2023
The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C. The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review. Sleep Medicine 2023, 108: 55-60. PMID: 37336060, DOI: 10.1016/j.sleep.2023.05.025.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive sleep apneaDefinition of COPDCPAP therapyOverlap syndromeSystematic reviewCOPD exacerbationsCPAP usageClinical outcomesContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureNewcastle-Ottawa Quality ScaleAirway pressure therapyPositive airway pressureObstructive pulmonary diseaseMeta-Analyses (PRISMA) statementPreferred Reporting ItemsComprehensive systematic reviewAirway pressurePulmonary diseaseSleep apneaPressure therapyPatient populationReporting ItemsInternational Consensus Statement on Obstructive Sleep Apnea
Chang JL, Goldberg AN, Alt JA, Mohammed A, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera J, Bartley B, Billings M, Boon M, Bosschieter P, Braverman I, Brodie K, Cabrera‐Muffly C, Caesar R, Cahali M, Cai Y, Cao M, Capasso R, Caples S, Chahine L, Chang C, Chang K, Chaudhary N, Cheong C, Chowdhuri S, Cistulli P, Claman D, Collen J, Coughlin K, Creamer J, Davis E, Dupuy‐McCauley K, Durr M, Dutt M, Ali M, Elkassabany N, Epstein L, Fiala J, Freedman N, Gill K, Gillespie M, Golisch L, Gooneratne N, Gottlieb D, Green K, Gulati A, Gurubhagavatula I, Hayward N, Hoff P, Hoffmann O, Holfinger S, Hsia J, Huntley C, Huoh K, Huyett P, Inala S, Ishman S, Jella T, Jobanputra A, Johnson A, Junna M, Kado J, Kaffenberger T, Kapur V, Kezirian E, Khan M, Kirsch D, Kominsky A, Kryger M, Krystal A, Kushida C, Kuzniar T, Lam D, Lettieri C, Lim D, Lin H, Liu S, MacKay S, Magalang U, Malhotra A, Mansukhani M, Maurer J, May A, Mitchell R, Mokhlesi B, Mullins A, Nada E, Naik S, Nokes B, Olson M, Pack A, Pang E, Pang K, Patil S, Van de Perck E, Piccirillo J, Pien G, Piper A, Plawecki A, Quigg M, Ravesloot M, Redline S, Rotenberg B, Ryden A, Sarmiento K, Sbeih F, Schell A, Schmickl C, Schotland H, Schwab R, Seo J, Shah N, Shelgikar A, Shochat I, Soose R, Steele T, Stephens E, Stepnowsky C, Strohl K, Sutherland K, Suurna M, Thaler E, Thapa S, Vanderveken O, de Vries N, Weaver E, Weir I, Wolfe L, Woodson B, Won C, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu J, Zeidler M, Rosen I. International Consensus Statement on Obstructive Sleep Apnea. International Forum Of Allergy & Rhinology 2023, 13: 1061-1482. PMID: 36068685, PMCID: PMC10359192, DOI: 10.1002/alr.23079.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaEvidence-based reviewPositive airway pressureInternational consensus statementSleep apneaConsensus statementAdult OSA patientsMultiple treatment modalitiesSleep apnea evaluationAirway pressureOSA patientsPAP adherenceSurgical treatmentEvidence-based practiceOSA treatmentLongitudinal careTreatment modalitiesClinical managementRisk factorsHealth risk outcomesStudy qualitySyndrome definitionCurrent evidenceRecommendation formatOSA disease
2021
Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era
Wang SY, Juthani PV, Borges KA, Shallow MK, Gupta A, Price C, Won CH, Chun HJ. Severe breakthrough COVID-19 cases in the SARS-CoV-2 delta (B.1.617.2) variant era. The Lancet Microbe 2021, 3: e4-e5. PMID: 34901896, PMCID: PMC8641954, DOI: 10.1016/s2666-5247(21)00306-2.Peer-Reviewed Original ResearchHospitalisation among vaccine breakthrough COVID-19 infections
Juthani PV, Gupta A, Borges KA, Price CC, Lee AI, Won CH, Chun HJ. Hospitalisation among vaccine breakthrough COVID-19 infections. The Lancet Infectious Diseases 2021, 21: 1485-1486. PMID: 34506735, PMCID: PMC8423430, DOI: 10.1016/s1473-3099(21)00558-2.Peer-Reviewed Original ResearchImpact of Sex on Sleep Disorders Across the Lifespan
