2000
Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spikingCellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro
Sanchez-Vives M, Nowak L, McCormick D. Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro. Journal Of Neuroscience 2000, 20: 4286-4299. PMID: 10818164, PMCID: PMC6772630, DOI: 10.1523/jneurosci.20-11-04286.2000.Peer-Reviewed Original ResearchConceptsSpike frequency adaptationSlow afterhyperpolarizationCortical neuronsFerret primary visual cortexProlonged dischargeCellular mechanismsVisual cortical neuronsPrimary visual cortexSlow spike frequency adaptationIntracellular recordingsIntracellular injectionRightward shiftAfterhyperpolarizationVisual cortexReversal potentialContrast adaptationNeuronsDischarge frequencyMembrane conductanceVivoVisual systemBlockadeCortexImportant role
1998
Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro
Kim U, Mccormick D. Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro. Journal Of Neurophysiology 1998, 80: 1222-1235. PMID: 9744934, DOI: 10.1152/jn.1998.80.3.1222.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthetics, LocalAnimalsApaminBicucullineCalciumCalcium Channel BlockersExcitatory Postsynaptic PotentialsFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesLidocaineMaleNeuronsOmega-Conotoxin GVIAPeptidesPeriodicityPotassiumPotassium ChannelsSodiumTetraethylammoniumTetrodotoxinConceptsApplication of apaminSlow afterhyperpolarizationLow-threshold Ca2Perigeniculate neuronsPlateau potentialsBlock of Ca2Spindle wave generationMedium-duration afterhyperpolarizationGABAergic neuronsTonic dischargeFast afterhyperpolarizationPerigeniculate nucleusIntracellular recordingsAfterhyperpolarizationAction potentialsRefractory periodLocal applicationProlonged depolarizationRepetitive Ca2Spindle wavesReversal potentialNeuronsApaminMembrane conductanceActivation
1997
Inhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleus
1994
Developmental changes in electrophysiological properties of LGNd neurons during reorganization of retinogeniculate connections
Ramoa A, McCormick D. Developmental changes in electrophysiological properties of LGNd neurons during reorganization of retinogeniculate connections. Journal Of Neuroscience 1994, 14: 2089-2097. PMID: 8158259, PMCID: PMC6577110, DOI: 10.1523/jneurosci.14-04-02089.1994.Peer-Reviewed Original ResearchConceptsLGNd neuronsImmature neuronsAction potentialsElectrophysiological propertiesLittle spike frequency adaptationDependent action potentialsAction potential activityEarly postnatal lifeWhole-cell recordingsEarly postnatal developmentPatch-clamp techniqueSpike frequency adaptationHigh input resistanceDorsal LGNImmature synapsesCritical developmental periodRetinogeniculate connectionsMembrane potentialPostnatal weekIntracellular injectionPostnatal lifePostnatal developmentNeuronsInput resistanceFrequency adaptation
1993
Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
Bal T, McCormick D. Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. The Journal Of Physiology 1993, 468: 669-691. PMID: 8254530, PMCID: PMC1143849, DOI: 10.1113/jphysiol.1993.sp019794.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Nucleus reticularis thalamiRhythmic burst firingThreshold Ca2Reticularis thalamiBurst firingExtracellular Ca2Action potentialsOscillatory activityShort-latency burstsSingle spike activityVitro. 2Fast action potentialsNon-selective cationSlow ADPThalamic afferentsTonic dischargeNRT cellsIntracellular recordingsIntracellular injectionSpike AHPsSpike activitySingle neuronesExtracellular applicationReversal potential
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductanceFunctional properties of a slowly inactivating potassium current in guinea pig dorsal lateral geniculate relay neurons
McCormick D. Functional properties of a slowly inactivating potassium current in guinea pig dorsal lateral geniculate relay neurons. Journal Of Neurophysiology 1991, 66: 1176-1189. PMID: 1761979, DOI: 10.1152/jn.1991.66.4.1176.Peer-Reviewed Original Research
1987
Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.
McCormick D, Prince D. Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. The Journal Of Physiology 1987, 393: 743-762. PMID: 2895811, PMCID: PMC1192421, DOI: 10.1113/jphysiol.1987.sp016851.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronesPost-natal developmentImmature neuronesAction potentialsPyramidal neuronesCortical layer V pyramidal neuronsElectrophysiological propertiesRat sensorimotor cortical slicesLayer V pyramidal neuronsDependent action potentialsApparent input resistanceSensorimotor cortical slicesThird week postPyramidal neuronsCortical slicesIntracellular recordingsWeek postCortical neuronesNeuronesInput resistanceAdult neuronesLonger durationSpecific membrane resistanceInward rectificationAge
1986
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick D, Prince D. Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro. The Journal Of Physiology 1986, 375: 169-194. PMID: 2879035, PMCID: PMC1182754, DOI: 10.1113/jphysiol.1986.sp016112.Peer-Reviewed Original ResearchConceptsNon-pyramidal cellsSlow excitatory responsesPyramidal neuronesMechanism of actionAction potentialsExcitatory responsesInhibitory responsesACh applicationGuinea pig cerebral cortexLayer V pyramidal cellsInhibitory post-synaptic potentialsGABAergic synaptic transmissionRelease of GABAShort-latency excitationSlow depolarizing responseApparent input resistanceACh-induced hyperpolarizationApplication of acetylcholineGamma-aminobutyric acidGuinea pig neocortexPost-synaptic potentialsAverage reversal potentialBarrages of excitatoryMinimum onset latencyAction potential generation