2023
Lipid Sorting and Organelle Identity.
Kim Y, Burd C. Lipid Sorting and Organelle Identity. Cold Spring Harbor Perspectives In Biology 2023, 15: a041397. PMID: 37487627, PMCID: PMC10547387, DOI: 10.1101/cshperspect.a041397.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTrafficking of lipidsSynthesis of sphingolipidsLipid transfer proteinOrganelle identityMembrane traffickingOrganelle homeostasisSoluble lipid transfer proteinsBulk membrane propertiesOrganelle functionGolgi networkLipid sortingNet membrane chargeOrganelle membranesPlasma membraneEndoplasmic reticulumParticular lipidsOrganellesTransfer proteinLeaflet asymmetryEssential roleBulk membraneCholesterol fluxTraffickingMembraneSecretory
2018
Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network
Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Developmental Cell 2018, 47: 464-478.e8. PMID: 30393074, PMCID: PMC6261503, DOI: 10.1016/j.devcel.2018.10.012.Peer-Reviewed Original ResearchConceptsTrans-Golgi networkTGN membranesCell surface transportProtein sortingTrafficking pathwaysSecretion pathwaySecretory proteinsSphingomyelin synthesisSorting mechanismLipid synthesisProteinVesicular carriersCab45Sphingomyelin contentNew lipidSortingPrincipal functionMembranePathwayCore componentLipidsGolgiSurface transportExportActivity
2001
FYVE Domain Targets Pib1p Ubiquitin Ligase to Endosome and Vacuolar Membranes*
Shin M, Ogburn K, Varban O, Gilbert P, Burd C. FYVE Domain Targets Pib1p Ubiquitin Ligase to Endosome and Vacuolar Membranes*. Journal Of Biological Chemistry 2001, 276: 41388-41393. PMID: 11526110, DOI: 10.1074/jbc.m105665200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceEndosomesGreen Fluorescent ProteinsIntracellular MembranesLigasesLuminescent ProteinsMolecular Sequence DataPhosphatidylinositol 3-KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidSignal TransductionUbiquitin-Protein Ligase ComplexesUbiquitin-Protein LigasesVacuolesConceptsPI3K productsVacuolar membraneFYVE domainUbiquitin ligaseK productRING-type ubiquitin ligaseUbiquitin ligase activityFYVE fingerFinger motifEukaryotic cellsYeast SaccharomycesCellular proteinsRING domainLigase activityDeletional analysisFusion proteinStructural domainsHistidine residuesPrimary structurePI3KFluorescence microscopyProteinLigaseBindsMembrane
2000
GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*
Gilbert P, Burd C. GDP Dissociation Inhibitor Domain II Required for Rab GTPase Recycling*. Journal Of Biological Chemistry 2000, 276: 8014-8020. PMID: 11116150, DOI: 10.1074/jbc.m008845200.Peer-Reviewed Original ResearchConceptsGDP dissociation inhibitorDomain IIRab GDP dissociation inhibitorRab bindingRab localizationGenetic screenRab GTPasesTransport intermediatesDissociation inhibitorDeletion strainAcceptor membranesCytosolic poolVps21pVesicle fusionRabDomain IMutantsGdi1pYpt1pGeneral defectOrganellesCytosolMembraneDistinct subsetsSec4p