Featured Publications
Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program
Stein MB, Levey DF, Cheng Z, Wendt FR, Harrington K, Pathak GA, Cho K, Quaden R, Radhakrishnan K, Girgenti MJ, Ho YA, Posner D, Aslan M, Duman RS, Zhao H, Polimanti R, Concato J, Gelernter J. Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program. Nature Genetics 2021, 53: 174-184. PMID: 33510476, PMCID: PMC7972521, DOI: 10.1038/s41588-020-00767-x.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisAssociation analysisMillion Veteran ProgramGenomic structural equation modelingSignificant lociGenetic varianceGene expressionDrug repositioning candidatesBiological coherenceVeteran ProgramMultiple testing correctionSymptom phenotypeLociRepositioning candidatesAfrican ancestryHeritabilityPhenotypeAncestryExpressionPTSD symptom factorsRegionSubdomainsEnrichment
2024
Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction
Braun A, Shekhar S, Levey D, Straub P, Kraft J, Panagiotaropoulou G, Heilbron K, Awasthi S, Meleka Hanna R, Hoffmann S, Stein M, Lehnerer S, Mergenthaler P, Elnahas A, Topaloudi A, Koromina M, Palviainen T, Asbjornsdottir B, Stefansson H, Skuladóttir A, Jónsdóttir I, Stefansson K, Reis K, Esko T, Palotie A, Leypoldt F, Stein M, Fontanillas P, Kaprio J, Gelernter J, Davis L, Paschou P, Tannemaat M, Verschuuren J, Kuhlenbäumer G, Gregersen P, Huijbers M, Stascheit F, Meisel A, Ripke S. Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction. Nature Communications 2024, 15: 9839. PMID: 39537604, PMCID: PMC11560923, DOI: 10.1038/s41467-024-53595-6.Peer-Reviewed Original ResearchConceptsPerformance of polygenic risk scoresGenome-wide significant hitsGenome-wide association studiesGenome-wide meta-analysisControls of European ancestryGenetic architecturePolygenic risk scoresSignificant hitsAssociation studiesPhenotypic variationPolygenic predictionEuropean ancestryAssociated with early-onsetHuman leukocyte antigen allelesLociEarly-onsetReplication studyNeuromuscular junctionMyasthenia gravisAutoantibody-mediated diseasesAntigen allelesAllelesAncestryDisease manifestationsLate-onset MGAssociation between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program
Craver A, Chen G, Fan R, Levey D, Cohen J. Association between psoriasis and obsessive-compulsive disorder: a case-control study in the All of Us research program. Archives Of Dermatological Research 2024, 316: 280. PMID: 38796663, DOI: 10.1007/s00403-024-03112-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPsoriasisUnited StatesYoung Adult
2023
Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program
Chen G, Fan R, Leasure A, Levey D, Damsky W, Cohen J. Obsessive–compulsive disorder among patients with atopic dermatitis: a case–control study in the All of Us research program. Archives Of Dermatological Research 2023, 316: 11. PMID: 38038754, DOI: 10.1007/s00403-023-02767-3.Peer-Reviewed Original Research
2012
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Molecular Psychiatry 2012, 17: 887-905. PMID: 22584867, PMCID: PMC3427857, DOI: 10.1038/mp.2012.37.Peer-Reviewed Original ResearchConceptsTop candidate genesCandidate genesG protein-coupled receptor signalingGenome-wide association study dataFunctional genomics approachReceptor signalingConvergent functional genomics approachAssociation study dataGene expression studiesFunctional genomicsGenomic approachesGlutamate receptor signalingSignificant genetic overlapSingle nucleotide polymorphismsEnvironmental stressTop genesExpression studiesPathway analysisBiological pathwaysGenetic risk predictionGenesCell adhesionBiological landscapeGenetic overlapSignaling