Chemical, biochemical, and structural similarities and differences of dermatological cAMP phosphodiesterase-IV inhibitors
Wang J, Ho M, Bunick C. Chemical, biochemical, and structural similarities and differences of dermatological cAMP phosphodiesterase-IV inhibitors. Journal Of Investigative Dermatology 2024 PMID: 39608668, DOI: 10.1016/j.jid.2024.10.597.Peer-Reviewed Original ResearchTreatment of psoriasisTopical treatmentAtopic dermatitisTopical treatment of atopic dermatitisIncreased cellular cAMP concentrationOral treatment of psoriasisPDE4 inhibitorsTopical treatment of psoriasisTreatment of atopic dermatitisCellular cAMP concentrationAnti-inflammatory effectsPhosphodiesterase-IV inhibitorImmune cellsOral treatmentPDE4 inhibitionSeborrheic dermatitisInflammatory responseCAMP concentrationAdenosine monophosphateRoflumilastDuration of cAMP signalingPDE4CAMP signalingDermatitisApremilast