2002
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
Shu Y, McCormick D. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. Journal Of Neurophysiology 2002, 87: 2571-2576. PMID: 11976393, DOI: 10.1152/jn.00850.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsNRT neuronsPostsynaptic potentialsThalamocortical activityReceptor-mediated inhibitory postsynaptic potentialsSpontaneous inhibitory postsynaptic potentialsImportant inhibitory inputThalamic excitatory inputsThalamic reticular nucleusInhibitory interactionsThalamic reticular neuronsThalamic relay nucleiAverage reversal potentialLocal inhibitory interactionsThalamocortical functionNRT cellsReceptor antagonistReticular neuronsReticular nucleusExcitatory inputsIntracellular recordingsInhibitory inputsRelay nucleiExtracellular recordingsNeurons
1997
Inhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleus
1989
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicuculline
1987
Acetylcholine causes rapid nicotinic excitation in the medial habenular nucleus of guinea pig, in vitro
McCormick D, Prince D. Acetylcholine causes rapid nicotinic excitation in the medial habenular nucleus of guinea pig, in vitro. Journal Of Neuroscience 1987, 7: 742-752. PMID: 3549993, PMCID: PMC6569057, DOI: 10.1523/jneurosci.07-03-00742.1987.Peer-Reviewed Original ResearchConceptsMedial habenular nucleusInhibitory responsesMHb neuronsNicotinic receptorsHabenular nucleusACh-induced depolarizationMuscarinic antagonist atropineNicotinic antagonist hexamethoniumIntracellular recording techniquesEffects of AChAction of AChApplication of AChNicotinic agonist nicotineApplication of glutamateAverage reversal potentialNicotinic excitationNicotinic typePostexcitatory inhibitionAntagonist atropineAntagonist hexamethoniumMembrane conductanceACh actionACh responseCentral effectsCholinergic transmission
1986
Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro.
McCormick D, Prince D. Mechanisms of action of acetylcholine in the guinea‐pig cerebral cortex in vitro. The Journal Of Physiology 1986, 375: 169-194. PMID: 2879035, PMCID: PMC1182754, DOI: 10.1113/jphysiol.1986.sp016112.Peer-Reviewed Original ResearchConceptsNon-pyramidal cellsSlow excitatory responsesPyramidal neuronesMechanism of actionAction potentialsExcitatory responsesInhibitory responsesACh applicationGuinea pig cerebral cortexLayer V pyramidal cellsInhibitory post-synaptic potentialsGABAergic synaptic transmissionRelease of GABAShort-latency excitationSlow depolarizing responseApparent input resistanceACh-induced hyperpolarizationApplication of acetylcholineGamma-aminobutyric acidGuinea pig neocortexPost-synaptic potentialsAverage reversal potentialBarrages of excitatoryMinimum onset latencyAction potential generation