2012
Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury
Won CH, Chun HJ, Chandra SM, Sarinas PS, Chitkara RK, Heidenreich PA. Severe obstructive sleep apnea increases mortality in patients with ischemic heart disease and myocardial injury. Sleep And Breathing 2012, 17: 85-91. PMID: 22294346, DOI: 10.1007/s11325-012-0653-y.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableBody Mass IndexCause of DeathCohort StudiesComorbidityContinuous Positive Airway PressureEchocardiographyFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPatient CompliancePolysomnographyPrognosisRiskRisk FactorsSleep Apnea, ObstructiveSurvival AnalysisTroponin IConceptsSevere obstructive sleep apneaObstructive sleep apneaIschemic heart diseaseSleep apneaMyocardial injuryHeart diseaseOSA groupMild-moderate obstructive sleep apneaModerate obstructive sleep apneaPrevious myocardial injuryAdjusted hazard ratioRetrospective cohort studyConsecutive OSA patientsElevated troponin levelsSevere OSA groupRisk of deathDose-dependent impactCohort studyHazard ratioOSA patientsOSA severityTroponin levelsConclusionsThe severityRisk stratificationCardiac patients
2010
Cardiovascular Consequences of Sleep Apnea
Selim B, Won C, Yaggi HK. Cardiovascular Consequences of Sleep Apnea. Clinics In Chest Medicine 2010, 31: 203-220. PMID: 20488282, DOI: 10.1016/j.ccm.2010.02.010.ChaptersConceptsObstructive sleep apneaCardiovascular diseaseSleep apneaTreatment of OSAImportant public health challengeNonfatal cardiovascular eventsSpecific cardiovascular outcomesSleep-disordered breathingCardiovascular health outcomesEpidemic of obesityBurden of diseaseCause of deathGeneral adult populationNovel therapeutic approachesPublic health challengeCardiovascular eventsCardiovascular outcomesCause mortalityCardiovascular consequencesMyocardial ischemiaTherapeutic approachesHealth outcomesAdult populationHealth challengesNovel target