2023
Performance and reliability assessment of a lower dose, task-based scoliosis radiography protocol in pediatric patients
Al-Dasuqi K, Taylor E, Ehrlich L, Cooperman D, Socci A, Tuason D, Hoerner M, Staib L, Silva C. Performance and reliability assessment of a lower dose, task-based scoliosis radiography protocol in pediatric patients. Pediatric Radiology 2023, 54: 146-153. PMID: 38010426, DOI: 10.1007/s00247-023-05812-5.Peer-Reviewed Original ResearchConceptsDose area productPatient heightAdequate image qualityEffective doseExposure indexMedian effective doseLower radiation exposureComparison of proportionsChi-squared testIntraclass correlation coefficientBland-Altman plotsConsecutive patientsPediatric patientsIncident air kermaDose reductionLow doseSkeletal maturityRadiographsPatientsAir kermaRadiation exposureScoliosis radiographyStatistical significanceDoseSpinal curvature
2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Shabanova V, Raffini LJ, Kandil SB, Li S, Pinto MG, Cholette JM, Hanson SJ, Nellis ME, Silva CT, Chima R, Sharathkumar A, Thomas KA, McPartland T, Tala JA, Spinella PC. Efficacy of Early Prophylaxis Against Catheter-Associated Thrombosis in Critically Ill Children: A Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2020, 49: e235-e246. PMID: 33372745, PMCID: PMC7902342, DOI: 10.1097/ccm.0000000000004784.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisDeep venous thrombosisUsual care armCentral venous cathetersVenous thrombosisClinical trialsEnoxaparin armCare armVenous cathetersEarly prophylaxisIll childrenThrombin generationPhase 2bCatheter-Associated ThrombosisInternational units/mLAnti-Xa levelsCritically Ill ChildrenRandomized clinical trialsEndogenous thrombin potentialRelevant bleedingUsual careTrial armsRisk ratioThrombin potentialPearls and Pitfalls in Pediatric Thyroid Imaging
Silva CT, Navarro OM. Pearls and Pitfalls in Pediatric Thyroid Imaging. Seminars In Ultrasound CT And MRI 2020, 41: 421-432. PMID: 32980089, DOI: 10.1053/j.sult.2020.05.007.Peer-Reviewed Original ResearchConceptsDiffuse thyroid enlargementThyroid enlargementCongenital hypothyroidismThyroid nodulesThyroid imagingPediatric age groupRole of imagingRisk of malignancyPermanent congenital hypothyroidismGraves' diseasePediatric populationHashimoto's diseaseNodular hyperplasiaPapillary carcinomaThyroid glandAccurate diagnosisAge groupsThyroid dysgenesisHypothyroidismDiseaseChildrenTeenage girlsImagingManagement recommendationsEnlargement
2019
Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography.
Riera A, Langhan M, Silva CT. Terminal Ileitis Presenting With a Spontaneously Reduced Ileocolic Intussusception Diagnosed by Point-of-Care Ultrasonography. Pediatric Emergency Care 2019, 36: e30-e32. PMID: 31433363, DOI: 10.1097/pec.0000000000001879.Peer-Reviewed Original ResearchConceptsIleocolic intussusceptionCare ultrasoundIschemic bowel injurySignificant inflammatory changesBowel injuryInitial workupInflammatory changesSurgical reductionTerminal ileitisTerminal ileumCare ultrasonographyRadiology ultrasoundIntussusceptionAcademic centersReduction attemptsSensitivity of studiesSpontaneous reductionTest characteristicsUltrasoundDiagnostic techniquesRadiologyIleitisUltrasonographyIleumInjuryReevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients
Riera A, Hayward H, Silva C, Chen L. Reevaluation of FAST Sensitivity in Pediatric Blunt Abdominal Trauma Patients. Pediatric Emergency Care 2019, 37: e1012-e1019. PMID: 31356479, DOI: 10.1097/pec.0000000000001877.Peer-Reviewed Original ResearchConceptsBlunt abdominal trauma patientsAbdominal trauma patientsFree fluidTrauma patientsUpper quadrantPredictive valueLevel I pediatric trauma centerPediatric trauma centerRetrospective chart reviewRight upper quadrantFAST examinationNegative predictive valuePositive predictive valueNegative likelihood ratioChart reviewBAT patientsMedian ageTrauma centerUpper abdomenIntraperitoneal fluidMAIN OUTCOMEPhysiologic amountsTrauma (FAST) examinationPatientsFocused assessment
