2018
Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis
Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.Peer-Reviewed Original ResearchConceptsRestless legs syndromePrevalence of RLSConcurrent restless legs syndromePeriodic limb movementsMulti-Ethnic StudyLegs syndromeObesity statusOdds of RLSLimb movementsPrevalence of PLMSCommunity-based sampleRace/ethnicityRLS symptomsClinical criteriaAdjusted modelPLMSStudy participantsPrevalenceOlder individualsCross-sectional dataAtherosclerosisSexSyndromeWhite participantsSleep
2016
Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance
Ferri R, Koo BB, Picchietti DL, Fulda S. Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Medicine 2016, 31: 29-38. PMID: 28341521, DOI: 10.1016/j.sleep.2016.05.014.Peer-Reviewed Original ResearchConceptsRestless legs syndromePeriodic leg movementsLeg movementsLeg motor activityLegs syndromePathophysiological correlatesClinical correlatesObjective findingsClinical significanceClinical conditionsNeurophysiologic aspectsCurrent evidencePLMSMotor phenomenaMotor activityAge groupsTypical phenotypeSleepRecent findingsCurrent knowledgeFurther researchCorrelatesFindingsPhenotypeScoringRestless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency
2011
Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men
Koo BB, Blackwell T, Ancoli-Israel S, Stone KL, Stefanick ML, Redline S, Group F. Association of Incident Cardiovascular Disease With Periodic Limb Movements During Sleep in Older Men. Circulation 2011, 124: 1223-1231. PMID: 21859975, PMCID: PMC3265562, DOI: 10.1161/circulationaha.111.038968.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiovascular DiseasesCohort StudiesFollow-Up StudiesHumansIncidenceMaleNocturnal Myoclonus SyndromePolysomnographySleepSleep Wake DisordersTreatment OutcomeConceptsCause cardiovascular diseaseCoronary heart diseasePeripheral arterial diseaseIncident cardiovascular diseasePeriodic limb movementsArterial diseaseCardiovascular diseaseCerebrovascular diseaseHeart diseasePLMS frequencyRelative hazardCommunity-dwelling elderly menConventional cardiovascular risk factorsPeripheral arterial disease eventsLimb movementsElderly male cohortCardiovascular risk factorsBody mass indexProportional hazards regressionRisk of incidentPrevalent hypertensionCardiovascular riskMass indexStudy cohortHazards regression