2016
Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity
Kroemer NB, Small DM. Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity. Physiology & Behavior 2016, 162: 37-45. PMID: 27085908, PMCID: PMC4971522, DOI: 10.1016/j.physbeh.2016.04.020.Peer-Reviewed Original ResearchConceptsFood-related stimuliBrain responsesReward-related learningReward sensitivityReward deficiencyReduced reward sensitivityPrimary food rewardReward receiptMilkshake receiptStriatal responsesReward deficitsFood rewardSubjective valueReinforcement learning frameworkRewardDopamine signalingFood anticipationDorsal striatumAnhedoniaAnticipatoryDopaminergic regionsStimuliConsummatory responsesAlternative viewLearning
2015
Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior
Kroemer NB, Sun X, Veldhuizen MG, Babbs AE, de Araujo IE, Small DM. Weighing the evidence: Variance in brain responses to milkshake receipt is predictive of eating behavior. NeuroImage 2015, 128: 273-283. PMID: 26724781, DOI: 10.1016/j.neuroimage.2015.12.031.Peer-Reviewed Original ResearchConceptsBrain responsesHigher body mass indexAd libitum food consumptionBody mass indexGreater weight lossNucleus Accumbens ResponseFunctional magnetic resonanceMilkshake receiptMass indexPlasma insulinPlasma glucoseMetabolic parametersDietary disinhibitionStriatal activityVariable response patternsWeight lossFood stimuliMetabolic responseSensory stimuliFood consumptionIntra-individual variationVariable responseMilkshakeMagnetic resonanceResponse patterns
2012
Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum