2024
Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies.
Faustino E, Kandil S, Leroue M, Sochet A, Kong M, Cholette J, Nellis M, Pinto M, Chegondi M, Ramirez M, Schreiber H, Kerris E, Glau C, Kolmar A, Muisyo T, Sharathkumar A, Polikoff L, Silva C, Ehrlich L, Navarro O, Spinella P, Raffini L, Taylor S, McPartland T, Shabanova V. Protocol for the Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Studies. Pediatric Critical Care Medicine 2024 PMID: 39560771, DOI: 10.1097/pcc.0000000000003648.Peer-Reviewed Original ResearchRandomized clinical trialsDose of enoxaparinCatheter-relatedEarly thromboprophylaxisHigher risk of clinically relevant bleedingRisk of clinically relevant bleedingProphylactic doses of enoxaparinTherapeutic dose of enoxaparinOlder childrenMarkers of thrombin generationClinically relevant bleedingEfficacy of prophylaxisDeep venous thrombosisRemoval of CVCsCritically ill childrenPlatelet-poor plasmaPost hoc analysisGestational ageInternational unitsInstitutional review boardRelevant bleedingProphylactic doseUsual careAge-dependent heterogeneityVenous thrombosis
2023
Performance and reliability assessment of a lower dose, task-based scoliosis radiography protocol in pediatric patients
Al-Dasuqi K, Taylor E, Ehrlich L, Cooperman D, Socci A, Tuason D, Hoerner M, Staib L, Silva C. Performance and reliability assessment of a lower dose, task-based scoliosis radiography protocol in pediatric patients. Pediatric Radiology 2023, 54: 146-153. PMID: 38010426, DOI: 10.1007/s00247-023-05812-5.Peer-Reviewed Original ResearchConceptsDose area productPatient heightAdequate image qualityEffective doseExposure indexMedian effective doseLower radiation exposureComparison of proportionsChi-squared testIntraclass correlation coefficientBland-Altman plotsConsecutive patientsPediatric patientsIncident air kermaDose reductionLow doseSkeletal maturityRadiographsPatientsAir kermaRadiation exposureScoliosis radiographyStatistical significanceDoseSpinal curvature
2022
Ultrasound for Midgut Malrotation and Midgut Volvulus: AJR Expert Panel Narrative Review.
Nguyen HN, Navarro OM, Bloom DA, Feinstein KA, Guillerman RP, Munden MM, Sammer MBK, Silva CT. Ultrasound for Midgut Malrotation and Midgut Volvulus: AJR Expert Panel Narrative Review. American Journal Of Roentgenology 2022, 218: 931-939. PMID: 35107311, DOI: 10.2214/ajr.21.27242.Peer-Reviewed Original ResearchConceptsMidgut malrotationUse of ultrasoundMidgut volvulusNarrative reviewAJR Expert Panel Narrative ReviewUpper gastrointestinal seriesUse of USPediatric surgical emergencyImaging modalitiesFirst-line modalityPreferred imaging modalityBowel ischemiaGastrointestinal seriesSurgical emergencyMalrotationAccurate diagnosisVolvulusModalitiesDiagnosisUltrasound
2021
Artificial Intelligence Algorithm Improves Radiologist Performance in Skeletal Age Assessment: A Prospective Multicenter Randomized Controlled Trial.
Eng DK, Khandwala NB, Long J, Fefferman NR, Lala SV, Strubel NA, Milla SS, Filice RW, Sharp SE, Towbin AJ, Francavilla ML, Kaplan SL, Ecklund K, Prabhu SP, Dillon BJ, Everist BM, Anton CG, Bittman ME, Dennis R, Larson DB, Seekins JM, Silva CT, Zandieh AR, Langlotz CP, Lungren MP, Halabi SS. Artificial Intelligence Algorithm Improves Radiologist Performance in Skeletal Age Assessment: A Prospective Multicenter Randomized Controlled Trial. Radiology 2021, 301: 692-699. PMID: 34581608, DOI: 10.1148/radiol.2021204021.Peer-Reviewed Original ResearchThe course of the duodenum: what path should we take? Reply to Binu et al.