2018
Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents
Faustino EVS, Shabanova V, Pinto MG, Li S, Trakas E, Miksa M, Gertz S, Polikoff LA, Napolitano M, Brudnicki AR, Tala JA, Silva CT, Investigators T, Miksa M, Taragin B, Blickman J, Taillie E, Trakas E, Balasco A, Herliczek T, Polikoff L, Dovi G, Napolitano M, Gertz S, Riordan M, Zasa J, Brudnicki A, Eldridge P, Li S, Pinto M, Faustino E, Silva C, Tala J. Epidemiology of Lower Extremity Deep Venous Thrombosis in Critically Ill Adolescents. The Journal Of Pediatrics 2018, 201: 176-183.e2. PMID: 29891258, DOI: 10.1016/j.jpeds.2018.05.006.Peer-Reviewed Original ResearchConceptsDeep venous thrombosisExtremity deep venous thrombosisIll adolescentsVenous thrombosisFrequency of DVTLower extremity deep venous thrombosisCases of DVTBilateral deep venous thrombosisPediatric intensive care unitInvasive mechanical ventilationCentral venous catheterizationIntensive care unitPharmacologic prophylaxisTherapeutic anticoagulationCohort studyPulmonary embolismCardiopulmonary supportCare unitMechanical ventilationVenous catheterizationSevere illnessSerial sonogramsLower extremitiesEpidemiologyThrombosis
2017
Abusive fracture incidence over three decades at a level 1 pediatric trauma center
Sharkey MS, Buesser KE, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Leventhal JM. Abusive fracture incidence over three decades at a level 1 pediatric trauma center. Child Abuse & Neglect 2017, 76: 364-371. PMID: 29195174, DOI: 10.1016/j.chiabu.2017.11.008.Peer-Reviewed Original ResearchConceptsPediatric trauma centerLevel 1 pediatric trauma centerAbusive fracturesTrauma centerED visitsSingle pediatric trauma centerSame trauma centerSingle-institution reviewFracture incidenceInstitution reviewEmergency departmentIncidenceAgeChildrenConsensus ratingsRecent dataTime periodVisitsFracturesCurrent studyRecent time periodPeriodGeographic regionsCenterStudyInter-rater reliability of physical abuse determinations in young children with fractures
Buesser KE, Leventhal JM, Gaither JR, Tate V, Cooperman DR, Moles RL, Silva CT, Ehrlich LJ, Sharkey MS. Inter-rater reliability of physical abuse determinations in young children with fractures. Child Abuse & Neglect 2017, 72: 140-146. PMID: 28802910, DOI: 10.1016/j.chiabu.2017.08.001.Peer-Reviewed Original ResearchConceptsChild abuse pediatriciansModerate agreementPediatric emergency departmentMedical record dataYoung childrenAbusive injuriesEmergency departmentJoint ratingsClinical detailsInter-rater reliabilityPediatric radiologistsClinical scenariosMedical providersPairs of ratersPediatric orthopaedistsLevel of agreementOrthopaedistsRecord dataCliniciansGold standardIndependent ratingsRadiologistsChildrenExtent of agreementPhysiciansAssessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction
Jindal G, Graeber BL, Staib LH, Silva CT. Assessment of a modified technique for air delivery during fluoroscopic-monitored pneumatic intussusception reduction. Pediatric Radiology 2017, 47: 1594-1598. PMID: 28681232, DOI: 10.1007/s00247-017-3920-z.Peer-Reviewed Original ResearchCongenital Cystic Lung Lesions
