2005
Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus
Broberger C, McCormick D. Excitatory Effects of Thyrotropin-Releasing Hormone in the Thalamus. Journal Of Neuroscience 2005, 25: 1664-1673. PMID: 15716402, PMCID: PMC6725920, DOI: 10.1523/jneurosci.3198-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineCalcium SignalingEpilepsyFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsIon TransportMaleMethacholine ChlorideMuscarinic AgonistsPatch-Clamp TechniquesPotassiumPotassium ChannelsReceptors, GABA-AThalamusThyrotropin-Releasing HormoneWakefulnessConceptsThyrotropin-releasing hormoneThalamocortical cellsApplication of TRHNeuropeptide thyrotropin-releasing hormoneRapid eye movement (REM) sleepRhythmic burst firingAnti-epileptic effectsEye movement sleepApplication of bicucullineLateral geniculate nucleusSlow-wave sleepThalamocortical network activityAction potential generationSingle-spike modeNonspecific currentsPerigeniculate neuronsExcitatory effectsGABAergic neuronsMovement sleepPGN neuronsBath applicationBurst firingGeniculate nucleusIntracellular recordingsDirect depolarization
1997
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
Sanchez-Vives M, McCormick D. Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro. Journal Of Neuroscience 1997, 17: 8880-8893. PMID: 9348355, PMCID: PMC6573089, DOI: 10.1523/jneurosci.17-22-08880.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAnticonvulsantsBaclofenBicucullineCerebral CortexConvulsantsElectrophysiologyFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesMaleMembrane PotentialsNeural InhibitionNeural PathwaysNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticThalamic NucleiConceptsGABAB receptorsThalamocortical neuronsPGN neuronsGABAA receptorsThalamocortical cellsGABAB receptor-mediated IPSPsLocal applicationDorsal lateral geniculate nucleusReceptor-mediated IPSPsSynchronous slow oscillationsLow-intensity stimulationLow-threshold Ca2Lateral geniculate nucleusStrong activationPerigeniculate nucleusGeniculate nucleusIntracellular recordingsInhibitory influenceAction potentialsIntensity stimulationThreshold Ca2IPSPsNeuronsSpindle wavesPathological conditionsInhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleus
1996
Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus?
Sanchez-Vives M, Bal T, Kim U, von Krosigk M, McCormick D. Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus? Journal Of Neuroscience 1996, 16: 5923-5941. PMID: 8815875, PMCID: PMC6579195, DOI: 10.1523/jneurosci.16-19-05923.1996.Peer-Reviewed Original ResearchConceptsInterlaminar zonesThalamocortical cellsDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret LGNdLow-threshold Ca2Calbindin-positive cellsLateral geniculate nucleusCalbindin stainingPerigeniculate neuronsPGN cellsContralateral eyeA-laminaeAxon collateralsC laminaePGN neuronsPerigeniculate nucleusGeniculate nucleusIntracellular injectionLamina AElectrophysiological propertiesLocal applicationProlonged depolarizationProlonged hyperpolarizationNeurons
1995
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
McCormick D, Trent F, Ramoa A. Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei. Journal Of Neuroscience 1995, 15: 5739-5752. PMID: 7643215, PMCID: PMC6577643, DOI: 10.1523/jneurosci.15-08-05739.1995.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLow-threshold Ca2PGN neuronsIntracellular recordingsAction potentialsSpindle wavesPostnatal developmentGABAA receptorsRelay cellsElectrophysiological propertiesGABAA antagonist bicuculline methiodideHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusSpindle wave generationNetwork oscillationsDorsal lateral geniculateAction potential firingLateral geniculate nucleusThalamocortical relay cellsSynchronized network oscillationsBarrages of EPSPsLGNd relay cellsHigh-frequency burstsAcetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors
Lee K, McCormick D. Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors. Journal Of Neurophysiology 1995, 73: 2123-2128. PMID: 7623105, DOI: 10.1152/jn.1995.73.5.2123.Peer-Reviewed Original ResearchConceptsAction of acetylcholineSingle spike activityPerigeniculate nucleusPGN cellsGABAergic neuronsSpike activityLocal applicationDirect postsynaptic actionFerret thalamic slicesNicotinic antagonist hexamethoniumIntracellular recording techniquesAction potential firingLow-threshold Ca2Slow hyperpolarizing responseVitro. 2Antagonist hexamethoniumMembrane conductancePostsynaptic actionsGABAergic cellsMuscarinic antagonistMuscarinic receptorsDepolarizing responsePGN neuronsHyperpolarizing responseSynaptic transmissionRole of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro.
Bal T, von Krosigk M, McCormick D. Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. The Journal Of Physiology 1995, 483: 665-685. PMID: 7776250, PMCID: PMC1157809, DOI: 10.1113/jphysiol.1995.sp020613.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsPGN cellsSpindle wave generationLow-threshold Ca2Perigeniculate nucleusSpindle wavesPGN neuronsPostsynaptic potentialsRelay neuronsGABAA receptorsRelay cellsHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusNon-NMDA receptorsShort-duration inhibitory postsynaptic potentialMarked increaseLateral geniculate nucleusExtracellular recording techniquesVitro. 2GABAergic neuronsGABAergic receptorsGABAB receptorsProgressive hyperpolarizationSynaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide