Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer
Bronk J, Augustyn A, Mohamed A, Fuller C, Garden A, Moreno A, Lee A, Morrison W, Phan J, Reddy J, Rosenthal D, Spiotto M, Frank S, Dadu R, Busaidy N, Zafereo M, Wang J, Maniakas A, Ferrarotto R, Iyer P, Cabanillas M, Gunn G. Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer. Radiotherapy And Oncology 2024, 202: 110602. PMID: 39489425, DOI: 10.1016/j.radonc.2024.110602.Peer-Reviewed Original ResearchIntensity modulated radiation therapyLoco-regional progressionAnaplastic thyroid cancerTarget volumeConcurrent chemotherapyRadiation therapyThyroid cancerHigh dosesAreas of gross diseaseMedian progression free survivalMedian IMRT doseGross tumor volumeMedian overall survivalProgression free survivalNeo-adjuvant strategiesDeformable image registrationIntensive treatment scheduleLevels II-VDiagnostic CTsIMRT dosePlanning CTsGross diseaseLocoregional diseaseUnresectable diseaseFree survivalAssociation of Biologically Effective Dose and Survival in Patients Receiving Head and Neck Stereotactic Body Radiation Therapy
Márquez C, Phan J, Lee A, Reddy J, Garden A, Gunn G, Frank S, Fuller C, Moreno A, Morrison W, Rosenthal D, Spiotto M. Association of Biologically Effective Dose and Survival in Patients Receiving Head and Neck Stereotactic Body Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e770-e771. DOI: 10.1016/j.ijrobp.2024.07.1694.Peer-Reviewed Original ResearchStereotactic body radiation therapyHead and neck cancerBiologically effective doseRadiation therapyPerformance statusN stagePatients treated with stereotactic body radiation therapyTreat recurrent head and neck cancerPatients treated with initial surgeryRecurrent head and neck cancerHigher biologically effective dosesIncreasing BEDMedian follow-up durationAssociated with improved survivalHead and neck cancer patientsEffective doseNo survival improvementSurgically resected patientsNational Cancer DatabaseFractionation schemeAssociated with enhanced survivalCox regression modelsDose escalationHPV statusResected patientsLongitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study
Koutroumpakis E, Mohamed A, Chaftari P, Rosenthal D, Gujral D, Nutting C, Kamel S, Naser M, Kim P, Bassett R, Fuller C, Mouhayar E, Group A. Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study. Radiotherapy And Oncology 2024, 195: 110220. PMID: 38467343, PMCID: PMC11380547, DOI: 10.1016/j.radonc.2024.110220.Peer-Reviewed Original ResearchIntima-media thicknessGlobal circumferential strainRadiation therapyCarotid arteryHead and neck RTHead and neck cancer patientsHead and neck cancerNeck radiation therapyCircumferential strainNeck cancer patientsCarotid intima-media thicknessCarotid artery injuryArtery duplex studiesCarotid artery stenosisNeck RTNo significant differenceNeck cancerDuplex studiesArterial injuryArtery stenosisCancer patientsMedia thicknessCarotid ultrasoundArterial elastanceCarotidMR-guided stereotactic radiation therapy for head and neck cancers
Wang H, Yang J, Lee A, Phan J, Lim T, Fuller C, Han E, Rhee D, Salzillo T, Zhao Y, Chopra N, Pham M, Castillo P, Sobremonte A, Moreno A, Reddy J, Rosenthal D, Garden A, Wang X. MR-guided stereotactic radiation therapy for head and neck cancers. Clinical And Translational Radiation Oncology 2024, 46: 100760. PMID: 38510980, PMCID: PMC10950743, DOI: 10.1016/j.ctro.2024.100760.Peer-Reviewed Original ResearchAdapt-to-shapeStereotactic body radiation therapyIMRT plansVMAT plansTarget coverageMR-LinacPlan qualityAdapt-to-shape workflowElekta Unity MR-linacMonaco treatment planning systemSoft tissue contrastVMAT treatment plansTreatment planning systemUnity MR-linacCritical organ dosesMR-guided radiotherapyHead and neckAdapt-to-positionRadiation therapyMean doseVarian TrueBeamTrueBeam STxOAR dosesDosimetric differencesElekta Unity