2022
Standardization of presurgical language fMRI in Greek population: Mapping of six critical regions
Gkiatis K, Garganis K, Benjamin CF, Karanasiou I, Kondylidis N, Harushukuri J, Matsopoulos GK. Standardization of presurgical language fMRI in Greek population: Mapping of six critical regions. Brain And Behavior 2022, 12: e2609. PMID: 35587046, PMCID: PMC9226851, DOI: 10.1002/brb3.2609.Peer-Reviewed Original ResearchConceptsLanguage mappingFunctional magnetic resonance imagingPresurgical language mappingMother tongueLanguage systemWernicke-LichtheimLanguage regionsLanguage functional magnetic resonance imagingGreekLanguage lateralizationHealthy right-handed volunteersGreek populationRight-handed volunteersMagnetic resonance imagingClinical setupEloquent cortexFMRI acquisitionContralateral cerebellumPresurgical evaluationAppropriate tasksGreek patientsWada testResonance imagingNoninvasive alternativeFMRI protocol
2021
Cognitive Biomarkers in the Clinic: Lessons From Presurgical fMRI
Benjamin CFA. Cognitive Biomarkers in the Clinic: Lessons From Presurgical fMRI. Journal Of Clinical Neurophysiology 2021, 39: 121-128. PMID: 34366397, DOI: 10.1097/wnp.0000000000000834.Peer-Reviewed Original ResearchGerstmann Syndrome Deconstructed by Cortical Stimulation
Vaddiparti A, McGrath H, Benjamin C, Sivaraju A, Spencer DD, Hirsch LJ, Damisah E, Quraishi IH. Gerstmann Syndrome Deconstructed by Cortical Stimulation. Neurology 2021, 97: 420-422. PMID: 34187861, PMCID: PMC9246017, DOI: 10.1212/wnl.0000000000012441.Peer-Reviewed Original Research
2019
Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics
Langer N, Benjamin C, Becker BLC, Gaab N. Comorbidity of reading disabilities and ADHD: Structural and functional brain characteristics. Human Brain Mapping 2019, 40: 2677-2698. PMID: 30784139, PMCID: PMC6508987, DOI: 10.1002/hbm.24552.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional magnetic resonance imagingGroup differencesMultiple deficit modelFunctional brain characteristicsWhole-brain analysisOverall group differencesComprehensive behavioral testingCommon developmental disorderPhonological processingFMRI taskExecutive functionNeural correlatesHyperactivity disorderNeural mechanismsSame paradigmClinical groupsDevelopmental disordersDeficit modelBrain characteristicsBrain structuresInterest analysisBrain alterationsBehavioral testingChildren
2018
Presurgical language fMRI: Technical practices in epilepsy surgical planning
Benjamin CFA, Dhingra I, Li AX, Blumenfeld H, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen RA, Warfield SK, Peters JM, Reutens D, Połczyńska MM, Hirsch LJ, Spencer DD. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Human Brain Mapping 2018, 39: 4032-4042. PMID: 29962111, PMCID: PMC6175127, DOI: 10.1002/hbm.24229.Peer-Reviewed Original ResearchConceptsLanguage functional MRIFunctional MRISurgical planningEpilepsy surgical planningEpilepsy surgical programsGeneral linear modelingBlood flowClinical practicePatient careSurgical programsRoutine useMarked heterogeneityClinical applicationVerbal fluencyData highlightFMRI dataMost programsPatientsWidespread useEpilepsyIndividualsMRICarePresurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning
Benjamin CFA, Li AX, Blumenfeld H, Constable RT, Alkawadri R, Bickel S, Helmstaedter C, Meletti S, Bronen R, Warfield SK, Peters JM, Reutens D, Połczyńska M, Spencer DD, Hirsch LJ. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Human Brain Mapping 2018, 39: 2777-2785. PMID: 29528160, PMCID: PMC6033659, DOI: 10.1002/hbm.24039.Peer-Reviewed Original ResearchConceptsLanguage functional MRISurgical marginsFunctional MRIPatient outcomesClinical practiceEpilepsy surgical planningEpilepsy surgical programsCurrent clinical practiceDirect brain stimulationEpilepsy surgeryStimulation mappingBrain stimulationClinical teamLanguage lateralizationSurgical programsSurgical planningLanguage-critical areasFMRI findingsFMRI paradigmUnexpected preservationFurther validationLanguage declineAdultsOutcomesChildren
2017
Improving language mapping in clinical fMRI through assessment of grammar
