Featured Publications
Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
Bolado-Carrancio A, Rukhlenko O, Nikonova E, Tsyganov M, Wheeler A, Garcia-Munoz A, Kolch W, von Kriegsheim A, Kholodenko B. Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration. ELife 2020, 9: e58165. PMID: 32705984, PMCID: PMC7380942, DOI: 10.7554/elife.58165.Peer-Reviewed Original ResearchCell Line, TumorCell MovementCell PolarityHumansRac1 GTP-Binding ProteinRhoA GTP-Binding ProteinRho-Associated Kinases
2016
Rac1 and RhoA: Networks, loops and bistability
Nguyen LK, Kholodenko BN, von Kriegsheim A. Rac1 and RhoA: Networks, loops and bistability. Small GTPases 2016, 9: 316-321. PMID: 27533896, PMCID: PMC5997137, DOI: 10.1080/21541248.2016.1224399.Peer-Reviewed Original Research
2015
Network-based identification of feedback modules that control RhoA activity and cell migration
Kim TH, Monsefi N, Song JH, von Kriegsheim A, Vandamme D, Pertz O, Kholodenko BN, Kolch W, Cho KH. Network-based identification of feedback modules that control RhoA activity and cell migration. Journal Of Molecular Cell Biology 2015, 7: 242-252. PMID: 25780058, DOI: 10.1093/jmcb/mjv017.Peer-Reviewed Original ResearchConceptsRho family GTPasesCancer cell migrationCell migrationRhoA activityControl cell migrationBoolean network modelNetwork-based identificationPotential new targetsRho activationGTPasesSrc inhibitionGenetic backgroundCsk inhibitionMost cancer deathsActivation stateNew targetsNew insightsMigrationCskSrcFAKRewiringInhibitionEGFProtrusion
2013
Control of the G- protein cascade dynamics by GDP dissociation inhibitors
Nikonova E, Tsyganov MA, Kolch W, Fey D, Kholodenko BN. Control of the G- protein cascade dynamics by GDP dissociation inhibitors. Molecular Omics 2013, 9: 2454-2462. PMID: 23872884, DOI: 10.1039/c3mb70152b.Peer-Reviewed Original ResearchConceptsGDP dissociation inhibitorGuanine nucleotide exchange factorsRho family GTPasesDissociation inhibitorNucleotide exchange factorsKey cellular processesProtrusion-retraction cyclesSignal-induced changesCell migration behaviorActive GTPExchange factorInactive GDPCellular processesGTPase activityRac1 activityGTPasesBistable switchRhoADistinct modesRhoGDI1GTPaseInhibitorsRac1GTPCytoplasm