2019
Mapping connections in signaling networks with ambiguous modularity
Lill D, Rukhlenko O, Mc Elwee A, Kashdan E, Timmer J, Kholodenko B. Mapping connections in signaling networks with ambiguous modularity. Npj Systems Biology And Applications 2019, 5: 19. PMID: 31149348, PMCID: PMC6533310, DOI: 10.1038/s41540-019-0096-1.Peer-Reviewed Original ResearchMeSH KeywordsComputational BiologyComputer SimulationGene Regulatory NetworksModels, BiologicalProtein Interaction MapsProteinsSignal TransductionConceptsModular Response AnalysisProtein abundanceProtein complexesNetwork reconstructionDownstream modulesRetroactive interactionsUpstream moduleComputational restorationNetwork modulesSuite of methodsAbundanceSuch complexesExperimental approachComplexesProteinEnzymePathwaySequestration effectNetwork responseDifferent modules
2003
Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law
Peletier M, Westerhoff H, Kholodenko B. Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law. Journal Of Theoretical Biology 2003, 225: 477-487. PMID: 14615206, DOI: 10.1016/s0022-5193(03)00289-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneComputational BiologyDiffusionModels, BiologicalPhosphoric Monoester HydrolasesPhosphotransferasesProteinsSignal TransductionTime FactorsConceptsMetabolic control analysisMembrane transportKinase/phosphatase systemCellular reaction networksIntracellular signaling pathwaysProtein networkIntracellular transportPhosphatase systemSignaling pathwaysControl coefficientsCell sizeSpherical cellsClassical metabolic control analysisActive mechanismProtein
1996
Molecular Control Analysis: Control within Proteins and Molecular Processes
Brown G, Westerhoff H, Kholodenko B. Molecular Control Analysis: Control within Proteins and Molecular Processes. Journal Of Theoretical Biology 1996, 182: 389-396. PMID: 8944172, DOI: 10.1006/jtbi.1996.0178.Peer-Reviewed Original Research