1998
Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation.
Thompson D, Altiere R. Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation. Journal Of Pharmacology And Experimental Therapeutics 1998, 284: 19-24. PMID: 9435155.Peer-Reviewed Original ResearchConceptsAirway smooth muscle contractionSmooth muscle contractionInduction of toneMuscle contractionNerve stimulationNitric oxide-dependent componentAirway smooth muscle toneNitric oxide synthase inhibitorOvalbumin-sensitized guinea pigsNerve-induced relaxationNonadrenergic noncholinergic relaxationElectrical field stimulationOxide synthase inhibitorSmooth muscle toneLevel of toneNoncholinergic relaxationTracheal contractionRelaxant responsesContractile actionAirway tissueNerve activationContractile agonistsMuscle toneField stimulationSynthase inhibitor
1997
Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus.
Cibulsky S, Thompson D. Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. Journal Of Pharmacology And Experimental Therapeutics 1997, 283: 1102-9. PMID: 9399982.Peer-Reviewed Original ResearchConceptsD4-induced contractionAntigen-induced contractionGuinea-pig bronchiLeukotriene D4Endogenous tachykininsPig bronchiNeutral endopeptidaseLeukotriene D4-induced contractionMast cell-derived mediatorsAirway smooth muscle cellsConcentration of tachykininOvalbumin-induced contractionGuinea pig airwaysCell-derived mediatorsPresence of tetrodotoxinNeurokinin receptor antagonistsAngiotensin-converting enzymeSmooth muscle cellsTachykinin involvementTachykininergic responsesContractile actionPig airwaysReceptor antagonistTetrodotoxin treatmentTachykinins
1995
Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig Trachea
Lindsay G, Diamond L, Thompson D, Cibulsky S, Altiere R. Nitric Oxide Role as a Relaxant Agonist and Transmitter of Nonadrenergic Noncholinergic Inhibitory Nerves in Guinea Pig Trachea. CHEST Journal 1995, 107: 125s. PMID: 7874990, DOI: 10.1378/chest.107.3_supplement.125s.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAutonomic Nervous SystemGuinea PigsIn Vitro TechniquesMuscle RelaxationNitric OxideTrachea
1992
Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle
Thompson D, Diamond L, Altiere R. Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulmonary Pharmacology & Therapeutics 1992, 5: 251-255. PMID: 1477481, DOI: 10.1016/0952-0600(92)90067-q.Peer-Reviewed Original ResearchConceptsGuinea pig tracheaGuinea pig tracheal smooth muscleInhibitory actionAlpha-adrenoceptor modulationCholinergic excitatory nervesCholinergic excitatory responsesIntermittent nerve stimulationAlpha-adrenoceptor agonistsPresynaptic inhibitory actionPresynaptic inhibitory effectAction of norepinephrineUse of norepinephrineNorepinephrine-induced inhibitionTracheal smooth musclePretreatment of tissuesConcentration-dependent inhibitionConcentration-dependent mannerCholinergic contractionsPresynaptic alphaCholinergic nervesExcitatory nervesNerve stimulationCholinergic responsesExcitatory responsesSmooth muscleOmega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways.
Altiere R, Diamond L, Thompson D. Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. Journal Of Pharmacology And Experimental Therapeutics 1992, 260: 98-103. PMID: 1309883.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAtropineAutonomic Nervous SystemBronchiCalcium ChannelsCapsaicinCholineElectric StimulationEpinephrineGuanethidineGuinea PigsIndomethacinMaleMuscle ContractionNeurons, AfferentNeurons, EfferentOmega-Conotoxin GVIAPeptides, CyclicPropranololSynaptic TransmissionTachykininsTracheaConceptsSensitive calcium channelsCalcium channelsCholinergic excitatoryNeuronal N-type voltage-sensitive calcium channelsN-type voltage-sensitive calcium channelsNonadrenergic noncholinergic (NANC) inhibitory nervesNonadrenergic noncholinergic inhibitory responsesVoltage-sensitive calcium channelsNoncholinergic inhibitory nervesNoncholinergic inhibitory responsesGuinea pig airwaysGuinea-pig bronchiElectrical field stimulationGuinea pig tracheaMarine snail Conus geographusConcentration-response relationshipAirway nervesAutonomic neurotransmissionTachykininergic responsesExogenous acetylcholineInhibitory nervesContractile responseConotoxin GVIAPig airwaysExcitatory responses
1990
Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig Tracheae
Thompson D, Diamond L, Altiere R. Enzymatic Modulation of Vasoactive Intestinal Peptide and Nonadrenergic Noncholinergic Inhibitory Responses in Guinea Pig Tracheae. American Journal Of Respiratory And Critical Care Medicine 1990, 142: 1119-1123. PMID: 2240834, DOI: 10.1164/ajrccm/142.5.1119.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNANC inhibitory responsesGuinea pig tracheaConcentration-response curvesInhibitory responsesIntestinal peptideInhibitory systemPig tracheaNonadrenergic noncholinergic inhibitory responsesVIP concentration-response curveExogenous vasoactive intestinal peptideRelaxation responseExogenous VIP administrationNANC inhibitory neurotransmitterNANC nerve stimulationNANC relaxation responsesNoncholinergic inhibitory responsesElectrical field stimulationSoybean trypsin inhibitorAdrenergic inhibitoryTachykinin depletionCholinergic excitatoryVIP administrationAutonomic nervesNerve stimulationPresynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea.
Thompson D, Diamond L, Altiere R. Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 306-11. PMID: 2164097.Peer-Reviewed Original ResearchConceptsGuinea pig tracheaNANC inhibitory nervesAlpha-2 adrenoceptor agonistPig tracheaInhibitory nervesAdrenoceptor agonistsExcitatory nervesNerve stimulationAdrenoceptor antagonistInhibitory responsesAlpha-1 adrenoceptor agonistNonadrenergic noncholinergic inhibitory responsesPresynaptic alpha-2 adrenoceptorsAlpha-2 adrenoceptor antagonistAlpha-1 adrenoceptor antagonistAlpha-adrenoceptor modulationCholinergic excitatory nervesNANC inhibitory responsesNoncholinergic excitatory nervesNoncholinergic inhibitory responsesAction of clonidineAlpha-2 adrenoceptorsSympathetic nerve stimulationInhibitory nerve stimulationVasoactive intestinal peptide
1988
The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig
Thompson D, Wells J, Altiere R, Diamond L. The effect of epithelium removal on non-adrenergic, non-cholinergic inhibitory responses in the isolated central airways of the cat and guinea pig. European Journal Of Pharmacology 1988, 145: 231-237. PMID: 3350044, DOI: 10.1016/0014-2999(88)90237-3.Peer-Reviewed Original ResearchConceptsElectrical field stimulationEpithelium removalField stimulationHilar bronchusNon-cholinergic inhibitory responsesTissue sensitivityRelaxation responseNANC relaxation responsesGuinea pig tracheaBronchial sensitivityAirway preparationsContractile responseContractile actionContractile agonistsCentral airwaysPig tracheaAirway epitheliumInhibitory responsesPharmacological agonistsFeline tracheaGuinea pigsBronchusStimulationAgonistsTrachea