Tobias L, Thapa S, Won CHJ. Impact of Sex on Sleep Disorders Across the Lifespan. Clinics In Chest Medicine 2021, 42: 427-442. PMID: 34353449, DOI: 10.1016/j.ccm.2021.04.005.ChaptersConceptsSleep disordersAdverse maternal outcomesSleep-disordered breathingQuality of lifeImpact of sexDevelopment of insomniaMaternal outcomesMedical comorbiditiesSex predominanceVasomotor symptomsSleep symptomsReproductive milestonesSleep disturbancesSleep architectureSleep disruptionHormonal changesWomen's livesDisordersMenopausePregnancySymptomsComorbiditiesDerangementInsomniaPrevalenceOptimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society
Mokhlesi B, Won CH, Make BJ, Selim BJ, Sunwoo BY, Panel O, Gay P, Owens R, Wolfe L, Benditt J, Aboussouan L, Coleman J, Hess D, Hill N, Criner G, Branson R, Celli B, MacIntyre N, Sergew A, Morgenthaler T, Malhotra A, Berry R, Johnson K, Raphaelson M, Mokhlesi B, Won C, Selim B, Make B, Sunwoo B, Collop N, Patil S, Chediak A, Olson E, Vohra K. Optimal NIV Medicare Access Promotion: Patients With Hypoventilation Syndromes A Technical Expert Panel Report From the American College of Chest Physicians, the American Association for Respiratory Care, the American Academy of Sleep Medicine, and the American Thoracic Society. CHEST Journal 2021, 160: e377-e387. PMID: 34339686, PMCID: PMC8628178, DOI: 10.1016/j.chest.2021.06.083.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBilevel positive airway pressureArterial blood gasesHypoventilation syndromeNoninvasive ventilationBlood gasesNIV therapySleep studiesHome NIV therapyObesity hypoventilation syndromePositive airway pressureClinical practice guidelinesTime of dischargeVenous blood gasesAmerican Thoracic SocietyHome noninvasive ventilationExpert Panel ReportTechnical expert panelMedicare beneficiaries' accessSustained hypoxemiaAirway pressureChest PhysiciansTrial evidenceRespiratory careThoracic SocietyPractice guidelinesThe use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update.
Shamim-Uzzaman QA, Bae CJ, Ehsan Z, Setty AR, Devine M, Dhankikar S, Donskoy I, Fields B, Hearn H, Hwang D, Jain V, Kelley D, Kirsch DB, Martin W, Troester M, Trotti LM, Won CH, Epstein LJ. The use of telemedicine for the diagnosis and treatment of sleep disorders: an American Academy of Sleep Medicine update. Journal Of Clinical Sleep Medicine 2021, 17: 1103-1107. PMID: 33599202, PMCID: PMC8320493, DOI: 10.5664/jcsm.9194.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIdentification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey
Berezin L, Nagappa M, Wong J, Clivatti J, Singh M, Auckley D, Charchaflieh JG, Fagerlund M, Gali B, Joshi GP, Overdyk FJ, Margarson M, Mokhlesi B, Moon T, Ramachandran SK, Ryan CM, Schumann R, Weingarten TN, Won CHJ, Chung F. Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey. Anesthesia & Analgesia 2021, 132: 1223-1230. PMID: 33857964, DOI: 10.1213/ane.0000000000005446.Peer-Reviewed Original ResearchMeSH KeywordsAnesthesiaAnesthesiologistsAnesthesiologyClinical CompetenceConsensusCross-Sectional StudiesCurriculumDelphi TechniqueEducation, Medical, GraduateFemaleHumansInternship and ResidencyMalePostoperative ComplicationsProspective StudiesRisk AssessmentRisk FactorsSleep Apnea SyndromesSleep Medicine SpecialtySurgical Procedures, OperativeConceptsSleep medicineSleep disordersMedicine topicsProspective cross-sectional surveyUpper airway obstructionAdverse perioperative eventsUpper airway patencyInfluence of opioidsControl of breathingCross-sectional surveyDelphi technique surveyEffects of sleepPractice of anesthesiologyAirway obstructionAirway patencyAnesthetic managementPerioperative eventsAnesthetic implicationsSleep apneaHypnotic medicationsField of anesthesiaAnesthetic agentsGeneral populationAnesthesiaAnesthesia residencyA neutrophil activation signature predicts critical illness and mortality in COVID-19
Meizlish ML, Pine AB, Bishai JD, Goshua G, Nadelmann ER, Simonov M, Chang CH, Zhang H, Shallow M, Bahel P, Owusu K, Yamamoto Y, Arora T, Atri DS, Patel A, Gbyli R, Kwan J, Won CH, Dela Cruz C, Price C, Koff J, King BA, Rinder HM, Wilson FP, Hwa J, Halene S, Damsky W, van Dijk D, Lee AI, Chun HJ. A neutrophil activation signature predicts critical illness and mortality in COVID-19. Blood Advances 2021, 5: 1164-1177. PMID: 33635335, PMCID: PMC7908851, DOI: 10.1182/bloodadvances.2020003568.Peer-Reviewed Original ResearchConceptsCritical illnessHealth system databaseNeutrophil activationCOVID-19Neutrophil activation signatureSevere COVID-19Intensive care unitGranulocyte colony-stimulating factorHigh mortality rateColony-stimulating factorSystem databaseHepatocyte growth factorClinical decompensationNeutrophil countImmune hyperactivationCare unitEarly elevationLipocalin-2Interleukin-8Longitudinal cohortClinical dataMortality ratePatientsIllnessActivation signature
2019
Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis
Won C, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep 2019, 43: zsz274. PMID: 31687772, PMCID: PMC7215264, DOI: 10.1093/sleep/zsz274.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexObstructive sleep apneaMulti-Ethnic StudyArousal criteriaObstructive sleep apnea phenotypesSex differencesLow arousal thresholdRelative sex differencesApnea phenotypesNREM-AHIPathophysiological endotypesREM-OSAAirway collapsibilityOSA prevalenceSleep apneaDesaturation criteriaEndotypesSex disparitiesArousal thresholdPolysomnography dataSignificant sex differencesREM eventsWomenLow loop gainNREM
2018
Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease.
Won CHJ, Qin L, Selim B, Yaggi HK. Varying Hypopnea Definitions Affect Obstructive Sleep Apnea Severity Classification and Association With Cardiovascular Disease. Journal Of Clinical Sleep Medicine 2018, 14: 1987-1994. PMID: 30518445, PMCID: PMC6287733, DOI: 10.5664/jcsm.7520.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHypopnea definitionsDesaturation criteriaOdds ratioCardiovascular diseaseOSA diagnosisSeverity of OSAModerate obstructive sleep apneaSevere obstructive sleep apneaDifferent hypopnea definitionsLess smoking historySleep-disordered breathingIschemic heart diseaseSignificant risk factorsCross-sectional analysisArousal definitionHypopnea criteriaCardiovascular riskOSA severitySmoking historyHeart failureClinical featuresSleep apneaOSA groupRisk factorsDiagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease
Bravata DM, Sico J, Fragoso C, Miech EJ, Matthias MS, Lampert R, Williams LS, Concato J, Ivan CS, Fleck JD, Tobias L, Austin C, Ferguson J, Radulescu R, Iannone L, Ofner S, Taylor S, Qin L, Won C, Yaggi HK. Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease. Journal Of The American Heart Association 2018, 7: e008841. PMID: 30369321, PMCID: PMC6201384, DOI: 10.1161/jaha.118.008841.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure usePositive airway pressure useTransient ischemic attackRankin Scale scoreIschemic stroke/transient ischemic attackStroke/transient ischemic attackBackground Obstructive sleep apneaHealth Stroke ScaleIschemic attackScale scoreStroke ScaleIschemic strokeTreat analysisSleep apneaAcute ischemic stroke/transient ischemic attackHealth Stroke Scale scoreNational InstituteContinuous positive airway pressureModified Rankin Scale scoreNeurological functioningNeurological symptom severityRecent ischemic strokeStroke Scale scoreAcute cerebrovascular diseaseAcute ischemic strokeSleep in Women Across the Life Span
Pengo M, Won C, Bourjeily G. Sleep in Women Across the Life Span. CHEST Journal 2018, 154: 196-206. PMID: 29679598, PMCID: PMC6045782, DOI: 10.1016/j.chest.2018.04.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSleep disturbancesSleep disordersSleep deprivationRestless legs syndromePoor sleep qualityParticular health outcomesLegs syndromeSex hormonesSleep changesNeonatal lifePoor sleepHormonal changesSleep qualitySleep pathologyHealth outcomesSleep regulationSleep conditionsFemale subjectsSleep challengesUnderstanding of sleepSleepWomenMenopauseDisordersOutcomes
2017
Man Versus Machine.
Won CH. Man Versus Machine. Journal Of Clinical Sleep Medicine 2017, 13: 167-168. PMID: 28095981, PMCID: PMC5263070, DOI: 10.5664/jcsm.6436.Commentaries, Editorials and LettersHumansSleep Apnea, Obstructive
2016
The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study.
