2016
CD8+ T cells mediate antibody-independent platelet clearance in mice
Arthur CM, Patel SR, Sullivan HC, Winkler AM, Tormey CA, Hendrickson JE, Stowell SR. CD8+ T cells mediate antibody-independent platelet clearance in mice. Blood 2016, 127: 1823-1827. PMID: 26787734, PMCID: PMC4825415, DOI: 10.1182/blood-2015-10-673426.Peer-Reviewed Original ResearchConceptsPlatelet clearancePlatelet removalImportant therapeutic interventionPlatelet transfusionsNonimmune mechanismsT cellsTherapeutic outcomesAlloantibodiesTherapeutic interventionsAppropriate managementTransfusionClearanceSole mediatorPatientsVariety of mechanismsComplete absenceNumerous studiesCD8Clear mechanismCellsAbsenceMiceIndividualsPrevention
2014
The Influence of Clinical and Biological Factors on Transfusion-Associated Non-ABO Antigen Alloimmunization: Responders, Hyper-Responders, and Non-Responders
Gehrie EA, Tormey CA. The Influence of Clinical and Biological Factors on Transfusion-Associated Non-ABO Antigen Alloimmunization: Responders, Hyper-Responders, and Non-Responders. Transfusion Medicine And Hemotherapy 2014, 41: 420-429. PMID: 25670929, PMCID: PMC4280450, DOI: 10.1159/000369109.Peer-Reviewed Original ResearchRed blood cellsPatient populationInfluence of ClinicalDevelopment of antibodiesImportant clinical consequencesDiverse patient populationsBlood group antigensRBC alloimmunizationChronic transfusionRBC alloantibodiesHyper respondersClinical circumstancesClinical consequencesAlloimmunizationMedical literatureTransfusionAlloantibodiesGroup antigensRespondersBlood cellsTransfusion medicinePatientsBiological factorsIndividualsPregnancy