2019
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff D, Zagha E, McCarthy E, McCormick D. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex 2019, 30: 421-437. PMID: 31711133, PMCID: PMC7029483, DOI: 10.1093/cercor/bhz206.Peer-Reviewed Original ResearchConceptsVisual detection taskSecondary motor cortexTask performanceTask-related movementsCortical activityMotor cortexDetection taskTask-independent processesOptimal task performanceWidespread cortical activityTask-related changesHead-fixed miceResponse choicesDorsal cortexOrofacial movementsNeural activityTrial variationLick responsesArousal stateTrial variabilityTarget trialsLick rateCortexCortical signalsTrialsDistinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance
Neske G, Nestvogel D, Steffan P, McCormick D. Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance. Journal Of Neuroscience 2019, 39: 10044-10059. PMID: 31672787, PMCID: PMC6978938, DOI: 10.1523/jneurosci.1226-18.2019.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexSensory processingVisual detection performanceCortical neuronal responsesCortical sensory processingWhole-cell recordingsMouse visual systemSensory cortical activityNeuronal membrane potentialArousal levelNeuronal responsivenessFunction of arousalMice increasesNeuronal responsesCortical activityV1 responsesVisual detection taskCortexSensory stimuliSensory responsesLocomotion periodsVisual stimuliBehavioral performanceMembrane potential
2010
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
1988
Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus
McCormick D, Pape H. Acetylcholine inhibits identified interneurons in the cat lateral geniculate nucleus. Nature 1988, 334: 246-248. PMID: 3398922, DOI: 10.1038/334246a0.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusRelay cellsGeniculate nucleusDorsal lateral geniculate nucleusMuscarinic receptor-mediated increaseBrainstem cholinergic neuronsCat lateral geniculate nucleusInhibitory postsynaptic potentialsReceptor-mediated increaseDistinctive electrophysiological propertiesUnderlying ionic mechanismsLGNd relay cellsAcetylcholine inhibitsCholinergic neuronsAcetylcholine releaseCerebral cortexCholinergic actionCholinergic axonsPostsynaptic potentialsRelay neuronsCholinergic systemFacilitatory influenceElectrophysiological propertiesCat LGNdIntrageniculate interneurons