Połczyńska M, Japardi K, Curtiss S, Moody T, Benjamin C, Cho A, Vigil C, Kuhn T, Jones M, Bookheimer S. Improving language mapping in clinical fMRI through assessment of grammar. NeuroImage Clinical 2017, 15: 415-427. PMID: 28616382, PMCID: PMC5458087, DOI: 10.1016/j.nicl.2017.05.021.Peer-Reviewed Original ResearchConceptsPre-operative fMRIIntraoperative cortical stimulationLeft hemisphereGood predictive valueHemisphere language dominanceLanguage-dominant hemisphereFunctional magnetic resonanceSurgical candidatesCortical stimulationFMRI testingBrain tumorsDominant hemisphereClinical fMRIPredictive valueBrain surgeryPatientsLanguage mappingStandard testsFMRI activationFMRI protocolFMRI testsRight hemisphereGrammar testRobust activationGroup levelPresurgical language fMRI: Mapping of six critical regions
Benjamin CF, Walshaw PD, Hale K, Gaillard WD, Baxter LC, Berl MM, Polczynska M, Noble S, Alkawadri R, Hirsch LJ, Constable RT, Bookheimer SY. Presurgical language fMRI: Mapping of six critical regions. Human Brain Mapping 2017, 38: 4239-4255. PMID: 28544168, PMCID: PMC5518223, DOI: 10.1002/hbm.23661.Peer-Reviewed Original ResearchConceptsLanguage lateralityWernicke's areaLanguage regionsBasal temporal language areaHum Brain MappTemporal language areaTumor patientsLanguage cortexIndependent cliniciansClinical fMRIExperienced cliniciansCliniciansLanguage mappingLanguage-critical areasSpeech areasAngular gyrusExner's areaLateralityFMRI taskBroca's areaBlind reviewNeurosurgical planningLanguage areasClinical neuropsychologistsFMRI data
2016
Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network
Połczyńska MM, Benjamin CF, Japardi K, Frew A, Bookheimer SY. Language system organization in a quadrilingual with a brain tumor: Implications for understanding of the language network. Neuropsychologia 2016, 86: 167-175. PMID: 27143224, DOI: 10.1016/j.neuropsychologia.2016.04.030.Peer-Reviewed Original ResearchConceptsLanguage mappingPre-operative functional magnetic resonance imagingLanguage-specific regionsFunctional magnetic resonance imagingAge of acquisitionIntraoperative language mappingAmount of exposureMultilingual speakersSecond languageFourth languageMultilingual individualsFrontal brain tumorLanguage similarityLanguage systemNeurocognitive modelsLanguageLanguage networkAge 5Different organizationsSpeakersMagnetic resonance imagingResonance imagingImpairmentSystem organizationOrganization
2014
Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases
Połczyńska MM, Benjamin CF, Moseley BD, Walshaw P, Eliashiv D, Vigil C, Jones M, Bookheimer SY. Role of the Wada test and functional magnetic resonance imaging in preoperative mapping of language and memory: two atypical cases. Neurocase 2014, 21: 707-720. PMID: 25372664, DOI: 10.1080/13554794.2014.977300.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonanceWada testAtypical language representationRight-handed individualsLanguage dominanceLanguage lateralizationLanguage representationCognitive deficitsUnexpected memoryWada testingAtypical casesMemoryResective epilepsy surgeryEpilepsy surgeryPreoperative mappingSeizure onsetInvasive proceduresMagnetic resonanceLateralizationDeficitsPotential riskRiskLanguageIndividualsSurgeryElemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy
Benjamin CF, Saling MM, Wood AG, Reutens DC. Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy. PLOS ONE 2014, 9: e100891. PMID: 24978828, PMCID: PMC4076213, DOI: 10.1371/journal.pone.0100891.Peer-Reviewed Original ResearchConceptsMTL damageAssociation formationAssociative processingTemporal lobe epilepsyMesial temporal lobe damageNovel fMRI taskCognitive neuropsychological modelGroup whole-brain analysesLeft Temporal Lobe EpilepsyMesial temporal lobeSimple visual stimuliTemporal lobe damageHigher cognitive functionsWhole-brain analysisReorganization of networksMore fundamental processesNeuropsychological modelFMRI taskMTL functionParahippocampal activationTypical adultsAssociative processesMTL structuresBehavioral performanceVisual stimuliBehavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians
Zuk J, Benjamin C, Kenyon A, Gaab N. Behavioral and Neural Correlates of Executive Functioning in Musicians and Non-Musicians. PLOS ONE 2014, 9: e99868. PMID: 24937544, PMCID: PMC4061064, DOI: 10.1371/journal.pone.0099868.Peer-Reviewed Original ResearchConceptsExecutive functionMusical trainingUntrained childrenEF skillsNeural correlatesVerbal fluencyConstruct of EFSMA/SMACognitive flexibilityEF batteryExecutive functioningAdult musiciansCognitive skillsCognitive capacityBrain activationRight VLPFCGreater activationProcessing speedAcademic achievementAcademic abilityRule representationEF regionFluencyMethodological limitationsMusicians
