Retroperitoneal Kidney Allograft Torsion. Case Reports In Transplantation 2020, 2020: 8024598. PMID: 32455047, PMCID: PMC7201506, DOI: 10.1155/2020/8024598.Peer-Reviewed Original ResearchIschemic graft failureRenal allograft failureAllograft failureInfective complicationsPostoperative ultrasoundRetroperitoneal wallKidney transplantationRenal allograftsTransplant recipientsGraft failurePedicle torsionSonographic evaluationManual detorsionRepeat ultrasoundRetroperitoneal spaceVessel patencyClinical signsVascular compromiseRare occurrenceComplicationsNephropexyPotential causesUltrasoundSignsFailure
2016
Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report
Merola J, Yoo PS, Schaub J, Smith JD, Rodriguez-Davalos MI, Tichy E, Mulligan DC, Asch W, Formica R, Kashgarian M, Kulkarni S. Belatacept and Eculizumab for Treatment of Calcineurin Inhibitor-induced Thrombotic Microangiopathy After Kidney Transplantation: Case Report. Transplantation Proceedings 2016, 48: 3106-3108. PMID: 27932157, DOI: 10.1016/j.transproceed.2016.04.005.Peer-Reviewed Original ResearchConceptsCalcineurin inhibitorsHemolytic uremic syndromeThrombotic microangiopathyKidney transplantationUremic syndromeMinimization of CNIsAtypical hemolytic uremic syndromeWithdrawal of tacrolimusEarly graft lossFavorable clinical courseGraft dysfunctionGraft lossImmunosuppression strategiesUsual therapyClinical courseCase reportCTLA-4Endothelial reactionFrequent causeChallenging causeUncontrolled activationMonoclonal antibodiesCellular destructionMicroangiopathyComponent C5Partners in Crime: Kidney Transplantation and Seizure Disorder
Li N, Jean R, Tooley JE, Mulligan DC, Yoo PS. Partners in Crime: Kidney Transplantation and Seizure Disorder. Transplantation Proceedings 2016, 48: 2700-2708. PMID: 27788804, DOI: 10.1016/j.transproceed.2016.06.041.Peer-Reviewed Original ResearchConceptsKidney transplantationSeizure disorderClinical outcomesCommon neurologic complicationNational Inpatient SampleDisease-specific riskCost of careNeurologic complicationsClinical entityClinical complicationsInpatient SampleTransplantationHospitalization statisticsDisordersComplicationsRiskCareComplex management challengesFuture studiesOutcomesMortality
2013
Genetic Differences in Native Americans and Tacrolimus Dosing After Kidney Transplantation
Chakkera HA, Chang Y, Bodner JK, Behmen S, Heilman RL, Reddy KS, Mulligan DC, Moss AA, Khamash H, Katariya N, Hewitt WR, Pitta TL, Frassetto LA. Genetic Differences in Native Americans and Tacrolimus Dosing After Kidney Transplantation. Transplantation Proceedings 2013, 45: 137-141. PMID: 23375287, DOI: 10.1016/j.transproceed.2012.10.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Cohort StudiesFemaleGenetic VariationHumansImmunosuppressive AgentsIndians, North AmericanKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPharmacogeneticsPolymorphism, Single NucleotideTacrolimusTime FactorsConceptsKidney transplant recipientsTrough levelsTacrolimus dosingTransplant recipientsSingle nucleotide polymorphismsDaily tacrolimus doseLower tacrolimus dosesTacrolimus pharmacokinetic parametersTacrolimus trough levelsCaucasian kidney transplant recipientsStable dosesTacrolimus doseKidney transplantationTacrolimus dosesTacrolimus pharmacokineticsMonths posttransplantationOral clearanceTacrolimus clearanceDrug eliminationPharmacokinetic parametersVariant single nucleotide polymorphismsTacrolimusDrug metabolismPharmacokinetic studyLow dosage
2012
Laparoscopic bilateral native nephrectomies with simultaneous kidney transplantation
Martin AD, Mekeel KL, Castle EP, Vaish SS, Martin GL, Moss AA, Mulligan DC, Heilman RL, Reddy KS, Andrews PE. Laparoscopic bilateral native nephrectomies with simultaneous kidney transplantation. BJU International 2012, 110: e1003-e1007. PMID: 22882539, DOI: 10.1111/j.1464-410x.2012.11379.x.Peer-Reviewed Original ResearchConceptsBilateral laparoscopic nephrectomyAutosomal dominant polycystic kidney diseaseSimultaneous kidney transplantationShorter total hospital stayBilateral native nephrectomyTotal hospital stayNative nephrectomyHospital stayKidney transplantationGraft functionRenal transplantPerioperative outcomesKidney transplantLaparoscopic approachSingle tertiary academic centerImmediate graft functionInvasive laparoscopic approachSimultaneous renal transplantMedian hospital stayTertiary academic centerTotal operative durationPolycystic kidney diseaseRenal transplantationComparable morbidityComplication rateUreteral stricture formation in laparoscopically procured living donor kidney transplantation.