Nguyen HN, Silva CT, Guillerman RP, Navarro OM, Van Tassel D, Sammer MBK. The course of the duodenum: what path should we take? Reply to Binu et al. Pediatric Radiology 2021, 51: 2101-2101. PMID: 34415359, DOI: 10.1007/s00247-021-05164-y.Peer-Reviewed Original ResearchAge-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc AnalysisUntwisting the complexity of midgut malrotation and volvulus ultrasound
Nguyen HN, Navarro OM, Guillerman RP, Silva CT, Sammer MBK. Untwisting the complexity of midgut malrotation and volvulus ultrasound. Pediatric Radiology 2021, 51: 658-668. PMID: 33398405, DOI: 10.1007/s00247-020-04876-x.Peer-Reviewed Original ResearchConceptsMidgut volvulusMidgut malrotationCommon conditionAcute abdominal signsUpper gastrointestinal seriesUpper GI seriesHypertrophic pyloric stenosisDiagnostic imaging testsOral contrast agentAbdominal signsAbdominal USGastrointestinal seriesGI seriesPrompt treatmentClinical presentationPyloric stenosisDiagnostic findingsImaging testsPictorial essayUS protocolVolvulusMalrotationContrast agentsEnterocolitisAppendicitis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialPearls and Pitfalls in Pediatric Thyroid Imaging
Silva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.Peer-Reviewed Original ResearchConceptsDiffuse thyroid enlargementThyroid enlargementCongenital hypothyroidismThyroid nodulesThyroid imagingPediatric age groupRole of imagingRisk of malignancyPermanent congenital hypothyroidismGraves' diseasePediatric populationHashimoto's diseaseNodular hyperplasiaPapillary carcinomaThyroid glandAccurate diagnosisAge groupsThyroid dysgenesisHypothyroidismDiseaseChildrenTeenage girlsImagingManagement recommendationsEnlargement
2019
Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography.
Riera A, Langhan M, Silva CT. Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. Pediatric Emergency Care 2019, 36: e30-e32. PMID: 31433363, DOI: 10.1097/pec.0000000000001879.Peer-Reviewed Original ResearchConceptsIleocolic intussusceptionCare ultrasoundIschemic bowel injurySignificant inflammatory changesBowel injuryInitial workupInflammatory changesSurgical reductionTerminal ileitisTerminal ileumCare ultrasonographyRadiology ultrasoundIntussusceptionAcademic centersReduction attemptsSensitivity of studiesSpontaneous reductionTest characteristicsUltrasoundDiagnostic techniquesRadiologyIleitisUltrasonographyIleumInjuryReevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients
Riera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.Peer-Reviewed Original ResearchConceptsBlunt abdominal trauma patientsAbdominal trauma patientsFree fluidTrauma patientsUpper quadrantPredictive valueLevel I pediatric trauma centerPediatric trauma centerRetrospective chart reviewRight upper quadrantFAST examinationNegative predictive valuePositive predictive valueNegative likelihood ratioChart reviewBAT patientsMedian ageTrauma centerUpper abdomenIntraperitoneal fluidMAIN OUTCOMEPhysiologic amountsTrauma (FAST) examinationPatientsFocused assessmentProviding Expert Pediatric Teleradiology Services Around the Globe: The World Federation of Pediatric Imaging Experience
Otero HJ, Andronikou S, Grassi DC, Silva CT. Providing Expert Pediatric Teleradiology Services Around the Globe: The World Federation of Pediatric Imaging Experience. Journal Of The American College Of Radiology 2019, 17: 53-55. PMID: 31278921, DOI: 10.1016/j.jacr.2019.06.006.Peer-Reviewed Original ResearchEffect of Reader and Patient Parameters on the Performance of Last-Image-Hold for Fluoroscopic Grading of Vesicoureteric Reflux.
