2001
Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria.
Demin O, Gorianin I, Kholodenko B, Westerhoff H. Kinetic modeling of energy metabolism and generation of active forms of oxygen in hepatocyte mitochondria. Молекулярная Биология 2001, 35: 1095-104. PMID: 11771135.Peer-Reviewed Original Research
1998
Subtleties in control by metabolic channelling and enzyme organization
Kholodenko B, Rohwer J, Cascante M, Westerhoff H. Subtleties in control by metabolic channelling and enzyme organization. Molecular And Cellular Biochemistry 1998, 184: 311-320. PMID: 9746327, DOI: 10.1023/a:1006809028612.Peer-Reviewed Original ResearchConceptsPhosphotransferase systemMetabolic control analysisBacterial phosphotransferase systemEnzyme-enzyme associationsDirect metabolite transferEnzyme organizationConcomitant phosphorylationTernary complex formationPTS pathwayMetabolite transferEnzyme sequestrationMetabolic channellingLiving cellsMacromolecular crowdingPhosphoryl groupEnzyme controlTernary complexCell functionPathwayEnzymeComplex formationIdeal systemEnzyme control coefficientsMetabolic systemsControl coefficients
1995
Energy, control and DNA structure in the living cell
Wijker J, Jensen P, Snoep J, Gomes A, Guiral M, Jongsma A, de Waal A, Hoving S, van Dooren S, van der Weijden C, van Workum M, van Heeswijk W, Molenaar O, Wielinga P, Richard P, Diderich J, Bakker B, Teusink B, Hemker M, Rohwer J, van der Gugten A, Kholodenko B, Westerhoff H. Energy, control and DNA structure in the living cell. Biophysical Chemistry 1995, 55: 153-165. PMID: 7632875, DOI: 10.1016/0301-4622(94)00148-d.Peer-Reviewed Original ResearchConceptsHigh ATP/ADP ratiosATP/ADP ratioCell physiologyADP ratioCertain cell typesCellular functionsIntracellular ATP levelsTransduction pathwaysDNA structureLiving cellsCell typesIon gradientsHomeostatic control mechanismsATP levelsCell functionElaborate controlPhysiologyCellsControl mechanismsMaintenanceControl theory of metabolic channelling
Kholodenko B, Cascante M, Westerhoff H. Control theory of metabolic channelling. Molecular And Cellular Biochemistry 1995, 143: 151-168. PMID: 7596350, DOI: 10.1007/bf01816949.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnergy MetabolismEnzymesHumansMathematicsModels, BiologicalOxidative PhosphorylationSignal TransductionThermodynamicsConceptsControl theory
1994
Control theory of metabolic channelling
Kholodenko B, Cascante M, Westerhoff H. Control theory of metabolic channelling. Molecular And Cellular Biochemistry 1994, 133-134: 313-331. PMID: 7808462, DOI: 10.1007/bf01267963.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEnergy MetabolismHumansMitochondria, MuscleModels, BiologicalMusclesPhosphatesSignal TransductionThermodynamicsConceptsControl theory
1985
Role of the 2,3-diphosphoglycerate shunt in regulating energy metabolism in human erythrocytes.
Kholodenko B, Stepanchikova A, Erlikh L, Ataullakhanov F, Zhabotinskiĭ A. Role of the 2,3-diphosphoglycerate shunt in regulating energy metabolism in human erythrocytes. Bulletin Of The Russian Academy Of Sciences. Biological Series 1985, 196-205. PMID: 3157714.Peer-Reviewed Original Research
1981
Regulation of erythrocyte energy metabolism. Dependence of glycolysis characteristics on donor individual parameters.
Kholodenko B, Dibrov B, Zhabotinskiĭ A. Regulation of erythrocyte energy metabolism. Dependence of glycolysis characteristics on donor individual parameters. Биофизика 1981, 26: 501-6. PMID: 6455164.Peer-Reviewed Original ResearchRegulation of glycolysis in human erythrocytes. The mechanism of ATP concentration stabilization.
Ataullakhanov F, Vitvitsky V, Zhabotinsky A, Pichugin A, Kholodenko B, Ehrlich L. Regulation of glycolysis in human erythrocytes. The mechanism of ATP concentration stabilization. Acta Biologica Et Medica Germanica 1981, 40: 991-7. PMID: 7331640.Peer-Reviewed Original Research