Tyson MD, Castle EP, Andrews PE, Heilman RL, Moss AA, Mulligan DC, Reddy KS. Ureteral stricture formation in laparoscopically procured living donor kidney transplantation. Canadian Journal Of Urology 2012, 19: 6188-92. PMID: 22512964.Peer-Reviewed Original ResearchConceptsUreteral stricture formationDelayed graft functionDonor kidney transplantationUreteral strictureGraft functionStricture formationUreteral stentsKidney transplantationStricture diseaseMultivariable logistic regression modelUreteral stricture diseaseLogistic regression modelsStricture groupRetrospective reviewProcedural interventionRisk factorsIntraoperative placementStrictureDonor databasePatientsIncidenceStentsTransplantationDiseaseRegression models
2011
Resolution of Long-Standing Necrobiosis Lipoidica Diabeticorum (NLD) Lesion After Restoration of Euglycemia Following Successful Pancreas After Kidney (PAK) Transplantation: A Case Report
Mazur M, Lowney A, Prigoff J, Heilman R, Chakkera H, Moss A, Mulligan D, Reddy K, Hamawi K. Resolution of Long-Standing Necrobiosis Lipoidica Diabeticorum (NLD) Lesion After Restoration of Euglycemia Following Successful Pancreas After Kidney (PAK) Transplantation: A Case Report. Transplantation Proceedings 2011, 43: 3296-3298. PMID: 22099781, DOI: 10.1016/j.transproceed.2011.10.005.Peer-Reviewed Original ResearchConceptsNecrobiosis lipoidica diabeticorumKidney transplantationPancreas transplantationType I diabetic recipientsTight diabetic controlInflammatory skin disorderRestoration of euglycemiaSuccessful pancreasDiabetic controlDiabetes mellitusDiabetic recipientsImmunosuppressive agentsCase reportUnknown causeCase of resolutionConsistent efficacySkin disordersTransplantationEuglycemiaPatientsPancreasTreatmentImmunosuppressionMellitusRegimenPretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation
Chakkera HA, Weil EJ, Swanson CM, Dueck AC, Heilman RL, Reddy KS, Hamawi K, Khamash H, Moss AA, Mulligan DC, Katariya N, Knowler WC. Pretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation. Diabetes Care 2011, 34: 2141-2145. PMID: 21949218, PMCID: PMC3177751, DOI: 10.2337/dc11-0752.Peer-Reviewed Original ResearchConceptsRisk of NODATNew-onset diabetesRisk scoreKidney transplantationPretransplant variablesSingle-center retrospective cohort studyUnivariate logistic regression analysisMultivariate logistic regression modelRetrospective cohort studySimple risk scoreLogistic regression analysisLogistic regression modelsRelevant cut pointsYear posttransplantCohort studySerum glucoseNODATSummary scoresIntervention studiesDiabetesMultivariate modelCut pointsSum of pointsScoresRegression analysis
2010
Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era
Tyson MD, Castle EP, Ko EY, Andrews PE, Heilman RL, Mekeel KL, Moss AA, Mulligan DC, Reddy KS. Living Donor Kidney Transplantation With Multiple Renal Arteries in the Laparoscopic Era. Urology 2010, 77: 1116-1121. PMID: 21145095, DOI: 10.1016/j.urology.2010.07.503.Peer-Reviewed Original ResearchConceptsMultiple renal arteriesSingle renal arterySlow graft functionDonor kidney transplantationPatients' overall survivalGraft functionKidney transplantationRenal arteryOverall survivalSingle tertiary care academic centerTertiary care academic centerLong-term allograftClavien classification systemDelayed graft functionLong-term outcomesAcute rejectionAllograft survivalUrological complicationsPostoperative complicationsRetrospective reviewLaparoscopic eraAnatomic variationsHigh incidenceAcademic centersMRA groupOutcomes After Simultaneous Pancreas and Kidney Transplantation and the Discriminative Ability of the C-peptide Measurement Pretransplant Among Type 1 and Type 2 Diabetes Mellitus