Mian AY, Mills IP, Sheridan AD, Ehrlich LJ, Baker KE, Tilak G, Staib LH, Silva CT. Effect of Reader and Patient Parameters on the Performance of Last-Image-Hold for Fluoroscopic Grading of Vesicoureteric Reflux. American Journal Of Roentgenology 2019, 212: 968-975. PMID: 30807219, DOI: 10.2214/ajr.18.20273.Peer-Reviewed Original ResearchPatient parametersVesicoureteric refluxReflux gradingCommon misclassificationExperienced readersGrade 2 refluxPerfect overall agreementSubstantial overall agreementRenal fossaSupplemental evaluationRetrospective evaluationVCUG examinationsRefluxBlinded readersKappa testOverall misclassificationFive-year periodDegree of agreementGradingOverall agreementPearson product-moment correlationsRate of misclassification
2018
Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents
Faustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisExtremity deep venous thrombosisIll adolescentsVenous thrombosisFrequency of DVTLower extremity deep venous thrombosisCases of DVTBilateral deep venous thrombosisPediatric intensive care unitInvasive mechanical ventilationCentral venous catheterizationIntensive care unitPharmacologic prophylaxisTherapeutic anticoagulationCohort studyPulmonary embolismCardiopulmonary supportCare unitMechanical ventilationVenous catheterizationSevere illnessSerial sonogramsLower extremitiesEpidemiologyThrombosis
2017
Abusive fracture incidence over three decades at a level 1 pediatric trauma center
Sharkey MS, Buesser KE, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Leventhal JM. Abusive fracture incidence over three decades at a level 1 pediatric trauma center. Child Abuse & Neglect 2017, 76: 364-371. PMID: 29195174, DOI: 10.1016/j.chiabu.2017.11.008.Peer-Reviewed Original ResearchConceptsPediatric trauma centerLevel 1 pediatric trauma centerAbusive fracturesTrauma centerED visitsSingle pediatric trauma centerSame trauma centerSingle-institution reviewFracture incidenceInstitution reviewEmergency departmentIncidenceAgeChildrenConsensus ratingsRecent dataTime periodVisitsFracturesCurrent studyRecent time periodPeriodGeographic regionsCenterStudyInter-rater reliability of physical abuse determinations in young children with fractures
Buesser KE, Leventhal JM, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Sharkey MS. Inter-rater reliability of physical abuse determinations in young children with fractures. Child Abuse & Neglect 2017, 72: 140-146. PMID: 28802910, DOI: 10.1016/j.chiabu.2017.08.001.Peer-Reviewed Original ResearchConceptsChild abuse pediatriciansModerate agreementPediatric emergency departmentMedical record dataYoung childrenAbusive injuriesEmergency departmentJoint ratingsClinical detailsInter-rater reliabilityPediatric radiologistsClinical scenariosMedical providersPairs of ratersPediatric orthopaedistsLevel of agreementOrthopaedistsRecord dataCliniciansGold standardIndependent ratingsRadiologistsChildrenExtent of agreementPhysiciansAssessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction
Jindal G, Graeber BL, Staib LH, Silva CT. Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction. Pediatric Radiology 2017, 47: 1594-1598. PMID: 28681232, DOI: 10.1007/s00247-017-3920-z.Peer-Reviewed Original ResearchCongenital Cystic Lung Lesions
Hardee S, Tuzovic L, Silva CT, Cowles RA, Copel J, Morotti RA. Congenital Cystic Lung Lesions. Pediatric And Developmental Pathology 2017, 20: 403-410. PMID: 28812458, DOI: 10.1177/1093526617698604.Peer-Reviewed Original ResearchConceptsCongenital cystic lung lesionsCongenital pulmonary airway malformationCystic lung lesionsBronchopulmonary sequestrationLung lesionsPrenatal ultrasoundSingle tertiary care centerPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPostnatal imagingRetrospective reviewPathological findingsPathology databaseRare pathologySurgical interventionBronchial atresiaPrenatal coursePathologic diagnosisPathology examinationCare center
2016
602
Faustino E, Li S, Pinto M, Trakas E, Gertz S, Miksa M, Silva C. 602. Critical Care Medicine 2016, 44: 227. DOI: 10.1097/01.ccm.0000509279.64732.0c.Peer-Reviewed Original ResearchCONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH
Hardee S, Tuzovic L, Silva C, Cowles R, Copel J, Morotti R. CONGENITAL CYSTIC LUNG LESIONS: EVOLUTION FROM IN-UTERO TO PATHOLOGY DIAGNOSIS - A MULTIDISCIPLINARY APPROACH. Pediatric And Developmental Pathology 2016 DOI: 10.2350/16-05-1815-oa.1.Peer-Reviewed Original ResearchCongenital cystic lung lesionsCongenital pulmonary airway malformationBronchopulmonary sequestrationPrenatal ultrasoundSingle tertiary care centerCystic lung lesionsPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPathological findingsPostnatal imagingRetrospective reviewPathology databaseSurgical interventionRare pathologyBronchial atresiaLung lesionsPathologic diagnosisPrenatal coursePathology examinationCare center