Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs
Seidel C, Zhernovkov V, Cassidy H, Kholodenko B, Matallanas D, Cosnier F, Gaté L. Inhaled multi-walled carbon nanotubes differently modulate global gene and protein expression in rat lungs. Nanotoxicology 2020, 15: 238-256. PMID: 33332178, DOI: 10.1080/17435390.2020.1851418.Peer-Reviewed Original ResearchConceptsNM-401Bronchoalveolar lavage fluidLong-term health effectsWeeks of inhalationDose-dependent increasePost-exposure timeLung inflammationLavage fluidWhole lungRat lungInhalationHealth effectsProtein expressionRecovery periodMechanisms of toxicityMWCNT exposureDifferent toxicological profilesLungToxicological profileDaysToxicological effectsPersistent effectsToxicityAnimalsToxicogenomic approachAcute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease
Hadrup N, Zhernovkov V, Jacobsen N, Voss C, Strunz M, Ansari M, Schiller H, Halappanavar S, Poulsen S, Kholodenko B, Stoeger T, Saber A, Vogel U. Acute Phase Response as a Biological Mechanism‐of‐Action of (Nano)particle‐Induced Cardiovascular Disease. Small 2020, 16: e1907476. PMID: 32227434, DOI: 10.1002/smll.201907476.Peer-Reviewed Original ResearchConceptsAcute phase responseCardiovascular diseaseInduced Cardiovascular DiseasePhase responseInhalation of particlesLung cancerLung depositionImportant scientific evidenceOccupational diseasesDiseaseScientific evidencePotential health hazardsBiological mechanismsHealth hazardsRiskResponseImportant mechanismHigh levelsRisk assessmentCausal relationshipInhalationCancer