Hardee S, Tuzovic L, Silva CT, Cowles RA, Copel J, Morotti RA. Congenital Cystic Lung Lesions. Pediatric And Developmental Pathology 2017, 20: 403-410. PMID: 28812458, DOI: 10.1177/1093526617698604.Peer-Reviewed Original ResearchConceptsCongenital cystic lung lesionsCongenital pulmonary airway malformationCystic lung lesionsBronchopulmonary sequestrationLung lesionsPrenatal ultrasoundSingle tertiary care centerPulmonary airway malformationTertiary care centerFinal pathologic diagnosisCorrelate imagingCPAM lesionsAirway malformationExcellent prognosisPostnatal imagingRetrospective reviewPathological findingsPathology databaseRare pathologySurgical interventionBronchial atresiaPrenatal coursePathologic diagnosisPathology examinationCare center
2015
Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children
Li S, Silva CT, Brudnicki AR, Baker KE, Tala JA, Pinto MG, Polikoff LA, Qin L, Faustino EV, Northeast Pediatric Critical Care Research Consortium. Diagnostic accuracy of point-of-care ultrasound for catheter-related thrombosis in children. Pediatric Radiology 2015, 46: 219-228. PMID: 26440129, PMCID: PMC4738063, DOI: 10.1007/s00247-015-3467-9.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionCausalityCentral Venous CathetersChildChild, PreschoolCohort StudiesConnecticutFemaleHumansInfantInfant, NewbornMalePoint-of-Care TestingPrevalenceReproducibility of ResultsRisk FactorsSensitivity and SpecificitySex DistributionUltrasonographyUpper Extremity Deep Vein ThrombosisConceptsCatheter-related thrombosisCare ultrasoundChance-corrected agreementIll childrenCare USCentral venous catheter-related thrombosisPediatric radiologistsDeep venous thrombosisCentral venous cathetersIntensive care unitVenous cathetersVenous thrombosisCare unitSubclavian veinThrombosisAccuracy of pointCatheterSensitivity of pointDiscordant readingsDiagnostic accuracyMulticenterUltrasoundRadiology departmentChildrenPhysiciansPrevalence of post‐thrombotic syndrome after cardiac catheterization
Luceri MJ, Tala JA, Weismann CG, Silva CT, Faustino EV. Prevalence of post‐thrombotic syndrome after cardiac catheterization. Pediatric Blood & Cancer 2015, 62: 1222-1227. PMID: 25663038, PMCID: PMC4433560, DOI: 10.1002/pbc.25438.Peer-Reviewed Original ResearchConceptsPost-thrombotic syndromeCardiac catheterizationFirst catheterizationCyanotic congenital heart diseaseManco-Johnson instrumentDeep venous thrombosisSurvival of childrenTime of enrollmentCongenital heart diseaseCross-sectional studyChronic complicationsCommon complicationMedian ageVenous thrombosisValvular insufficiencyFemoral veinHeart diseaseSignificant syndromeAntithrombotic agentsCatheterizationSyndromeDisease increasesThrombosisComplicationsChildren
2014
Postnatal sonographic spectrum of prenatally detected abdominal and pelvic cysts.
Silva CT, Engel C, Cross SN, Copel JE, Morotti RA, Baker KE, Goodman TR. Postnatal sonographic spectrum of prenatally detected abdominal and pelvic cysts. American Journal Of Roentgenology 2014, 203: w684-96. PMID: 25415735, DOI: 10.2214/ajr.13.12371.Peer-Reviewed Original ResearchBlood glucose as a marker of venous thromboembolism in critically ill children
Tala JA, Silva CT, Pemira S, Vidal E, Faustino EV. Blood glucose as a marker of venous thromboembolism in critically ill children. Journal Of Thrombosis And Haemostasis 2014, 12: 891-896. PMID: 24708410, PMCID: PMC4055532, DOI: 10.1111/jth.12583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsBiomarkersBlood GlucoseChildChild, PreschoolChi-Square DistributionCritical IllnessFemaleHumansHyperglycemiaInfantIntensive Care Units, PediatricLogistic ModelsMaleOdds RatioPredictive Value of TestsPrognosisRetrospective StudiesRisk FactorsTime FactorsVenous ThromboembolismConceptsMaximum blood glucoseVenous thromboembolismBlood glucoseIll childrenOdds ratioPediatric intensive care unitRetrospective cohort studyCentral venous cathetersNon-diabetic childrenSeverity of illnessIntensive care unitLogistic regression modelsCohort studyVenous cathetersAntithrombotic useDiabetes mellitusPrimary outcomeCare unitHyperglycemic subjectsPrior diagnosisThromboembolismHyperglycemiaMechanical ventilatorPotential predictorsSubject characteristics