Selim BJ, Koo BB, Qin L, Jeon S, Won C, Redeker NS, Lampert RJ, Concato JP, Bravata DM, Ferguson J, Strohl K, Bennett A, Zinchuk A, Yaggi HK. The Association between Nocturnal Cardiac Arrhythmias and Sleep-Disordered Breathing: The DREAM Study. Journal Of Clinical Sleep Medicine 2016, 12: 829-37. PMID: 26951420, PMCID: PMC4877315, DOI: 10.5664/jcsm.5880.Peer-Reviewed Original ResearchConceptsSleep-disordered breathingNocturnal cardiac arrhythmiasIntraventricular conduction delayApnea-hypopnea indexCardiac arrhythmiasTwo-fold oddsModerate-severe sleep-disordered breathingSeverity of SDBSevere sleep-disordered breathingComplex ventricular ectopyMultiple cardiovascular comorbiditiesObstructive respiratory eventsClinic-based populationCross-sectional analysisCardiovascular comorbiditiesSDB patientsVentricular ectopySDB severityRespiratory eventsUnadjusted oddsSupraventricular tachycardiaCardiovascular diseaseArrhythmia subtypesArrhythmia riskConduction delayThe use of positive airway pressure therapy for treatment of resistant hypertension
Won C, Guilleminault C. The use of positive airway pressure therapy for treatment of resistant hypertension. Expert Review Of Cardiovascular Therapy 2016, 14: 505-511. PMID: 26671301, DOI: 10.1586/14779072.2016.1132626.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressure therapyObstructive sleep apneaAirway pressure therapyBlood pressure controlResistant hypertensionPressure therapyPressure controlSubgroup of patientsHigh-risk populationBlood pressureSleep apneaRisk factorsPathological mechanismsHypertensionNovel targetPatientsTherapyPotential mechanismsApneaMedicationsBreathingSleepTrials
2015
The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods
Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Zinchuk AV, Yaggi HK. The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods. Sleep And Breathing 2015, 20: 893-900. PMID: 26642771, DOI: 10.1007/s11325-015-1254-3.Peer-Reviewed Original ResearchConceptsCardiovascular outcomesVascular eventsSleep architecturePrognostic modelRetrospective observational cohort studyMain primary outcomeMiddle-aged veteransTransient ischemic attackAcute coronary syndromeObservational cohort studyResultsThe study populationCongestive heart failureSleep-disordered breathingVA Patient Treatment FileVital Status filesPatient Treatment FileComputerized patient record systemVeterans Affairs centersPost-traumatic stress disorderIschemic attackCoronary syndromeCohort studySecondary outcomesComposite endpointGlycemic controlSleeping for Two: The Great Paradox of Sleep in Pregnancy.
Won CH. Sleeping for Two: The Great Paradox of Sleep in Pregnancy. Journal Of Clinical Sleep Medicine 2015, 11: 593-4. PMID: 25979097, PMCID: PMC4442217, DOI: 10.5664/jcsm.4760.Commentaries, Editorials and LettersGender differences in sleep disordered breathing: implications for therapy
Won C, Guilleminault C. Gender differences in sleep disordered breathing: implications for therapy. Expert Review Of Respiratory Medicine 2015, 9: 221-231. PMID: 25739831, DOI: 10.1586/17476348.2015.1019478.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep-disordered breathingSeverity of OSAUpper airway functionGender-related differencesAirway functionEndothelial dysfunctionLung functionComorbid conditionsSleep apneaTreatment optionsRespiratory stabilityImproved outcomesGender differencesGreater riskAdverse effectsWomenLimited dataAge increasesBreathingFemale presentationsHypertensionApneaAirwayPregnancy
2014
Sleep in Patients with Restrictive Lung Disease
Won CH, Kryger M. Sleep in Patients with Restrictive Lung Disease. Clinics In Chest Medicine 2014, 35: 505-512. PMID: 25156766, DOI: 10.1016/j.ccm.2014.06.006.ChaptersConceptsRestrictive lung diseaseLung diseaseObesity hypoventilation syndromeInterstitial lung diseasePathophysiology of sleepImpact of treatmentOverall prognosisVentilatory defectHypoventilation syndromeImpaired ventilationDaytime fatigueSleep disruptionRelated symptomsSleep disordersSleep qualityDiffusion impairmentNeuromuscular diseaseDiseasePatientsPathophysiologySleepHypoxemiaHypercarbiaPrognosisDysfunction