2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2007
Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types
Nowak L, Sanchez-Vives M, McCormick D. Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types. Cerebral Cortex 2007, 18: 1058-1078. PMID: 17720684, PMCID: PMC3136126, DOI: 10.1093/cercor/bhm137.Peer-Reviewed Original ResearchSelective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses
2006
Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibition
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2002
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
Shu Y, McCormick D. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. Journal Of Neurophysiology 2002, 87: 2571-2576. PMID: 11976393, DOI: 10.1152/jn.00850.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsNRT neuronsPostsynaptic potentialsThalamocortical activityReceptor-mediated inhibitory postsynaptic potentialsSpontaneous inhibitory postsynaptic potentialsImportant inhibitory inputThalamic excitatory inputsThalamic reticular nucleusInhibitory interactionsThalamic reticular neuronsThalamic relay nucleiAverage reversal potentialLocal inhibitory interactionsThalamocortical functionNRT cellsReceptor antagonistReticular neuronsReticular nucleusExcitatory inputsIntracellular recordingsInhibitory inputsRelay nucleiExtracellular recordingsNeuronsNeuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
2001
Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons
Lüthi A, Di Paolo G, Cremona O, Daniell L, De Camilli P, McCormick D. Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons. Journal Of Neuroscience 2001, 21: 9101-9111. PMID: 11717343, PMCID: PMC6763888, DOI: 10.1523/jneurosci.21-23-09101.2001.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornCells, CulturedCerebral CortexElectric StimulationExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidMiceNerve Tissue ProteinsNeural InhibitionNeuronsPatch-Clamp TechniquesPhosphatidylinositolsPhosphoric Monoester HydrolasesSodium Channel BlockersSynapsesSynaptic TransmissionSynaptic VesiclesConceptsPaired-pulse depressionHalf-maximal depressionSteady-state depressionSynaptic depressionWhole-cell patch-clamp recordingsSlow depressionInhibitory synaptic responsesPaired-pulse protocolPrimary cortical culturesHigh-frequency stimulationPatch-clamp recordingsBi-exponential time courseUnitary IPSCsGABA releaseGABAergic transmissionCortical culturesPostsynaptic responsesCortical neuronsInhibitory synapsesSynaptic responsesSynaptojanin 1Presynaptic stimulationInhibitory neuronsRelease probabilityStimulation frequency
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactions
1997
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
Sanchez-Vives M, McCormick D. Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro. Journal Of Neuroscience 1997, 17: 8880-8893. PMID: 9348355, PMCID: PMC6573089, DOI: 10.1523/jneurosci.17-22-08880.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAnticonvulsantsBaclofenBicucullineCerebral CortexConvulsantsElectrophysiologyFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesMaleMembrane PotentialsNeural InhibitionNeural PathwaysNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticThalamic NucleiConceptsGABAB receptorsThalamocortical neuronsPGN neuronsGABAA receptorsThalamocortical cellsGABAB receptor-mediated IPSPsLocal applicationDorsal lateral geniculate nucleusReceptor-mediated IPSPsSynchronous slow oscillationsLow-intensity stimulationLow-threshold Ca2Lateral geniculate nucleusStrong activationPerigeniculate nucleusGeniculate nucleusIntracellular recordingsInhibitory influenceAction potentialsIntensity stimulationThreshold Ca2IPSPsNeuronsSpindle wavesPathological conditionsInhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleus
1992
Neurotransmitter Actions in the Thalamus and Cerebral Cortex
McCormick D. Neurotransmitter Actions in the Thalamus and Cerebral Cortex. Journal Of Clinical Neurophysiology 1992, 9: 212-223. PMID: 1350591, DOI: 10.1097/00004691-199204010-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArousalCerebral CortexHumansNeural InhibitionNeurotransmitter AgentsReceptors, NeurotransmitterSynaptic TransmissionThalamusConceptsGamma-aminobutyric acidCerebral cortexThalamocortical activityInhibitory amino acidsSleep-wake cyclePostsynaptic actionsCortical neuronsNeurotransmitter actionEpileptic seizuresSynaptic informationTransmitter actionThalamusNorepinephrineAcetylcholineCortexNeurotransmittersSeizuresExcitabilityNeocortexHistamineExcitatoryState of activityNeuronsActivity
1989
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicuculline
1988
Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus
McCormick D, Pape H. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988, 334: 246-248. PMID: 3398922, DOI: 10.1038/334246a0.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusRelay cellsGeniculate nucleusDorsal lateral geniculate nucleusMuscarinic receptor-mediated increaseBrainstem cholinergic neuronsCat lateral geniculate nucleusInhibitory postsynaptic potentialsReceptor-mediated increaseDistinctive electrophysiological propertiesUnderlying ionic mechanismsLGNd relay cellsAcetylcholine inhibitsCholinergic neuronsAcetylcholine releaseCerebral cortexCholinergic actionCholinergic axonsPostsynaptic potentialsRelay neuronsCholinergic systemFacilitatory influenceElectrophysiological propertiesCat LGNdIntrageniculate interneurons
1985
Two types of muscarinic response to acetylcholine in mammalian cortical neurons.
McCormick D, Prince D. Two types of muscarinic response to acetylcholine in mammalian cortical neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6344-6348. PMID: 3862134, PMCID: PMC391050, DOI: 10.1073/pnas.82.18.6344.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidInput resistanceMuscarinic responsesPyramidal neuronsPyramidal cellsInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidShort-latency depolarizationsShort-latency inhibitionMammalian cortical neuronsNeuronal input resistanceSlow excitatory responsesApplication of acetylcholineVoltage-dependent depolarizationCholinergic inhibitionExcitatory responsesCholinergic receptorsVoltage-dependent increaseCortical slicesGABAergic interneuronsNicotinic antagonistsCholinergic agonistsCortical neuronsSlow depolarizationNeocortical neurons