1993
Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function
McCormick D. Chapter 36: Actions of acetylcholine in the cerebral cortex and thalamus and implications for function. Progress In Brain Research 1993, 98: 303-308. PMID: 8248519, DOI: 10.1016/s0079-6123(08)62412-7.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAction PotentialsAnimalsCalciumCerebral CortexGliomaNeuroblastomaReceptors, MuscarinicRodentiaSleepThalamusTumor Cells, CulturedWakefulnessConceptsCholinergic neuronsCerebral cortexNicotinic receptorsForebrain activityAction of acetylcholinePost-synaptic responsesAbnormal neuronal functionNicotinic typeCholinergic pathwaysBasal forebrainCholinergic receptorsMuscarinic receptorsCholinergic systemMammalian CNSPhasic responseModulatory controlNeuronal functionAlzheimer's diseaseDistinct subtypesReceptor activationProlonged inhibitionFiring patternsPharmacological propertiesAcetylcholineProlonged changes
1992
Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus
McCormick D. Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus. Journal Of Neuroscience 1992, 12: 278-289. PMID: 1309574, PMCID: PMC6575696, DOI: 10.1523/jneurosci.12-01-00278.1992.Peer-Reviewed Original ResearchConceptsInward current responseSlow depolarizationIntracellular recordingsDorsal lateral geniculate neuronsCat LGNdDorsal lateral geniculate nucleusPertussis toxin-insensitive G proteinToxin-insensitive G proteinGABAB agonist baclofenSingle spike activityActivation of muscarinicLateral geniculate neuronsSubpopulation of neuronsApplication of AChApplication of noradrenalineLateral geniculate nucleusRhythmic oscillationsPossible involvementSingle-spike firingThalamocortical relay cellsG proteinsHigh-frequency burstsLGNd neuronsPostsynaptic actionsAgonist baclofen
1989
Convergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick D, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8098-8102. PMID: 2573061, PMCID: PMC298222, DOI: 10.1073/pnas.86.20.8098.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexPostsynaptic actionsCerebral cortexPutative neurotransmittersMuscarinic receptor agonistApplication of acetylcholineCortical pyramidal cellsGamma-aminobutyric acidDistinct potassium currentsSpecific anatomical connectionsSpike frequency adaptationPostsynaptic receptorsReceptor agonistPyramidal cellsNeurotransmitter systemsM-currentNeuronal firingNeurotransmitter actionPotassium currentCortical activityAnatomical connectionsSerotoninNeurotransmittersNorepinephrineAcetylcholine
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism
1985
Two types of muscarinic response to acetylcholine in mammalian cortical neurons.
McCormick D, Prince D. Two types of muscarinic response to acetylcholine in mammalian cortical neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6344-6348. PMID: 3862134, PMCID: PMC391050, DOI: 10.1073/pnas.82.18.6344.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidInput resistanceMuscarinic responsesPyramidal neuronsPyramidal cellsInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidShort-latency depolarizationsShort-latency inhibitionMammalian cortical neuronsNeuronal input resistanceSlow excitatory responsesApplication of acetylcholineVoltage-dependent depolarizationCholinergic inhibitionExcitatory responsesCholinergic receptorsVoltage-dependent increaseCortical slicesGABAergic interneuronsNicotinic antagonistsCholinergic agonistsCortical neuronsSlow depolarizationNeocortical neurons