Chakkera HA, Bodner JK, Heilman RL, Mulligan DC, Moss AA, Mekeel KL, Mazur MJ, Hamawi K, Ray RM, Beck GL, Reddy KS. Outcomes After Simultaneous Pancreas and Kidney Transplantation and the Discriminative Ability of the C-peptide Measurement Pretransplant Among Type 1 and Type 2 Diabetes Mellitus. Transplantation Proceedings 2010, 42: 2650-2652. PMID: 20832562, PMCID: PMC3060052, DOI: 10.1016/j.transproceed.2010.04.065.Peer-Reviewed Original ResearchMeSH KeywordsAdultC-PeptideCreatinineDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesDiabetic RetinopathyFemaleFollow-Up StudiesGlycated HemoglobinGraft RejectionHumansKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPancreas TransplantationRetrospective StudiesSurvival AnalysisTissue DonorsConceptsEnd-stage renal diseaseType of diabetesC-peptideSimultaneous pancreasKidney transplantationPatient survivalGlutamic acid decarboxylase antibodiesType 2 diabetes mellitusDetectable C-peptideMean creatinine clearanceRenal Disease equationModification of DietBody mass indexC-peptide measurementsRegression survival analysisGlycosylate hemoglobinDiabetic ketoacidosisESRD patientsPancreas transplantationT2DM patientsCreatinine clearanceDecarboxylase antibodiesOral hypoglycemicsRenal replacementDiabetes mellitusEarly Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation
Tyson M, Castle E, Andrews P, Heilman R, Mekeel K, Moss A, Mulligan D, Reddy K. Early Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation. Journal Of Urology 2010, 184: 1434-1439. PMID: 20727548, DOI: 10.1016/j.juro.2010.06.013.Peer-Reviewed Original ResearchConceptsPoor early graft functionEarly graft functionLiving-donor kidney transplantationGraft functionDonor kidney transplantationAcute rejectionKidney transplantationMultivariate logistic regression modelGraft function groupDelayed graft functionDonor kidney transplantsInstitutional review boardLogistic regression modelsAllograft survivalGraft nephrectomyVascular complicationsKidney transplantPerioperative parametersIndependent predictorsTransplantation databaseClinical outcomesPatient survivalBlack ethnicityMale genderDonor ageRelationship between Inpatient Hyperglycemia and Insulin Treatment after Kidney Transplantation and Future New Onset Diabetes Mellitus
Chakkera HA, Knowler WC, Devarapalli Y, Weil EJ, Heilman RL, Dueck A, Mulligan DC, Reddy KS, Moss AA, Mekeel KL, Mazur MJ, Hamawi K, Castro JC, Cook CB. Relationship between Inpatient Hyperglycemia and Insulin Treatment after Kidney Transplantation and Future New Onset Diabetes Mellitus. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1669-1675. PMID: 20558559, PMCID: PMC2974410, DOI: 10.2215/cjn.09481209.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsInpatient hyperglycemiaKidney transplantationTransplant recipientsInsulin therapyNondiabetic kidney transplant recipientsDevelopment of NODATRisk of NODATNew-onset diabetesKidney transplant surgeryCapillary blood glucoseNondiabetic patientsYear posttransplantCardiovascular eventsNew onsetDiabetes mellitusMedical therapyAdjusted analysisStudy cohortRetrospective studyTransplant surgeryBlood glucoseSerum glucoseInsulin treatmentNODAT
2009
Pilot Study: Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation
Chakkera HA, Hanson RL, Raza SM, DiStefano JK, Millis MP, Heilman RL, Mulligan DC, Reddy KS, Mazur MJ, Hamawi K, Moss AA, Mekeel KL, Cerhan JR. Pilot Study: Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation. Transplantation Proceedings 2009, 41: 4172-4177. PMID: 20005362, PMCID: PMC3478878, DOI: 10.1016/j.transproceed.2009.08.063.Peer-Reviewed Original ResearchConceptsNew-onset diabetes mellitusDiabetes mellitusRisk factorsKidney transplantationTransplant recipientsFamily historyType 2 diabetes mellitusDevelopment of NODATKidney transplant recipientsTraditional risk factorsGenetic polymorphismsPositive family historyCommon risk factorsGenetic risk factorsLogistic regression modelsNODAT developmentNODAT riskPretransplant obesityNew onsetKidney transplantStudy cohortInsulin secretionNODATT2DMMellitusSimultaneous Heart and Kidney Transplantation After Bridging With The CardioWest Total Artificial Heart
Jaroszewski DE, Pierce CC, Staley LL, Wong R, Scott RR, Steidley EE, Gopalan RS, DeValeria P, Lanza L, Mulligan D, Arabia FA. Simultaneous Heart and Kidney Transplantation After Bridging With The CardioWest Total Artificial Heart. The Annals Of Thoracic Surgery 2009, 88: 1324-1326. PMID: 19766830, DOI: 10.1016/j.athoracsur.2009.02.056.Peer-Reviewed Original ResearchConceptsCardioWest total artificial heartTotal artificial heartRenal failureEnd-stage renal failureTotal artificial heart implantationRisk of mortalityArtificial heart implantationArtificial heartSimultaneous heartCardiac transplantationKidney transplantationRelative contraindicationHeart implantationSuccessful treatmentTransplantationHeartContraindicationsPatientsFailureKidneyMortalityDeceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis
Mekeel KL, Moss AA, Mulligan DC, Chakkera HA, Hamawi K, Mazur MJ, Heilman RL, Reddy KS. Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis. American Journal Of Transplantation 2009, 9: 1666-1670. PMID: 19459799, DOI: 10.1111/j.1600-6143.2009.02663.x.Peer-Reviewed Original ResearchConceptsAcute renal failureGraft functionRenal failureDeceased donor kidney transplantationFull renal functionGood graft functionSlow graft functionDelayed graft functionDonor kidney transplantationCreatinine kinase levelsUrine hemoglobinKidney transplantationMost patientsRenal functionMean creatinineDead patientsImmediate functionKinase levelsSolid organsTransplant communityOrgan donorsRhabdomyolysisPatientsGraftPotential donorsHyperglycemia during the Immediate Period after Kidney Transplantation
Chakkera HA, Weil EJ, Castro J, Heilman RL, Reddy KS, Mazur MJ, Hamawi K, Mulligan DC, Moss AA, Mekeel KL, Cosio FG, Cook CB. Hyperglycemia during the Immediate Period after Kidney Transplantation. Clinical Journal Of The American Society Of Nephrology 2009, 4: 853-859. PMID: 19339426, PMCID: PMC2666437, DOI: 10.2215/cjn.05471008.Peer-Reviewed Original ResearchConceptsNew-onset diabetesKidney transplantationPretransplantation diabetesHospital dischargeImmediate posttransplantation periodPrevalence of hypoglycemiaKidney transplant recipientsStress of surgeryShort-acting insulinEvidence of hyperglycemiaHospital stayImmunosuppression medicationsPharmacologic managementTransplant recipientsHospital phasePosttransplantation periodPharmacy databaseStudy cohortProspective studyTransient hyperglycemiaObservational studyMetabolic effectsHyperglycemiaPatientsTransplantation
2007
Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy
Mekeel KL, Mazur MJ, Reddy KS, Mulligan DC, Heilman RL, Chakkera HA, Andrews PE, Moss AA. Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy. American Journal Of Transplantation 2007, 7: 2039-2041. PMID: 17578504, DOI: 10.1111/j.1600-6143.2007.01870.x.Peer-Reviewed Original ResearchConceptsDonor nephrectomyUrine leakRecipient graft functionGood renal functionLaparoscopic donor nephrectomyComplete deglovingGraft functionKidney transplantationPostoperative courseRenal functionPeritoneal windowLarge urinomaGlue treatmentKidneyUnconcentrated urineKidney surfaceNephrectomyLeakUrinomaPatientsTransplantationDeglovingInjuryTraumaUrine