2013
The Neural Correlates of Reading Fluency Deficits in Children
Langer N, Benjamin C, Minas J, Gaab N. The Neural Correlates of Reading Fluency Deficits in Children. Cerebral Cortex 2013, 25: 1441-1453. PMID: 24335032, PMCID: PMC4428293, DOI: 10.1093/cercor/bht330.Peer-Reviewed Original ResearchConceptsReading-related tasksFusiform gyrusRD childrenFluent readingNeural correlatesIndividual reading speedReading networkTYP childrenFluency deficitsReading skillsReading performanceFMRI studyLess activationReading speedFluencyBrain regionsInterest analysisEducational practiceChildrenSuch dysfunctionTaskDeficitsCorrelatesReadingFMRI
2012
Optimization of tractography of the optic radiations
Benjamin CF, Singh JM, Prabhu SP, Warfield SK. Optimization of tractography of the optic radiations. Human Brain Mapping 2012, 35: 683-697. PMID: 23225566, PMCID: PMC4083652, DOI: 10.1002/hbm.22204.Peer-Reviewed Original Research
2011
What's the story? The tale of reading fluency told at speed
Benjamin CF, Gaab N. What's the story? The tale of reading fluency told at speed. Human Brain Mapping 2011, 33: 2572-2585. PMID: 21954000, PMCID: PMC3499039, DOI: 10.1002/hbm.21384.Peer-Reviewed Original ResearchConceptsFluent readingSentence readingReading speedNovel fMRI taskReading-related regionsRight-handed adultsPattern of activationFMRI taskFusiform cortexReading conditionMore recent conceptualizationsSingle wordsFluent sentencesMiddle temporalRecent conceptualizationsReaders processDiscrete skillsFluencyBrain regionsInterest analysisRegion responseReadingTaskSentencesWords
2010
Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy
Wood AG, Saling MM, Fedi M, Berkovic SF, Scheffer IE, Benjamin C, Reutens DC. Neuropsychological function in patients with a single gene mutation associated with autosomal dominant nocturnal frontal lobe epilepsy. Epilepsy & Behavior 2010, 17: 531-535. PMID: 20189461, DOI: 10.1016/j.yebeh.2010.01.168.Peer-Reviewed Original ResearchConceptsFrontal lobe functionAutosomal dominant nocturnal frontal lobe epilepsyCognitive flexibilityLobe functionEducation-matched control participantsCore cognitive deficitAspects of memoryFrontal lobe epilepsyVerbal memory impairmentNocturnal frontal lobe epilepsyLevel of impairmentIntellectual abilityNeuropsychological functionNeuropsychological phenotypeCognitive deficitsControl participantsMemory impairmentLobe epilepsyStandard clinical testsFocused measuresGroup of ageImpairmentTaskDisease-related factorsMemory
2007
Pre- and post-encephalitic neuropsychological profile of a 7-year-old girl
Benjamin C, Anderson V, Pinczower R, Leventer R, Richardson M, Nash M. Pre- and post-encephalitic neuropsychological profile of a 7-year-old girl. Neuropsychological Rehabilitation 2007, 17: 528-550. PMID: 17676533, DOI: 10.1080/09602010601130927.Peer-Reviewed Original ResearchConceptsNeuropsychological effectsDomains of personalityAttentional difficultiesExecutive functionNeuropsychological profileParietal damageNeuropsychological assessmentNon-HSV encephalitisDiffuse insultPremorbid functioningHerpes simplex virusBrain injurySpeechPervasive changesGirlsEmotionalityMemoryPersonalityPostinfectious encephalitisHSV encephalitisFunctioningFrontalPatient profilesSimplex virusDeficits
2005
Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy
Derry C, Benjamin C, Bladin P, le Bars D, Tochon-Danguy H, Berkovic SF, Zimmer L, Costes N, Mulligan R, Reutens D. Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy. NeuroImage 2005, 30: 341-348. PMID: 16275016, DOI: 10.1016/j.neuroimage.2005.09.052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBlood PressureBrainCentral Nervous System StimulantsFemaleHumansKineticsMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedNarcolepsyPiperazinesPolysomnographyPositron-Emission TomographyPyridinesRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReceptors, SerotoninSerotoninSleepConceptsSerotonin receptor availabilityReceptor availabilityMethylphenidate administrationSuppress REM sleepSprague-Dawley ratsPositron emission tomographyNarcoleptic humansNormal medicationEndogenous serotoninSerotonergic neurotransmissionREM sleepStimulant methylphenidatePET scansAnimal studiesHuman studiesWhole brainEmission tomographySleep scanPET studiesSleepWakefulnessHuman sleepScansT-testSignificant increase