2016
CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells
O’Brien M, Manches O, Wilen C, Gopal R, Huq R, Wu V, Sunseri N, Bhardwaj N. CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells. PLOS Pathogens 2016, 12: e1005553. PMID: 27082754, PMCID: PMC4833349, DOI: 10.1371/journal.ppat.1005553.Peer-Reviewed Original ResearchConceptsPlasmacytoid dendritic cellsAntigen presenting cellsI interferonDendritic cellsNF-κBMature dendritic cell phenotypePotent antigen presenting cellsToll-like receptor 7/9HIV-1 sensingDendritic cell phenotypeInnate immune cellsNF-κB pathwayType I interferonViral nucleic acidsIRF7 pathwayPDC activationImmune cellsPresenting cellsDisease progressionHIV virionsHIV-1IFN productionCD4 receptorInadequate maturationCell phenotype
2014
The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection
Petersen J, Drake MJ, Bruce EA, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K. The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection. PLOS Pathogens 2014, 10: e1003911. PMID: 24516383, PMCID: PMC3916400, DOI: 10.1371/journal.ppat.1003911.Peer-Reviewed Original ResearchConceptsRegulatory pathwaysHuman haploid cellsParallel genetic screensGenetic screenPathogenic New World hantavirusesGenomic screenAndes virusHaploid cellsGene disruptionRNA interferenceANDV entryDeficient cellsCellular requirementsCellular cholesterolRNA virusesANDV infectionLarge familyPharmacologic inhibitionWorldwide distributionAndes Virus InfectionNew World hantavirusesVirus bindingPathwayHost factorsSterol synthesis