2023
Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinence
2021
Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance users
2020
Measurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder
Haeny AM, Kiluk BD, Nich C, LaPaglia DM, Carroll KM. Measurement invariance of the Barratt Impulsiveness Scale across black and white adults with cocaine use disorder. Addictive Behaviors 2020, 114: 106721. PMID: 33162231, PMCID: PMC7802511, DOI: 10.1016/j.addbeh.2020.106721.Peer-Reviewed Original ResearchConceptsBarratt Impulsiveness ScaleHigher motor impulsivenessCocaine use disorderMeasurement invarianceMotor impulsivenessImpulsiveness ScaleBlack subsampleUse disordersDays abstinentMulti-group confirmatory factor analysisTreatment retentionCocaine abuse/dependenceCocaine treatment outcomesFactor analysisConfirmatory factor analysisAbuse/dependenceImpulsivityCocaine-negative urinesImpulsivenessBivariate correlationsWhite subsampleAbstinentOverall sampleTotal sampleAdults
2019
Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder
Roos CR, Nich C, Mun CJ, Babuscio TA, Mendonca J, Miguel AQC, DeVito EE, Yip SW, Witkiewitz K, Carroll KM, Kiluk BD. Clinical validation of reduction in cocaine frequency level as an endpoint in clinical trials for cocaine use disorder. Drug And Alcohol Dependence 2019, 205: 107648. PMID: 31677490, PMCID: PMC6910212, DOI: 10.1016/j.drugalcdep.2019.107648.Peer-Reviewed Original ResearchPatterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning.
Roos CR, Nich C, Mun CJ, Mendonca J, Babuscio TA, Witkiewitz K, Carroll KM, Kiluk BD. Patterns of Cocaine Use During Treatment: Associations With Baseline Characteristics and Follow-Up Functioning. Journal Of Studies On Alcohol And Drugs 2019, 80: 431-440. PMID: 31495380, PMCID: PMC6739643, DOI: 10.15288/jsad.2019.80.431.Peer-Reviewed Original Research
2017
Initial validation of a proxy indicator of functioning as a potential tool for establishing a clinically meaningful cocaine use outcome
Kiluk BD, Babuscio TA, Nich C, Carroll KM. Initial validation of a proxy indicator of functioning as a potential tool for establishing a clinically meaningful cocaine use outcome. Drug And Alcohol Dependence 2017, 179: 400-407. PMID: 28858744, PMCID: PMC5611843, DOI: 10.1016/j.drugalcdep.2017.07.020.Peer-Reviewed Original Research
2014
What Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up
Kiluk BD, Nich C, Witkiewitz K, Babuscio TA, Carroll KM. What Happens in Treatment Doesn’t Stay in Treatment: Cocaine Abstinence During Treatment Is Associated With Fewer Problems at Follow-Up. Journal Of Consulting And Clinical Psychology 2014, 82: 619-627. PMID: 24635550, PMCID: PMC4115028, DOI: 10.1037/a0036245.Peer-Reviewed Original ResearchAssessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials
Decker SE, Frankforter T, Babuscio T, Nich C, Ball SA, Carroll KM. Assessment concordance and predictive validity of self‐report and biological assay of cocaine use in treatment trials. American Journal On Addictions 2014, 23: 466-474. PMID: 24628970, PMCID: PMC4139466, DOI: 10.1111/j.1521-0391.2014.12132.x.Peer-Reviewed Original ResearchConceptsPredictive validityPsychosocial outcomesCocaine useSelf-report assessmentsSelf-report accuracyCocaine treatment trialSelf-reported dataPost-treatment pointSelf-reported cocaine useMethod variancePost-treatment outcomesTreatment trialsTreatment completionAssessment methodsUrinalysis resultsValidityRandomized clinical trials
2013
Smokers Versus Snorters: Do Treatment Outcomes Differ According to Route of Cocaine Administration?
Kiluk BD, Babuscio TA, Nich C, Carroll KM. Smokers Versus Snorters: Do Treatment Outcomes Differ According to Route of Cocaine Administration? Experimental And Clinical Psychopharmacology 2013, 21: 490-498. PMID: 24364538, PMCID: PMC3943602, DOI: 10.1037/a0034173.Peer-Reviewed Original ResearchConceptsTreatment outcomesCocaine administrationAddiction Severity Index composite scoresIntranasal usersComposite scoreRoute of administrationCocaine use outcomesPrimary routeIntranasal routeClinical trialsSustained abstinenceCocaine-dependent individualsTreatment phaseSmokersCocaine useStudy periodAdministrationUse outcomesSeverity of problemsMaximal concentrationStatistical significanceASI domainsOutcomesDifferential changesCocaine
1998
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts
Petrakis I, Carroll K, Nich C, Gordon L, Kosten T, Rounsaville B. Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. Drug And Alcohol Dependence 1998, 50: 221-226. PMID: 9649975, DOI: 10.1016/s0376-8716(98)00032-5.Peer-Reviewed Original ResearchConceptsCocaine useOpioid addictsMedication effectsDepressive symptomsSignificant decreaseEffectiveness of fluoxetineSelf-reported cocaine useDrug use outcomesSubsample of subjectsFluoxetine treatmentUrine toxicologySelf-reported useDepressive disorderSevere depressionHeroin useFluoxetineEffective agentUse outcomesDepressionPlaceboSignificant differencesTreatmentSymptomsAddictsMethadoneTreatment of cocaine and alcohol dependence with psychotherapy and disulfiram
Carroll KM, Nich C, Ball SA, McCance E, Rounsavile BJ. Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram. Addiction 1998, 93: 713-727. PMID: 9692270, DOI: 10.1046/j.1360-0443.1998.9357137.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentAlcohol useClinical managementCocaine useConcurrent alcohol abuseDrug use disordersTreatment of cocaineCo-morbid disordersPromising treatment strategySubstance abuse treatment centersTreatment-seeking cocaine abusersUrine toxicologyDrug-dependent individualsContinuous abstinenceDisulfiram treatmentStep FacilitationTreatment strategiesCocaine-dependent individualsAlcohol abuseAlcohol abusersUse disordersTreatment centersSupportive psychotherapyAlcohol dependenceActive psychotherapy
1997
Contribution of the Therapeutic Alliance to Outcome in Active Versus Control Psychotherapies
Carroll K, Nich C, Rounsaville B. Contribution of the Therapeutic Alliance to Outcome in Active Versus Control Psychotherapies. Journal Of Consulting And Clinical Psychology 1997, 65: 510-514. PMID: 9170775, DOI: 10.1037/0022-006x.65.3.510.Peer-Reviewed Original ResearchNow You See It, Now You Don't: A Comparison of Traditional Versus Random-Effects Regression Models in the Analysis of Longitudinal Follow-Up Data From a Clinical Trial
Nich C, Carroll K. Now You See It, Now You Don't: A Comparison of Traditional Versus Random-Effects Regression Models in the Analysis of Longitudinal Follow-Up Data From a Clinical Trial. Journal Of Consulting And Clinical Psychology 1997, 65: 252-261. PMID: 9086688, DOI: 10.1037/0022-006x.65.2.252.Peer-Reviewed Original ResearchVariability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials.