2013
A prospective comparison of intestinal sonography and abdominal radiographs in a neonatal intensive care unit
Silva CT, Daneman A, Navarro OM, Moineddin R, Levine D, Moore AM. A prospective comparison of intestinal sonography and abdominal radiographs in a neonatal intensive care unit. Pediatric Radiology 2013, 43: 1453-1463. PMID: 24026851, DOI: 10.1007/s00247-013-2777-z.Peer-Reviewed Original ResearchConceptsIntestinal gas patternsSpectrum of appearancesAbdominal radiographsIntestinal pathologySonographic findingsFree fluidNeonatal intensive care unitIntensive care unitAbility of sonographyIntestinal wall thickeningGas patternIntestinal sonographyIntestinal dilatationCare unitGestational agePatient chartsIntensive careIntestinal loopsSonographic abnormalitiesBackgroundNo studyProspective comparisonIntestinal perfusionFluid collectionClinical informationEnterocolitisIntestinal Blood Flow by Doppler Ultrasound: The Impact of Gestational Age and Time from First Enteral Feeding in Preterm Neonates
Thompson A, Silva CT, Gork AS, Wang D, Ehrenkranz RA. Intestinal Blood Flow by Doppler Ultrasound: The Impact of Gestational Age and Time from First Enteral Feeding in Preterm Neonates. American Journal Of Perinatology 2013, 31: 261-268. PMID: 23729284, DOI: 10.1055/s-0033-1347365.Peer-Reviewed Original ResearchConceptsSMA peak systolic velocityPeak systolic velocityFirst enteral feedingEnteral feedingGestational ageFeeding intolerancePreterm neonatesEnteral feedsGA groupSuperior mesenteric artery peak systolic velocityFirst enteral feedIntestinal blood flowSignificant differencesSystolic velocityDoppler ultrasoundBlood flowGroup IIGroup IGroup IIIPatientsIntoleranceWeeksNeonatesTime 2Age
2012
Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children
Faustino EV, Spinella PC, Li S, Pinto MG, Stoltz P, Tala J, Card ME, Northrup V, Baker KE, Goodman TR, Chen L, Silva CT. Incidence and Acute Complications of Asymptomatic Central Venous Catheter–Related Deep Venous Thrombosis in Critically Ill Children. The Journal Of Pediatrics 2012, 162: 387-391. PMID: 22883418, PMCID: PMC3575007, DOI: 10.1016/j.jpeds.2012.06.059.Peer-Reviewed Original ResearchConceptsCVC-related deep venous thrombosisDeep venous thrombosisCentral venous cathetersIntensive care unitAcute complicationsIll childrenVenous cathetersVenous thrombosisCare unitPediatric intensive care unitProspective cohort studyChronic complicationsHospital lengthCohort studyPatient demographicsPulmonary embolismCompression ultrasonographyMechanical ventilationHigher oddsCurrent incidenceColor DopplerComplicationsCVC characteristicsLarger studyThrombosisEarly assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma
Silva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.Peer-Reviewed Original ResearchConceptsPediatric extremity traumaExtremity traumaSite of painPediatric emergency departmentSite of injuryPain sitesEmergency departmentLimb traumaContralateral limbExtremity radiographsFracture sitePatientsFurther evaluationRadiographsTraumaSame dayEarly assessmentWhole limbIntellectual disabilityLocal hyperthermiaYoung childrenDITIEfficacyLimbFractures
2011
A unique case of rhabdoid tumor presenting as hemoperitoneum in an infant
Malhotra Y, Fitzgerald TN, Jubinsky PT, Harper H, Silva CT, Zambrano E, Diefenbach KA, Moss RL, Bhandari V. A unique case of rhabdoid tumor presenting as hemoperitoneum in an infant. Journal Of Pediatric Surgery 2011, 46: 247-251. PMID: 21238679, DOI: 10.1016/j.jpedsurg.2010.08.051.Peer-Reviewed Original Research