Carroll KM, Nich C, Rounsaville BJ. Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials. NIDA Research Monograph 1997, 175: 137-57. PMID: 9467796.Peer-Reviewed Original ResearchConceptsPatient-treatment interactionsTreatment responseCocaine abusersClinical pharmacotherapy trialsChallenging patient populationEffective pharmacological interventionsStudy sampleSpecific treatment strategiesTreatment-seeking cocaine abusersPatient populationPharmacotherapy trialsMedication effectsNew medicationsPharmacologic agentsTreatment responsivenessPharmacological interventionsPharmacotherapy researchTreatment strategiesLarger sample sizeCocaine dependenceComparison of findingsTreatment seekingStandardized assessmentSimple main effectsInconsistent findings
1995
Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy
CARROLL K, NICH C, ROUNSAVILLE B. Differential Symptom Reduction in Depressed Cocaine Abusers Treated with Psychotherapy and Pharmacotherapy. The Journal Of Nervous And Mental Disease 1995, 183: 251-259. PMID: 7714514, DOI: 10.1097/00005053-199504000-00012.Peer-Reviewed Original ResearchConceptsDepressive symptomsSymptom reductionCocaine abusersTrial of desipramineRelapse prevention treatmentSupportive clinical managementGreater reductionEuthymic subgroupPsychotherapy conditionsDesipramine treatmentEffective antidepressantDepressed subgroupClinical managementCognitive-behavioral treatmentTreatment responsePrevention treatmentCocaine outcomesAmbulatory cocaine abusersDepressive symptomatologyCocaine useCocaine addictsConsecutive abstinenceIntegrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial.
Carroll KM, Rounsaville BJ, Nich C, Gordon L, Gawin F. Integrating psychotherapy and pharmacotherapy for cocaine dependence: results from a randomized clinical trial. NIDA Research Monograph 1995, 150: 19-35. PMID: 8742770.Peer-Reviewed Original Research
1994
One-Year Follow-up of Psychotherapy and Pharmacotherapy for Cocaine Dependence: Delayed Emergence of Psychotherapy Effects
Carroll KM, Rounsaville BJ, Nich C, Gordon LT, Wirtz PW, Gawin F. One-Year Follow-up of Psychotherapy and Pharmacotherapy for Cocaine Dependence: Delayed Emergence of Psychotherapy Effects. JAMA Psychiatry 1994, 51: 989-997. PMID: 7979888, DOI: 10.1001/archpsyc.1994.03950120061010.Peer-Reviewed Original ResearchConceptsCognitive-behavioral relapse preventionRelapse preventionAmbulatory cocaine abusersCocaine dependenceSupportive clinical managementCoping skillsCocaine usePsychotherapy effectsLess cocaine useSubstance abusersPsychotherapyFull sampleCocaine abusersEffects regression modelsRandom effects regression modelsAbusersOutpatient treatmentOne-year followPosttreatment levelsSubject implementationTime effectsPharmacotherapySkillsAbstinenceRelative abilityBlind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial
Carroll K, Rounsaville B, Nich C. Blind Man’s Bluff: Effectiveness and Significance of Psychotherapy and Pharmacotherapy Blinding Procedures in a Clinical Trial. Journal Of Consulting And Clinical Psychology 1994, 62: 276-280. PMID: 8201064, DOI: 10.1037/0022-006x.62.2.276.Peer-Reviewed Original ResearchPsychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll KM, Rounsaville BJ, Gordon LT, Nich C, Jatlow P, Bisighini RM, Gawin FH. Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers. JAMA Psychiatry 1994, 51: 177-187. PMID: 8122955, DOI: 10.1001/archpsyc.1994.03950030013002.Peer-Reviewed Original ResearchConceptsClinical managementCocaine useCocaine abusersRelapse preventionAmbulatory cocaine abusersWeeks of treatmentForm of treatmentHigh-severity patientsInitiation trialsAbstinence initiationBaseline severityClinical trialsEffective treatmentTreatment retentionBetter outcomesCocaine abusePharmacotherapyDepressed subjectsPlaceboDesipramine hydrochlorideSpecialized treatmentDesipraminePreventionGreater reductionDistinct subgroups